Association between gestational age and induction-to-abortion interval in mid-trimester pregnancy termination using misoprostol
Abstract Objective The study was aimed to evaluate the effectiveness, outcome, and pain intensity of the vaginal administration of misoprostol for the induction of abortion between 13 and 24 gestational weeks. Study design A retrospective study was conducted at our tertiary medical center from Janua...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2011-06, Vol.156 (2), p.140-143 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Vitner, Dana Deutsch, Michael Paz, Yuri Khatib, Nizar Baltiter, Tania Rosenberg, Shiran Lowenstein, Lior |
| description | Abstract Objective The study was aimed to evaluate the effectiveness, outcome, and pain intensity of the vaginal administration of misoprostol for the induction of abortion between 13 and 24 gestational weeks. Study design A retrospective study was conducted at our tertiary medical center from January 2006 to December 2009 on 122 consecutive women who underwent termination of pregnancy (TOP) in the mid-trimester. They were given 400 mcg of vaginal misoprostol every 6 h, up to four doses. The induction-to-abortion interval and the level of pain experienced during the process were assessed. Success was defined by the fetus being expelled within 48 h. Results Vaginal misoprostol was effective in 84% (98/122) of patients. The median duration of the induction-to-abortion interval was 16 (5–48) h. The induction-to-abortion interval was correlated with gestational age, while inversely correlated with parity. A correlation was also found between gestational age and pain intensity at 12 h from induction. Conclusion Misoprostol is safe and effective in mid-trimester abortion induction. The induction-to-abortion interval is shorter and abortion less painful with lower gestational age. Higher parity is also associated with shorter induction to abortion interval. |
| doi_str_mv | 10.1016/j.ejogrb.2010.12.035 |
| format | Article |
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Study design A retrospective study was conducted at our tertiary medical center from January 2006 to December 2009 on 122 consecutive women who underwent termination of pregnancy (TOP) in the mid-trimester. They were given 400 mcg of vaginal misoprostol every 6 h, up to four doses. The induction-to-abortion interval and the level of pain experienced during the process were assessed. Success was defined by the fetus being expelled within 48 h. Results Vaginal misoprostol was effective in 84% (98/122) of patients. The median duration of the induction-to-abortion interval was 16 (5–48) h. The induction-to-abortion interval was correlated with gestational age, while inversely correlated with parity. A correlation was also found between gestational age and pain intensity at 12 h from induction. Conclusion Misoprostol is safe and effective in mid-trimester abortion induction. The induction-to-abortion interval is shorter and abortion less painful with lower gestational age. Higher parity is also associated with shorter induction to abortion interval.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2010.12.035</identifier><identifier>PMID: 21507550</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Abortifacient Agents, Nonsteroidal - administration & dosage ; Abortion, Induced - adverse effects ; Abortion, Induced - methods ; Administration, Intravaginal ; Adult ; Biological and medical sciences ; Birth control ; Digestive system ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Induced abortion. Therapeutic abortion ; Medical sciences ; Mid-trimester abortion ; Misoprostol ; Misoprostol - administration & dosage ; Obstetrics and Gynecology ; Pain - etiology ; Pain Measurement ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Trimester, Second ; Retrospective Studies ; Termination of pregnancy (TOP) ; Treatment Outcome ; Young Adult</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2011-06, Vol.156 (2), p.140-143</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-fd79a9fb2cde1eb56f576a6d266814267449f2c3d2c72f9e1c584f378dac967b3</citedby><cites>FETCH-LOGICAL-c512t-fd79a9fb2cde1eb56f576a6d266814267449f2c3d2c72f9e1c584f378dac967b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejogrb.2010.12.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24302970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21507550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vitner, Dana</creatorcontrib><creatorcontrib>Deutsch, Michael</creatorcontrib><creatorcontrib>Paz, Yuri</creatorcontrib><creatorcontrib>Khatib, Nizar</creatorcontrib><creatorcontrib>Baltiter, Tania</creatorcontrib><creatorcontrib>Rosenberg, Shiran</creatorcontrib><creatorcontrib>Lowenstein, Lior</creatorcontrib><title>Association between gestational age and induction-to-abortion interval in mid-trimester pregnancy termination using misoprostol</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objective The study was aimed to evaluate the effectiveness, outcome, and pain intensity of the vaginal administration of misoprostol for the induction of abortion between 13 and 24 gestational weeks. Study design A retrospective study was conducted at our tertiary medical center from January 2006 to December 2009 on 122 consecutive women who underwent termination of pregnancy (TOP) in the mid-trimester. They were given 400 mcg of vaginal misoprostol every 6 h, up to four doses. The induction-to-abortion interval and the level of pain experienced during the process were assessed. Success was defined by the fetus being expelled within 48 h. Results Vaginal misoprostol was effective in 84% (98/122) of patients. The median duration of the induction-to-abortion interval was 16 (5–48) h. The induction-to-abortion interval was correlated with gestational age, while inversely correlated with parity. A correlation was also found between gestational age and pain intensity at 12 h from induction. Conclusion Misoprostol is safe and effective in mid-trimester abortion induction. The induction-to-abortion interval is shorter and abortion less painful with lower gestational age. Higher parity is also associated with shorter induction to abortion interval.