Increased expression of activating transcription factor 3 is related to the biologic behavior of cutaneous squamous cell carcinomas
Summary Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few i...
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| Veröffentlicht in: | Human pathology 2011-07, Vol.42 (7), p.954-959 |
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| container_title | Human pathology |
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| creator | Kim, Myoung Shin In, Seung Gyun Park, Oun Jae Won, Chong Hyun Lee, Mi Woo Choi, Jee Ho Kim, Chan Woong Kim, Sung Eun Moon, Kee Chan Chang, Sungeun |
| description | Summary Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on the possible role of activating transcription factor 3 in skin cancer. In this study, we investigated the expression of activating transcription factor 3 in basal cell carcinomas (n = 5), actinic keratoses (n = 7), squamous cell carcinomas (n = 19), and Bowen disease (n = 14) by immunohistochemistry. In results, activating transcription factor 3 was significantly expressed in squamous cell carcinomas (15/19), suggesting that it is involved in the pathogenesis of squamous cell carcinomas but not in basal cell carcinomas (0/5). In addition, higher expression of activating transcription factor 3 was observed in squamous cell carcinomas that were metastatic ( P < .01) or arose in organ transplant recipients ( P < .05). Therefore, activating transcription factor 3 appears to play an oncogenic role in the development of squamous cell carcinomas and may be related to the biologic behavior of them. |
| doi_str_mv | 10.1016/j.humpath.2010.10.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_873120407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0046817710003886</els_id><sourcerecordid>2743802161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-2cff920f382e3fe5bcf168bd65c49263b208ed8301b00dc682dd7657109469c33</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhJ4AsIcRpl7GdOM4FhCo-KlXiAJwtZzLpeknire2s6Jk_jsMuVOqFk0eeZ8av552ieM5hw4GrN7vNdh73Nm03Av7cbQD0g2LFKynWWjbiYbECKNVa87o-K57EuAPgvCqrx8WZ4DJHAlbFr8sJA9lIHaOf-0AxOj8x3zOLyR1sctM1S8FOEYPbpyXX54wPTDIXWaDBplyaPEtbYq3zg792yFra2oPLVG6Ec7IT-TmyeDPbcQmQhoGhDegmP9r4tHjU2yHSs9N5Xnz_-OHbxef11ZdPlxfvr9ZY1nVaC-z7RkAvtSDZU9Viz5VuO1Vh2QglWwGaOi2BtwAdKi26rlZVzaEpVYNSnhevj333wd_MFJMZXVy0HPUZXUsuoIQ6ky_vkTs_hymLMxxkqRsumiZT1ZHC4GMM1Jt9cKMNtxkyi0lmZ04mmcWk5TqblOtenLrP7Ujdv6q_rmTg1QmwEe3Q5_mji3dcKYVSZZW5d0eO8tQOjoKJ6GhC6lwgTKbz7r9S3t7rgIObXH70B91SvPu1icKA-bps1LJQHACk1kr-Bn9jyM0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034891299</pqid></control><display><type>article</type><title>Increased expression of activating transcription factor 3 is related to the biologic behavior of cutaneous squamous cell carcinomas</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kim, Myoung Shin ; In, Seung Gyun ; Park, Oun Jae ; Won, Chong Hyun ; Lee, Mi Woo ; Choi, Jee Ho ; Kim, Chan Woong ; Kim, Sung Eun ; Moon, Kee Chan ; Chang, Sungeun</creator><creatorcontrib>Kim, Myoung Shin ; In, Seung Gyun ; Park, Oun Jae ; Won, Chong Hyun ; Lee, Mi Woo ; Choi, Jee Ho ; Kim, Chan Woong ; Kim, Sung Eun ; Moon, Kee Chan ; Chang, Sungeun</creatorcontrib><description>Summary Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on the possible role of activating transcription factor 3 in skin cancer. In this study, we investigated the expression of activating transcription factor 3 in basal cell carcinomas (n = 5), actinic keratoses (n = 7), squamous cell carcinomas (n = 19), and Bowen disease (n = 14) by immunohistochemistry. In results, activating transcription factor 3 was significantly expressed in squamous cell carcinomas (15/19), suggesting that it is involved in the pathogenesis of squamous cell carcinomas but not in basal cell carcinomas (0/5). In addition, higher expression of activating transcription factor 3 was observed in squamous cell carcinomas that were metastatic ( P < .01) or arose in organ transplant recipients ( P < .05). Therefore, activating transcription factor 3 appears to play an oncogenic role in the development of squamous cell carcinomas and may be related to the biologic behavior of them.