Overexpression of LAPTM4B-35 attenuates epirubucin-induced apoptosis of gallbladder carcinoma GBC-SD cells

Background It was shown previously that LAPTM4B promoted growth of gallbladder carcinoma (GBC) cells and predicted poor prognosis in GBC; however, its roles and relative mechanisms in apoptosis of GBC cells remain unknown. Methods The plasmids, pcDNA3-AE, containing the complete open reading frame o...

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Veröffentlicht in:	Surgery 2011-07, Vol.150 (1), p.25-31
Hauptverfasser:	Zhou, Li, MD, He, Xiao-Dong, MD, Yu, Jian-Chun, MD, Zhou, Rou-Li, MD, Shan, Yi, MD, Rui, Jing-An, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Apoptosis - drug effects Apoptosis - genetics bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism BH3 Interacting Domain Death Agonist Protein - metabolism Biological and medical sciences Caspase 3 - metabolism Caspase 9 - metabolism Cell Line, Tumor Drug Resistance, Neoplasm - genetics Epirubicin - pharmacology Gallbladder Neoplasms - drug therapy Gallbladder Neoplasms - genetics Gallbladder Neoplasms - metabolism Gallbladder Neoplasms - pathology Gene Expression General aspects Humans Medical sciences Membrane Proteins - genetics Mitochondria - drug effects Mitochondria - metabolism Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Surgery Transfection
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