Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase

PGC-1α is a transcriptional coactivator that powerfully regulates many pathways linked to energy homeostasis. Specifically, PGC-1α controls mitochondrial biogenesis in most tissues but also initiates important tissue-specific functions, including fiber type switching in skeletal muscle and gluconeog...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Genes & development 2011-06, Vol.25 (12), p.1232-1244
Hauptverfasser:	Lustig, Yaniv, Ruas, Jorge L, Estall, Jennifer L, Lo, James C, Devarakonda, Srikripa, Laznik, Dina, Choi, Jang Hyun, Ono, Hiraku, Olsen, Jesper V, Spiegelman, Bruce M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Gluconeogenesis - physiology HEK293 Cells Humans Mice Mice, Inbred BALB C Mitochondria - metabolism Ribosomal Protein S6 Kinases - metabolism Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!