</description><subject>Abortifacient Agents, Nonsteroidal - administration & dosage</subject><subject>Abortion, Induced - adverse effects</subject><subject>Abortion, Induced - methods</subject><subject>Administration, Intravaginal</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Induced abortion. Therapeutic abortion</subject><subject>Medical sciences</subject><subject>Mid-trimester abortion</subject><subject>Misoprostol</subject><subject>Misoprostol - administration & dosage</subject><subject>Obstetrics and Gynecology</subject><subject>Pain - etiology</subject><subject>Pain Measurement</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Retrospective Studies</subject><subject>Termination of pregnancy (TOP)</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkGP1SAUhYnROM_Rf2BMN2ZWfQIt0G5MJhNHTSZxoa4JhduG2gdPaMe8lX_d2-lTEzeyIdx8h3M5XEJeMrpnlMk34x7GOKRuz-la4ntaiUdkxxrFSyVF_ZjsaEVZyRkTF-RZziPFVVXtU3LBmaBKCLojP69zjtab2cdQdDD_AAjFAHl-qJipMAMUJrjCB7fYtVbOsTRdTA8KH2ZI94j5UBy8K-fkDyiGVBwTDMEEeyrwdPBhc1iyDwOSOR5TzHOcnpMnvZkyvDjvl-Tr7bsvNx_Ku0_vP95c35VWMD6XvVOtafuOWwcMOiF7oaSRjkvZsJpLVddtz23luFW8b4FZ0dR9pRpnbCtVV12Sq-1e9P2-YIsam7AwTSZAXLLG1ARXVdMgWW-kxQ5zgl4f8VEmnTSjek1ej3pLXq_Ja8Y1Jo-yV2eDpTuA-yP6HTUCr8-AydZMfcJwfP7L1RXlrVq5txsHGMe9h6Sz9RAsOJ_AztpF_79O_r3ATj549PwGJ8hjXBJ-bNZMZxToz-uUrEPCGM4Hk231CznGu8E</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Vitner, Dana</creator><creator>Deutsch, Michael</creator><creator>Paz, Yuri</creator><creator>Khatib, Nizar</creator><creator>Baltiter, Tania</creator><creator>Rosenberg, Shiran</creator><creator>Lowenstein, Lior</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Association between gestational age and induction-to-abortion interval in mid-trimester pregnancy termination using misoprostol</title><author>Vitner, Dana ; Deutsch, Michael ; Paz, Yuri ; Khatib, Nizar ; Baltiter, Tania ; Rosenberg, Shiran ; Lowenstein, Lior</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-fd79a9fb2cde1eb56f576a6d266814267449f2c3d2c72f9e1c584f378dac967b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abortifacient Agents, Nonsteroidal - administration & dosage</topic><topic>Abortion, Induced - adverse effects</topic><topic>Abortion, Induced - methods</topic><topic>Administration, Intravaginal</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Induced abortion. Therapeutic abortion</topic><topic>Medical sciences</topic><topic>Mid-trimester abortion</topic><topic>Misoprostol</topic><topic>Misoprostol - administration & dosage</topic><topic>Obstetrics and Gynecology</topic><topic>Pain - etiology</topic><topic>Pain Measurement</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Retrospective Studies</topic><topic>Termination of pregnancy (TOP)</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vitner, Dana</creatorcontrib><creatorcontrib>Deutsch, Michael</creatorcontrib><creatorcontrib>Paz, Yuri</creatorcontrib><creatorcontrib>Khatib, Nizar</creatorcontrib><creatorcontrib>Baltiter, Tania</creatorcontrib><creatorcontrib>Rosenberg, Shiran</creatorcontrib><creatorcontrib>Lowenstein, Lior</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vitner, Dana</au><au>Deutsch, Michael</au><au>Paz, Yuri</au><au>Khatib, Nizar</au><au>Baltiter, Tania</au><au>Rosenberg, Shiran</au><au>Lowenstein, Lior</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between gestational age and induction-to-abortion interval in mid-trimester pregnancy termination using misoprostol</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>156</volume><issue>2</issue><spage>140</spage><epage>143</epage><pages>140-143</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Abstract Objective The study was aimed to evaluate the effectiveness, outcome, and pain intensity of the vaginal administration of misoprostol for the induction of abortion between 13 and 24 gestational weeks. Study design A retrospective study was conducted at our tertiary medical center from January 2006 to December 2009 on 122 consecutive women who underwent termination of pregnancy (TOP) in the mid-trimester. They were given 400 mcg of vaginal misoprostol every 6 h, up to four doses. The induction-to-abortion interval and the level of pain experienced during the process were assessed. Success was defined by the fetus being expelled within 48 h. Results Vaginal misoprostol was effective in 84% (98/122) of patients. The median duration of the induction-to-abortion interval was 16 (5–48) h. The induction-to-abortion interval was correlated with gestational age, while inversely correlated with parity. A correlation was also found between gestational age and pain intensity at 12 h from induction. Conclusion Misoprostol is safe and effective in mid-trimester abortion induction. The induction-to-abortion interval is shorter and abortion less painful with lower gestational age. Higher parity is also associated with shorter induction to abortion interval.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21507550</pmid><doi>10.1016/j.ejogrb.2010.12.035</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2011-06, Vol.156 (2), p.140-143 |
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| subjects | Abortifacient Agents, Nonsteroidal - administration & dosage Abortion, Induced - adverse effects Abortion, Induced - methods Administration, Intravaginal Adult Biological and medical sciences Birth control Digestive system Female Gestational Age Gynecology. Andrology. Obstetrics Humans Induced abortion. Therapeutic abortion Medical sciences Mid-trimester abortion Misoprostol Misoprostol - administration & dosage Obstetrics and Gynecology Pain - etiology Pain Measurement Pharmacology. Drug treatments Pregnancy Pregnancy Trimester, Second Retrospective Studies Termination of pregnancy (TOP) Treatment Outcome Young Adult |
| title | Association between gestational age and induction-to-abortion interval in mid-trimester pregnancy termination using misoprostol |
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