Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight
Summary Background Nonalcoholic fatty liver disease (NAFLD) is generally regarded as affecting the overweight or obese. Though previously reported, the notion that NAFLD occurs in the presence of normal body weight (adult BMI < 25) is unfamiliar in adults and problematic in children. Normal-body-...
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| Veröffentlicht in: | Clinics and research in hepatology and gastroenterology 2011-06, Vol.35 (6), p.500-505 |
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| creator | Yap, Jason Y.K O’Connor, Constance Mager, Diana R Taylor, Glenn Roberts, Eve A |
| description | Summary Background Nonalcoholic fatty liver disease (NAFLD) is generally regarded as affecting the overweight or obese. Though previously reported, the notion that NAFLD occurs in the presence of normal body weight (adult BMI < 25) is unfamiliar in adults and problematic in children. Normal-body-weight NAFLD accounts for approximately 15% of all NAFLD and may be more prevalent with certain ethnicities. Case We describe a case of a child who appeared to have normal-body-weight NAFLD, on the basis of typical age of presentation, ultrasonographically evident hepatic steatosis and compatible liver histology, including a NAFLD activity score of 7, but was shown conclusively to have cystic fibrosis. Further we present a clinical strategy for diagnosis of childhood NAFLD, which would discriminate between this patient and actual normal-body-weight NAFLD children in our clinical practice. Conclusion NAFLD requires affirmative diagnostic criteria and should not be merely a diagnosis of exclusion. |
| doi_str_mv | 10.1016/j.clinre.2011.04.001 |
| format | Article |
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Though previously reported, the notion that NAFLD occurs in the presence of normal body weight (adult BMI < 25) is unfamiliar in adults and problematic in children. Normal-body-weight NAFLD accounts for approximately 15% of all NAFLD and may be more prevalent with certain ethnicities. Case We describe a case of a child who appeared to have normal-body-weight NAFLD, on the basis of typical age of presentation, ultrasonographically evident hepatic steatosis and compatible liver histology, including a NAFLD activity score of 7, but was shown conclusively to have cystic fibrosis. Further we present a clinical strategy for diagnosis of childhood NAFLD, which would discriminate between this patient and actual normal-body-weight NAFLD children in our clinical practice. Conclusion NAFLD requires affirmative diagnostic criteria and should not be merely a diagnosis of exclusion.</description><identifier>ISSN: 2210-7401</identifier><identifier>EISSN: 2210-741X</identifier><identifier>DOI: 10.1016/j.clinre.2011.04.001</identifier><identifier>PMID: 21600867</identifier><language>eng</language><publisher>Issy-les-Moulineaux: Elsevier Masson</publisher><subject>Abdominal Pain - etiology ; Alanine Transaminase - blood ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Biopsy ; Body Mass Index ; Ceruloplasmin - analysis ; Child ; Copper - blood ; Cystic Fibrosis - diagnosis ; Cystic Fibrosis - genetics ; Diarrhea - etiology ; Fatty Liver - diagnosis ; Fatty Liver - etiology ; Female ; Gastroenterology and Hepatology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatomegaly - diagnostic imaging ; Humans ; Internal Medicine ; Liver - pathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Non-alcoholic Fatty Liver Disease ; Other diseases. Semiology ; Ultrasonography</subject><ispartof>Clinics and research in hepatology and gastroenterology, 2011-06, Vol.35 (6), p.500-505</ispartof><rights>Elsevier Masson SAS</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-fc8f16d7b68180215ea593930f86c4cc4a46cc54a0415f996138c3d22f61889d3</citedby><cites>FETCH-LOGICAL-c391t-fc8f16d7b68180215ea593930f86c4cc4a46cc54a0415f996138c3d22f61889d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24253600$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21600867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yap, Jason Y.K</creatorcontrib><creatorcontrib>O’Connor, Constance</creatorcontrib><creatorcontrib>Mager, Diana R</creatorcontrib><creatorcontrib>Taylor, Glenn</creatorcontrib><creatorcontrib>Roberts, Eve A</creatorcontrib><title>Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight</title><title>Clinics and research in hepatology and gastroenterology</title><addtitle>Clin Res Hepatol Gastroenterol</addtitle><description>Summary Background Nonalcoholic fatty liver disease (NAFLD) is generally regarded as affecting the overweight or obese. Though previously reported, the notion that NAFLD occurs in the presence of normal body weight (adult BMI < 25) is unfamiliar in adults and problematic in children. Normal-body-weight NAFLD accounts for approximately 15% of all NAFLD and may be more prevalent with certain ethnicities. Case We describe a case of a child who appeared to have normal-body-weight NAFLD, on the basis of typical age of presentation, ultrasonographically evident hepatic steatosis and compatible liver histology, including a NAFLD activity score of 7, but was shown conclusively to have cystic fibrosis. Further we present a clinical strategy for diagnosis of childhood NAFLD, which would discriminate between this patient and actual normal-body-weight NAFLD children in our clinical practice. Conclusion NAFLD requires affirmative diagnostic criteria and should not be merely a diagnosis of exclusion.