Adipose Tissue-Derived Soluble Fms-Like Tyrosine Kinase 1 Is an Obesity-Relevant Endogenous Paracrine Adipokine

Adipose tissue growth depends on angiogenesis. We tested the hypothesis that adipose tissue produces factors relevant to angiogenesis. We obtained fat biopsies in 2 different patient cohorts, cultured adipose-derived stem cells and studied mature adipocytes. We performed microarray, RT-PCR, and West...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2011-07, Vol.58 (1), p.37-42
Hauptverfasser:	Herse, Florian, Fain, John N, Janke, Juergen, Engeli, Stefan, Kuhn, Christian, Frey, Norbert, Weich, Herbert A, Bergmann, Astrid, Kappert, Kai, Karumanchi, S Ananth, Luft, Friedrich C, Muller, Dominik N, Staff, Anne C, Dechend, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adipocytes - pathology Adipokines - metabolism Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blotting, Western Body Mass Index Cardiology. Vascular system Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Gene Expression Regulation Humans Immunohistochemistry Male Medical sciences Metabolic diseases Mice Mice, Obese Neovascularization, Pathologic - etiology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Obesity Obesity - enzymology Obesity - genetics Obesity - pathology Rats Rats, Transgenic Reverse Transcriptase Polymerase Chain Reaction RNA - genetics Vascular Endothelial Growth Factor Receptor-1 - biosynthesis Vascular Endothelial Growth Factor Receptor-1 - genetics
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