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2010.10.008</identifier><identifier>PMID: 21315420</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Activating transcription factor 3 ; Activating Transcription Factor 3 - metabolism ; Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Biological and medical sciences ; Bowen's Disease - metabolism ; Breast cancer ; Carcinoma, Basal Cell - metabolism ; Carcinoma, Squamous Cell - metabolism ; Cell adhesion & migration ; Deoxyribonucleic acid ; Dermatology ; DNA ; DNA damage ; Female ; Humans ; Immunohistochemistry ; Infections ; Investigative techniques, diagnostic techniques (general aspects) ; Lymphoma ; Male ; Medical sciences ; Middle Aged ; Mortality ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Skin ; Skin neoplasms ; Skin Neoplasms - metabolism ; Squamous cell carcinoma ; Studies ; Transplants & implants ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Human pathology, 2011-07, Vol.42 (7), p.954-959</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-2cff920f382e3fe5bcf168bd65c49263b208ed8301b00dc682dd7657109469c33</citedby><cites>FETCH-LOGICAL-c477t-2cff920f382e3fe5bcf168bd65c49263b208ed8301b00dc682dd7657109469c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817710003886$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24326645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21315420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Myoung Shin</creatorcontrib><creatorcontrib>In, Seung Gyun</creatorcontrib><creatorcontrib>Park, Oun Jae</creatorcontrib><creatorcontrib>Won, Chong Hyun</creatorcontrib><creatorcontrib>Lee, Mi Woo</creatorcontrib><creatorcontrib>Choi, Jee Ho</creatorcontrib><creatorcontrib>Kim, Chan Woong</creatorcontrib><creatorcontrib>Kim, Sung Eun</creatorcontrib><creatorcontrib>Moon, Kee Chan</creatorcontrib><creatorcontrib>Chang, Sungeun</creatorcontrib><title>Increased expression of activating transcription factor 3 is related to the biologic behavior of cutaneous squamous cell carcinomas</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on the possible role of activating transcription factor 3 in skin cancer. In this study, we investigated the expression of activating transcription factor 3 in basal cell carcinomas (n = 5), actinic keratoses (n = 7), squamous cell carcinomas (n = 19), and Bowen disease (n = 14) by immunohistochemistry. In results, activating transcription factor 3 was significantly expressed in squamous cell carcinomas (15/19), suggesting that it is involved in the pathogenesis of squamous cell carcinomas but not in basal cell carcinomas (0/5). In addition, higher expression of activating transcription factor 3 was observed in squamous cell carcinomas that were metastatic ( P < .01) or arose in organ transplant recipients ( P < .05). Therefore, activating transcription factor 3 appears to play an oncogenic role in the development of squamous cell carcinomas and may be related to the biologic behavior of them.</description><subject>Activating transcription factor 3</subject><subject>Activating Transcription Factor 3 - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Bowen's Disease - metabolism</subject><subject>Breast cancer</subject><subject>Carcinoma, Basal Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Cell adhesion & migration</subject><subject>Deoxyribonucleic acid</subject><subject>Dermatology</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infections</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Skin</subject><subject>Skin neoplasms</subject><subject>Skin Neoplasms - metabolism</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>Transplants & implants</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhJ4AsIcRpl7GdOM4FhCo-KlXiAJwtZzLpeknire2s6Jk_jsMuVOqFk0eeZ8av552ieM5hw4GrN7vNdh73Nm03Av7cbQD0g2LFKynWWjbiYbECKNVa87o-K57EuAPgvCqrx8WZ4DJHAlbFr8sJA9lIHaOf-0AxOj8x3zOLyR1sctM1S8FOEYPbpyXX54wPTDIXWaDBplyaPEtbYq3zg792yFra2oPLVG6Ec7IT-TmyeDPbcQmQhoGhDegmP9r4tHjU2yHSs9N5Xnz_-OHbxef11ZdPlxfvr9ZY1nVaC-z7RkAvtSDZU9Viz5VuO1Vh2QglWwGaOi2BtwAdKi26rlZVzaEpVYNSnhevj333wd_MFJMZXVy0HPUZXUsuoIQ6ky_vkTs_hymLMxxkqRsumiZT1ZHC4GMM1Jt9cKMNtxkyi0lmZ04mmcWk5TqblOtenLrP7Ujdv6q_rmTg1QmwEe3Q5_mji3dcKYVSZZW5d0eO8tQOjoKJ6GhC6lwgTKbz7r9S3t7rgIObXH70B91SvPu1icKA-bps1LJQHACk1kr-Bn9jyM0</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Kim, Myoung Shin</creator><creator>In, Seung Gyun</creator><creator>Park, Oun Jae</creator><creator>Won, Chong Hyun</creator><creator>Lee, Mi Woo</creator><creator>Choi, Jee Ho</creator><creator>Kim, Chan Woong</creator><creator>Kim, Sung Eun</creator><creator>Moon, Kee Chan</creator><creator>Chang, Sungeun</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Increased expression of activating transcription factor 3 is related to the biologic