</description><subject>Abdominal Pain - etiology</subject><subject>Alanine Transaminase - blood</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Body Mass Index</subject><subject>Ceruloplasmin - analysis</subject><subject>Child</subject><subject>Copper - blood</subject><subject>Cystic Fibrosis - diagnosis</subject><subject>Cystic Fibrosis - genetics</subject><subject>Diarrhea - etiology</subject><subject>Fatty Liver - diagnosis</subject><subject>Fatty Liver - etiology</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatomegaly - diagnostic imaging</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Liver - pathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Non-alcoholic Fatty Liver Disease</subject><subject>Other diseases. Semiology</subject><subject>Ultrasonography</subject><issn>2210-7401</issn><issn>2210-741X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFvFCEUxyfGxja138CYuRj1sCMPGIa5mDStVZONHmwTTxLKPHZZWWhhtma_vYyzthyAhN__PfJ7VfUKSAMExIdNY7wLCRtKABrCG0LgWXVCKZBFx-Hn88c7gePqLOcNKYu3RHbwojqmIAiRojupfl06vQoxj87UZq29x7DCXEdbhxi0N3EdfXmyehz3tXcPmOrBZdQZ63ffzq-Wl-9rF0rS-SFhmHNpq339B91qPb6sjqz2Gc8O52l1c_Xp-uLLYvn989eL8-XCsB7GhTXSghi6WyFBEgot6rZnPSNWCsON4ZoLY1quCYfW9r0AJg0bKLUCpOwHdlq9nevepXi_wzyqrcsGvdcB4y4r2VHOykYLyWfSpJhzQqvuktvqtFdA1ORWbdTsVk1uFeGquC2x14cGu9stDo-h_yYL8OYA6Gy0t0kH4_ITx2nLClq4jzOHRceDw_SvmyuR37jHvIm7VLxnBSpTRdSPaYzTFAGmb3Q9-wurqZdT</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Yap, Jason Y.K</creator><creator>O’Connor, Constance</creator><creator>Mager, Diana R</creator><creator>Taylor, Glenn</creator><creator>Roberts, Eve A</creator><general>Elsevier Masson</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight</title><author>Yap, Jason Y.K ; O’Connor, Constance ; Mager, Diana R ; Taylor, Glenn ; Roberts, Eve A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-fc8f16d7b68180215ea593930f86c4cc4a46cc54a0415f996138c3d22f61889d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal Pain - etiology</topic><topic>Alanine Transaminase - blood</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Body Mass Index</topic><topic>Ceruloplasmin - analysis</topic><topic>Child</topic><topic>Copper - blood</topic><topic>Cystic Fibrosis - diagnosis</topic><topic>Cystic Fibrosis - genetics</topic><topic>Diarrhea - etiology</topic><topic>Fatty Liver - diagnosis</topic><topic>Fatty Liver - etiology</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatomegaly - diagnostic imaging</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Liver - pathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Non-alcoholic Fatty Liver Disease</topic><topic>Other diseases. Semiology</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yap, Jason Y.K</creatorcontrib><creatorcontrib>O’Connor, Constance</creatorcontrib><creatorcontrib>Mager, Diana R</creatorcontrib><creatorcontrib>Taylor, Glenn</creatorcontrib><creatorcontrib>Roberts, Eve A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinics and research in hepatology and gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yap, Jason Y.K</au><au>O’Connor, Constance</au><au>Mager, Diana R</au><au>Taylor, Glenn</au><au>Roberts, Eve A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight</atitle><jtitle>Clinics and research in hepatology and gastroenterology</jtitle><addtitle>Clin Res Hepatol Gastroenterol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>35</volume><issue>6</issue><spage>500</spage><epage>505</epage><pages>500-505</pages><issn>2210-7401</issn><eissn>2210-741X</eissn><abstract>Summary Background Nonalcoholic fatty liver disease (NAFLD) is generally regarded as affecting the overweight or obese. Though previously reported, the notion that NAFLD occurs in the presence of normal body weight (adult BMI < 25) is unfamiliar in adults and problematic in children. Normal-body-weight NAFLD accounts for approximately 15% of all NAFLD and may be more prevalent with certain ethnicities. Case We describe a case of a child who appeared to have normal-body-weight NAFLD, on the basis of typical age of presentation, ultrasonographically evident hepatic steatosis and compatible liver histology, including a NAFLD activity score of 7, but was shown conclusively to have cystic fibrosis. Further we present a clinical strategy for diagnosis of childhood NAFLD, which would discriminate between this patient and actual normal-body-weight NAFLD children in our clinical practice. Conclusion NAFLD requires affirmative diagnostic criteria and should not be merely a diagnosis of exclusion.</abstract><cop>Issy-les-Moulineaux</cop><pub>Elsevier Masson</pub><pmid>21600867</pmid><doi>10.1016/j.clinre.2011.04.001</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinics and research in hepatology and gastroenterology, 2011-06, Vol.35 (6), p.500-505 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Abdominal Pain - etiology Alanine Transaminase - blood Aspartate Aminotransferases - blood Biological and medical sciences Biopsy Body Mass Index Ceruloplasmin - analysis Child Copper - blood Cystic Fibrosis - diagnosis Cystic Fibrosis - genetics Diarrhea - etiology Fatty Liver - diagnosis Fatty Liver - etiology Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Hepatomegaly - diagnostic imaging Humans Internal Medicine Liver - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Non-alcoholic Fatty Liver Disease Other diseases. Semiology Ultrasonography |
| title | Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight |
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