Glaucomatous eye macular ganglion cell complex thickness and its relation to temporal circumpapillary retinal nerve fiber layer thickness
Purpose To clarify the correlation between temporal circumpapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness in glaucomatous eyes. Methods Seventy-seven eyes of 77 subjects were categorized as normal, early glaucoma and moderate-to-advanced (moder...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2011-05, Vol.55 (3), p.228-234 |
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| creator | Kita, Yoshiyuki Kita, Ritsuko Nitta, Ai Nishimura, Chiaki Tomita, Goji |
| description | Purpose
To clarify the correlation between temporal circumpapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness in glaucomatous eyes.
Methods
Seventy-seven eyes of 77 subjects were categorized as normal, early glaucoma and moderate-to-advanced (moderate) glaucoma. After the circumpapillary RNFL thickness and mGCC thickness were measured, the temporal mean RNFL and mean mGCC were compared within the three groups. The study also investigated whether there was any correlation between the temporal RNFL and mGCC thicknesses.
Results
In the glaucoma groups, significant thinning of the temporal RNFL and mGCC thicknesses was noted. With the exception of the papillomacular bundle (
r
= −0.078), correlations were seen in each of the early glaucoma mGCC and temporal RNFL sectors (
r
= 0.38–0.753). Correlations were also noted for the mGCC and all temporal RNFL sectors in the moderate glaucoma group (
r
= 0.425–0.809).
Conclusions
From the early stage of glaucoma, similar decreases of the mGCC and RNFL occured, and a high correlation existed between the two. Therefore, like RNFL, mGCC can potentially be used to detect the early stages of glaucoma. However, in early glaucoma eyes, the papillomacular bundle of the RNFL may be spared, even though mGCC thinning is present. |
| doi_str_mv | 10.1007/s10384-011-0017-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_872440359</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2377248521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-2d13aa3d4625f06eef3d66f2dae4e1c09b8f950f2d6e1f3b9d6d0fbde0f410c13</originalsourceid><addsrcrecordid>eNp9kc9u1DAQhy0EosvCA3BBFhd6CczYjpMcUQUFqRIXOEeOPV5SnD_YScU-Am-N0y1FQoKLLXm--ayZH2PPEV4jQPUmIchaFYBYAGBVyAdshxplIYTSD9kOQGBRYlmesScpXQOAElI8ZmcCS1nn6o79vAxmtdNglmlNnI7EB2PXYCI_mPEQ-mnklkLgGZkD_eDL195-GyklbkbH-yXxSMEsG7dMfKFhnqLJeB_tOsxm7kN2HTO09GN-HyneEPd9R5EHc8znvfApe-RNSPTs7t6zL-_ffb74UFx9uvx48faqsEpUSyEcSmOkU1qUHjSRl05rL5whRWih6WrflJAfNKGXXeO0A985Aq8QLMo9e3XyznH6vlJa2qFP24xmpLyDtq6EUiDLJpPn_yURRA1VLcQmffkXej2tMU9868Om0Xnje4YnyMYppUi-nWM_5PVkU7sF2p4CbXOg7RZoK3PPizvx2g3k7jt-J5gBcQJSLo0Hin9-_rf1F-r8rjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>872199615</pqid></control><display><type>article</type><title>Glaucomatous eye macular ganglion cell complex thickness and its relation to temporal circumpapillary retinal nerve fiber layer thickness</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Kita, Yoshiyuki ; Kita, Ritsuko ; Nitta, Ai ; Nishimura, Chiaki ; Tomita, Goji</creator><creatorcontrib>Kita, Yoshiyuki ; Kita, Ritsuko ; Nitta, Ai ; Nishimura, Chiaki ; Tomita, Goji</creatorcontrib><description>Purpose
To clarify the correlation between temporal circumpapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness in glaucomatous eyes.
Methods
Seventy-seven eyes of 77 subjects were categorized as normal, early glaucoma and moderate-to-advanced (moderate) glaucoma. After the circumpapillary RNFL thickness and mGCC thickness were measured, the temporal mean RNFL and mean mGCC were compared within the three groups. The study also investigated whether there was any correlation between the temporal RNFL and mGCC thicknesses.
Results
In the glaucoma groups, significant thinning of the temporal RNFL and mGCC thicknesses was noted. With the exception of the papillomacular bundle (
r
= −0.078), correlations were seen in each of the early glaucoma mGCC and temporal RNFL sectors (
r
= 0.38–0.753). Correlations were also noted for the mGCC and all temporal RNFL sectors in the moderate glaucoma group (
r
= 0.425–0.809).
