Radiotherapy for extramammary Paget disease of the anogenital region
Extramammary Paget disease is a rare condition that most commonly affects the anogenital region in the elderly. The treatment of choice has been surgical excision of the affected area with adequate depth and lateral margins, criteria that cannot always be fulfilled, especially when the vulva, anal c...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2011-07, Vol.65 (1), p.192-194 |
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| creator | Dilmé-Carreras, Elisabet, MD Iglesias-Sancho, Maribel, MD Márquez-Balbás, Gemma, MD Sola-Ortigosa, Joaquín, MD Umbert-Millet, Pablo, MD |
| description | Extramammary Paget disease is a rare condition that most commonly affects the anogenital region in the elderly. The treatment of choice has been surgical excision of the affected area with adequate depth and lateral margins, criteria that cannot always be fulfilled, especially when the vulva, anal canal, or penis are involved. More recently radiotherapy has been suggested as a suitable treatment when surgical excision or other modalities are not appropriate. We report a case of anogenital extramammary Paget disease and the clinical response to treatment with radiotherapy. The aim of this article is to review relevant aspects of radiotherapy as a first-choice curative treatment in specific situations of anogenital extramammary Paget disease in situ. |
| doi_str_mv | 10.1016/j.jaad.2009.11.689 |
| format | Article |
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The treatment of choice has been surgical excision of the affected area with adequate depth and lateral margins, criteria that cannot always be fulfilled, especially when the vulva, anal canal, or penis are involved. More recently radiotherapy has been suggested as a suitable treatment when surgical excision or other modalities are not appropriate. We report a case of anogenital extramammary Paget disease and the clinical response to treatment with radiotherapy. The aim of this article is to review relevant aspects of radiotherapy as a first-choice curative treatment in specific situations of anogenital extramammary Paget disease in situ.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2009.11.689</identifier><identifier>PMID: 20655128</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Aged ; Biological and medical sciences ; Biopsy, Needle ; Dermatology ; Diseases of the osteoarticular system ; extramammary Paget disease ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Medical sciences ; Neoplasm Staging ; Osteoporosis. Osteomalacia. Paget disease ; Paget Disease, Extramammary - diagnosis ; Paget Disease, Extramammary - pathology ; Paget Disease, Extramammary - radiotherapy ; Perineum - pathology ; radiotherapy ; Radiotherapy Dosage ; Rare Diseases ; Risk Assessment ; Skin Neoplasms - diagnosis ; Skin Neoplasms - pathology ; Skin Neoplasms - radiotherapy ; topical 5-fluorouracil ; Treatment Outcome ; Vulva - pathology</subject><ispartof>Journal of the American Academy of Dermatology, 2011-07, Vol.65 (1), p.192-194</ispartof><rights>American Academy of Dermatology, Inc.</rights><rights>2009 American Academy of Dermatology, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-a2c4bb14aa9d003edc9e6c67f57f5a730ab166b95ca2256c59c78369931b8ad63</citedby><cites>FETCH-LOGICAL-c440t-a2c4bb14aa9d003edc9e6c67f57f5a730ab166b95ca2256c59c78369931b8ad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaad.2009.11.689$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24297760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20655128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dilmé-Carreras, Elisabet, MD</creatorcontrib><creatorcontrib>Iglesias-Sancho, Maribel, MD</creatorcontrib><creatorcontrib>Márquez-Balbás, Gemma, MD</creatorcontrib><creatorcontrib>Sola-Ortigosa, Joaquín, MD</creatorcontrib><creatorcontrib>Umbert-Millet, Pablo, MD</creatorcontrib><title>Radiotherapy for extramammary Paget disease of the anogenital region</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Extramammary Paget disease is a rare condition that most commonly affects the anogenital region in the elderly. The treatment of choice has been surgical excision of the affected area with adequate depth and lateral margins, criteria that cannot always be fulfilled, especially when the vulva, anal canal, or penis are involved. More recently radiotherapy has been suggested as a suitable treatment when surgical excision or other modalities are not appropriate. We report a case of anogenital extramammary Paget disease and the clinical response to treatment with radiotherapy. The aim of this article is to review relevant aspects of radiotherapy as a first-choice curative treatment in specific situations of anogenital extramammary Paget disease in situ.