α1-Adrenoreceptor activity does not explain lower morning endothelial-dependent, flow-mediated dilation in humans

Early morning reduction in endothelium-dependent, flow-mediated dilation (FMD) may contribute to the high incidence of sudden cardiac death at this time of day. The mechanisms underpinning diurnal variation in FMD are unclear, but potentially relate to a circadian rhythm in sympathetic nerve activit...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2011-06, Vol.300 (6), p.R1437-R1442
Hauptverfasser:	Jones, Helen, Lewis, Nia C S, Green, Daniel J, Ainslie, Philip N, Lucas, Samuel J E, Tzeng, Yu-Chieh, Grant, Emily J M, Atkinson, Greg
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Antagonists - pharmacology Adult Blood Pressure - physiology Brachial Artery - drug effects Brachial Artery - physiology Circadian Rhythm - physiology Death, Sudden, Cardiac - epidemiology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Female Heart Rate - physiology Humans Incidence Male Prazosin - pharmacology Receptors, Adrenergic, alpha-1 - drug effects Receptors, Adrenergic, alpha-1 - physiology Regional Blood Flow - drug effects Regional Blood Flow - physiology Sympathetic Nervous System - physiology Vasodilation - drug effects Vasodilation - physiology
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