behavior of cutaneous squamous cell carcinomas</title><author>Kim, Myoung Shin ; In, Seung Gyun ; Park, Oun Jae ; Won, Chong Hyun ; Lee, Mi Woo ; Choi, Jee Ho ; Kim, Chan Woong ; Kim, Sung Eun ; Moon, Kee Chan ; Chang, Sungeun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-2cff920f382e3fe5bcf168bd65c49263b208ed8301b00dc682dd7657109469c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Activating transcription factor 3</topic><topic>Activating Transcription Factor 3 - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Bowen's Disease - metabolism</topic><topic>Breast cancer</topic><topic>Carcinoma, Basal Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Cell adhesion & migration</topic><topic>Deoxyribonucleic acid</topic><topic>Dermatology</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infections</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Skin</topic><topic>Skin neoplasms</topic><topic>Skin Neoplasms - metabolism</topic><topic>Squamous cell carcinoma</topic><topic>Studies</topic><topic>Transplants & implants</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Myoung Shin</creatorcontrib><creatorcontrib>In, Seung Gyun</creatorcontrib><creatorcontrib>Park, Oun Jae</creatorcontrib><creatorcontrib>Won, Chong Hyun</creatorcontrib><creatorcontrib>Lee, Mi Woo</creatorcontrib><creatorcontrib>Choi, Jee Ho</creatorcontrib><creatorcontrib>Kim, Chan Woong</creatorcontrib><creatorcontrib>Kim, Sung Eun</creatorcontrib><creatorcontrib>Moon, Kee Chan</creatorcontrib><creatorcontrib>Chang, Sungeun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Myoung Shin</au><au>In, Seung Gyun</au><au>Park, Oun Jae</au><au>Won, Chong Hyun</au><au>Lee, Mi Woo</au><au>Choi, Jee Ho</au><au>Kim, Chan Woong</au><au>Kim, Sung Eun</au><au>Moon, Kee Chan</au><au>Chang, Sungeun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of activating transcription factor 3 is related to the biologic behavior of cutaneous squamous cell carcinomas</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>42</volume><issue>7</issue><spage>954</spage><epage>959</epage><pages>954-959</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Activating transcription factor 3, a member of the activating transcription factor/cyclic adenosine monophosphate response element-binding family of transcription factors, is an adaptive response gene that plays an oncogenic role in the development of various cancers. To our knowledge, few information are available on the possible role of activating transcription factor 3 in skin cancer. In this study, we investigated the expression of activating transcription factor 3 in basal cell carcinomas (n = 5), actinic keratoses (n = 7), squamous cell carcinomas (n = 19), and Bowen disease (n = 14) by immunohistochemistry. In results, activating transcription factor 3 was significantly expressed in squamous cell carcinomas (15/19), suggesting that it is involved in the pathogenesis of squamous cell carcinomas but not in basal cell carcinomas (0/5). In addition, higher expression of activating transcription factor 3 was observed in squamous cell carcinomas that were metastatic ( P < .01) or arose in organ transplant recipients ( P < .05). Therefore, activating transcription factor 3 appears to play an oncogenic role in the development of squamous cell carcinomas and may be related to the biologic behavior of them.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21315420</pmid><doi>10.1016/j.humpath.2010.10.008</doi><tpages>6</tpages></addata></record> |
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| subjects | Activating transcription factor 3 Activating Transcription Factor 3 - metabolism Adult Aged Aged, 80 and over Apoptosis Biological and medical sciences Bowen's Disease - metabolism Breast cancer Carcinoma, Basal Cell - metabolism Carcinoma, Squamous Cell - metabolism Cell adhesion & migration Deoxyribonucleic acid Dermatology DNA DNA damage Female Humans Immunohistochemistry Infections Investigative techniques, diagnostic techniques (general aspects) Lymphoma Male Medical sciences Middle Aged Mortality Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Skin Skin neoplasms Skin Neoplasms - metabolism Squamous cell carcinoma Studies Transplants & implants Tumors of the skin and soft tissue. Premalignant lesions |
| title | Increased expression of activating transcription factor 3 is related to the biologic behavior of cutaneous squamous cell carcinomas |
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