Conclusions
From the early stage of glaucoma, similar decreases of the mGCC and RNFL occured, and a high correlation existed between the two. Therefore, like RNFL, mGCC can potentially be used to detect the early stages of glaucoma. However, in early glaucoma eyes, the papillomacular bundle of the RNFL may be spared, even though mGCC thinning is present.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-011-0017-3</identifier><identifier>PMID: 21538002</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Clinical Investigation ; Eye ; Female ; Fibers ; Ganglion cells ; Glaucoma ; Glaucoma - diagnosis ; Gonioscopy ; Humans ; Intraocular Pressure - physiology ; Male ; Medicine ; Medicine & Public Health ; Microscopy, Acoustic ; Middle Aged ; Nerve Fibers - pathology ; Nerves ; Ophthalmology ; Optic Disk - pathology ; Optic Nerve Diseases - diagnosis ; Retina ; Retinal Ganglion Cells - pathology ; Thinning ; Tomography, Optical Coherence ; Visual Acuity - physiology ; Visual Field Tests ; Visual Fields</subject><ispartof>Japanese journal of ophthalmology, 2011-05, Vol.55 (3), p.228-234</ispartof><rights>Japanese Ophthalmological Society 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-2d13aa3d4625f06eef3d66f2dae4e1c09b8f950f2d6e1f3b9d6d0fbde0f410c13</citedby><cites>FETCH-LOGICAL-c427t-2d13aa3d4625f06eef3d66f2dae4e1c09b8f950f2d6e1f3b9d6d0fbde0f410c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-011-0017-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-011-0017-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21538002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kita, Yoshiyuki</creatorcontrib><creatorcontrib>Kita, Ritsuko</creatorcontrib><creatorcontrib>Nitta, Ai</creatorcontrib><creatorcontrib>Nishimura, Chiaki</creatorcontrib><creatorcontrib>Tomita, Goji</creatorcontrib><title>Glaucomatous eye macular ganglion cell complex thickness and its relation to temporal circumpapillary retinal nerve fiber layer thickness</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
To clarify the correlation between temporal circumpapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness in glaucomatous eyes.
Methods
Seventy-seven eyes of 77 subjects were categorized as normal, early glaucoma and moderate-to-advanced (moderate) glaucoma. After the circumpapillary RNFL thickness and mGCC thickness were measured, the temporal mean RNFL and mean mGCC were compared within the three groups. The study also investigated whether there was any correlation between the temporal RNFL and mGCC thicknesses.
Results
In the glaucoma groups, significant thinning of the temporal RNFL and mGCC thicknesses was noted. With the exception of the papillomacular bundle (
r
= −0.078), correlations were seen in each of the early glaucoma mGCC and temporal RNFL sectors (
r
= 0.38–0.753). Correlations were also noted for the mGCC and all temporal RNFL sectors in the moderate glaucoma group (
r
= 0.425–0.809).
Conclusions
From the early stage of glaucoma, similar decreases of the mGCC and RNFL occured, and a high correlation existed between the two. Therefore, like RNFL, mGCC can potentially be used to detect the early stages of glaucoma. However, in early glaucoma eyes, the papillomacular bundle of the RNFL may be spared, even though mGCC thinning is present.</description><subject>Clinical Investigation</subject><subject>Eye</subject><subject>Female</subject><subject>Fibers</subject><subject>Ganglion cells</subject><subject>Glaucoma</subject><subject>Glaucoma - diagnosis</subject><subject>Gonioscopy</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy, Acoustic</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Nerves</subject><subject>Ophthalmology</subject><subject>Optic Disk - pathology</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Retina</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Thinning</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity - physiology</subject><subject>Visual Field Tests</subject><subject>Visual Fields</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc9u1DAQhy0EosvCA3BBFhd6CczYjpMcUQUFqRIXOEeOPV5SnD_YScU-Am-N0y1FQoKLLXm--ayZH2PPEV4jQPUmIchaFYBYAGBVyAdshxplIYTSD9kOQGBRYlmesScpXQOAElI8ZmcCS1nn6o79vAxmtdNglmlNnI7EB2PXYCI_mPEQ-mnklkLgGZkD_eDL195-GyklbkbH-yXxSMEsG7dMfKFhnqLJeB_tOsxm7kN2HTO09GN-HyneEPd9R5EHc8znvfApe-RNSPTs7t6zL-_ffb74UFx9uvx48faqsEpUSyEcSmOkU1qUHjSRl05rL5whRWih6WrflJAfNKGXXeO0A985Aq8QLMo9e3XyznH6vlJa2qFP24xmpLyDtq6EUiDLJpPn_yURRA1VLcQmffkXej2tMU9868Om0Xnje4YnyMYppUi-nWM_5PVkU7sF2p4CbXOg7RZoK3PPizvx2g3k7jt-J5gBcQJSLo0Hin9-_rf1F-r8rjw</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Kita, Yoshiyuki</creator><creator>Kita, Ritsuko</creator><creator>Nitta, Ai</creator><creator>Nishimura, Chiaki</creator><creator>Tomita, Goji</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Glaucomatous