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Dermatology</subject><subject>Diseases of the osteoarticular system</subject><subject>extramammary Paget disease</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Neoplasm Staging</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Paget Disease, Extramammary - diagnosis</subject><subject>Paget Disease, Extramammary - pathology</subject><subject>Paget Disease, Extramammary - radiotherapy</subject><subject>Perineum - pathology</subject><subject>radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Rare Diseases</subject><subject>Risk Assessment</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - radiotherapy</subject><subject>topical 5-fluorouracil</subject><subject>Treatment Outcome</subject><subject>Vulva - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1TAQhoMo7nH1D3ghvRGv2p2kbdKACLJ-LSwofoB3YZpOj6ltczbpEc-_N-UcFfZiYSA3zzszeYaxpxwKDlxeDMWA2BUCQBecF7LR99iGg1a5VI26zzbANeRaCnHGHsU4QAKrUj1kZwJkXXPRbNibz9g5v_yggLtD1vuQ0e8l4ITThOGQfcItLVnnImGkzPdZIjOc_ZZmt-CYBdo6Pz9mD3ocIz05vefs27u3Xy8_5Ncf319dvr7ObVXBkqOwVdvyClF3ACV1VpO0UvV1KlQlYMulbHVtUYha2lpb1ZRS65K3DXayPGcvjn13wd_sKS5mctHSOOJMfh9No0RVcQCRSHEkbfAxBurNLrj1R4aDWeWZwazyzCrPcG6SvBR6dmq_byfq_kX-2krA8xOA0eLYB5yti_-5SmilJCTu5ZGjJOOXo2CidTRb6lwgu5jOu7v3eHUrbkc3uzTxJx0oDn4f5qTZcBOFAfNlPfN6ZdAg0gbfyz8pjKHm</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Dilmé-Carreras, Elisabet, MD</creator><creator>Iglesias-Sancho, Maribel, MD</creator><creator>Márquez-Balbás, Gemma, MD</creator><creator>Sola-Ortigosa, Joaquín, MD</creator><creator>Umbert-Millet, Pablo, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Radiotherapy for extramammary Paget disease of the anogenital region</title><author>Dilmé-Carreras, Elisabet, MD ; Iglesias-Sancho, Maribel, MD ; Márquez-Balbás, Gemma, MD ; Sola-Ortigosa, Joaquín, MD ; Umbert-Millet, Pablo, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-a2c4bb14aa9d003edc9e6c67f57f5a730ab166b95ca2256c59c78369931b8ad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Dermatology</topic><topic>Diseases of the osteoarticular system</topic><topic>extramammary Paget disease</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Neoplasm Staging</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Paget Disease, Extramammary - diagnosis</topic><topic>Paget Disease, Extramammary - pathology</topic><topic>Paget Disease, Extramammary - radiotherapy</topic><topic>Perineum - pathology</topic><topic>radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Rare Diseases</topic><topic>Risk Assessment</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - radiotherapy</topic><topic>topical 5-fluorouracil</topic><topic>Treatment Outcome</topic><topic>Vulva - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dilmé-Carreras, Elisabet, MD</creatorcontrib><creatorcontrib>Iglesias-Sancho, Maribel, MD</creatorcontrib><creatorcontrib>Márquez-Balbás, Gemma, MD</creatorcontrib><creatorcontrib>Sola-Ortigosa, Joaquín, MD</creatorcontrib><creatorcontrib>Umbert-Millet, Pablo, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dilmé-Carreras, Elisabet, MD</au><au>Iglesias-Sancho, Maribel, MD</au><au>Márquez-Balbás, Gemma, MD</au><au>Sola-Ortigosa, Joaquín, MD</au><au>Umbert-Millet, Pablo, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiotherapy for extramammary Paget disease of the anogenital region</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>65</volume><issue>1</issue><spage>192</spage><epage>194</epage><pages>192-194</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Extramammary Paget disease is a rare condition that most commonly affects the anogenital region in the elderly. 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| subjects | Aged Biological and medical sciences Biopsy, Needle Dermatology Diseases of the osteoarticular system extramammary Paget disease Female Follow-Up Studies Humans Immunohistochemistry Medical sciences Neoplasm Staging Osteoporosis. Osteomalacia. Paget disease Paget Disease, Extramammary - diagnosis Paget Disease, Extramammary - pathology Paget Disease, Extramammary - radiotherapy Perineum - pathology radiotherapy Radiotherapy Dosage Rare Diseases Risk Assessment Skin Neoplasms - diagnosis Skin Neoplasms - pathology Skin Neoplasms - radiotherapy topical 5-fluorouracil Treatment Outcome Vulva - pathology |
| title | Radiotherapy for extramammary Paget disease of the anogenital region |
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