eye macular ganglion cell complex thickness and its relation to temporal circumpapillary retinal nerve fiber layer thickness</title><author>Kita, Yoshiyuki ; Kita, Ritsuko ; Nitta, Ai ; Nishimura, Chiaki ; Tomita, Goji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-2d13aa3d4625f06eef3d66f2dae4e1c09b8f950f2d6e1f3b9d6d0fbde0f410c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Clinical Investigation</topic><topic>Eye</topic><topic>Female</topic><topic>Fibers</topic><topic>Ganglion cells</topic><topic>Glaucoma</topic><topic>Glaucoma - diagnosis</topic><topic>Gonioscopy</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy, Acoustic</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Nerves</topic><topic>Ophthalmology</topic><topic>Optic Disk - pathology</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Retina</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Thinning</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><topic>Visual Field Tests</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kita, Yoshiyuki</creatorcontrib><creatorcontrib>Kita, Ritsuko</creatorcontrib><creatorcontrib>Nitta, Ai</creatorcontrib><creatorcontrib>Nishimura, Chiaki</creatorcontrib><creatorcontrib>Tomita, Goji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Databases</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kita, Yoshiyuki</au><au>Kita, Ritsuko</au><au>Nitta, Ai</au><au>Nishimura, Chiaki</au><au>Tomita, Goji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glaucomatous eye macular ganglion cell complex thickness and its relation to temporal circumpapillary retinal nerve fiber layer thickness</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>55</volume><issue>3</issue><spage>228</spage><epage>234</epage><pages>228-234</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract>Purpose
To clarify the correlation between temporal circumpapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (mGCC) thickness in glaucomatous eyes.
Methods
Seventy-seven eyes of 77 subjects were categorized as normal, early glaucoma and moderate-to-advanced (moderate) glaucoma. After the circumpapillary RNFL thickness and mGCC thickness were measured, the temporal mean RNFL and mean mGCC were compared within the three groups. The study also investigated whether there was any correlation between the temporal RNFL and mGCC thicknesses.
Results
In the glaucoma groups, significant thinning of the temporal RNFL and mGCC thicknesses was noted. With the exception of the papillomacular bundle (
r
= −0.078), correlations were seen in each of the early glaucoma mGCC and temporal RNFL sectors (
r
= 0.38–0.753). Correlations were also noted for the mGCC and all temporal RNFL sectors in the moderate glaucoma group (
r
= 0.425–0.809).
Conclusions
From the early stage of glaucoma, similar decreases of the mGCC and RNFL occured, and a high correlation existed between the two. Therefore, like RNFL, mGCC can potentially be used to detect the early stages of glaucoma. However, in early glaucoma eyes, the papillomacular bundle of the RNFL may be spared, even though mGCC thinning is present.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>21538002</pmid><doi>10.1007/s10384-011-0017-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Japanese journal of ophthalmology, 2011-05, Vol.55 (3), p.228-234 |
| issn | 0021-5155 1613-2246 |
| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Clinical Investigation Eye Female Fibers Ganglion cells Glaucoma Glaucoma - diagnosis Gonioscopy Humans Intraocular Pressure - physiology Male Medicine Medicine & Public Health Microscopy, Acoustic Middle Aged Nerve Fibers - pathology Nerves Ophthalmology Optic Disk - pathology Optic Nerve Diseases - diagnosis Retina Retinal Ganglion Cells - pathology Thinning Tomography, Optical Coherence Visual Acuity - physiology Visual Field Tests Visual Fields |
| title | Glaucomatous eye macular ganglion cell complex thickness and its relation to temporal circumpapillary retinal nerve fiber layer thickness |
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