The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections and hospitalizations in children aged 2 years revealed that fewer of the younger cohort (20.4% versus 79.3%; p 88% of all PICU admissions would not qualify for RSV prophylaxis under our established guidelin...
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| Veröffentlicht in: | European journal of pediatrics 2011-07, Vol.170 (7), p.907-913 |
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| creator | Butt, Michelle L. Symington, Amanda Janes, Marianne Elliott, LouAnn Steele, Susan Paes, Bosco A. |
| description | Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections and hospitalizations in children aged 2 years revealed that fewer of the younger cohort (20.4% versus 79.3%;
p
88% of all PICU admissions would not qualify for RSV prophylaxis under our established guidelines and 66% of the children aged ≤2 years were >36 weeks gestation and are not currently targeted for prophylaxis. The number of high-risk infants admitted to PICU with RSV infection has likely plateaued, and further reductions in admission rates may only be realised with the use of universal, vaccine immunization programmes. |
| doi_str_mv | 10.1007/s00431-010-1376-3 |
| format | Article |
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p
< 0.001) had an underlying medical condition. RSV infection occurred in 3.3% (
n
= 6) children who had received palivizumab prophylaxis, and there were two deaths. The results indicate that >88% of all PICU admissions would not qualify for RSV prophylaxis under our established guidelines and 66% of the children aged ≤2 years were >36 weeks gestation and are not currently targeted for prophylaxis. The number of high-risk infants admitted to PICU with RSV infection has likely plateaued, and further reductions in admission rates may only be realised with the use of universal, vaccine immunization programmes.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-010-1376-3</identifier><identifier>PMID: 21174120</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Age ; Age Factors ; Antibodies, Monoclonal, Humanized - therapeutic use ; Antiviral Agents - therapeutic use ; Biological and medical sciences ; Cardiovascular disease ; Child ; Child, Preschool ; Congenital diseases ; Data collection ; Demographics ; Disease prevention ; Female ; General aspects ; Hospitalization ; Hospitals ; Human viral diseases ; Humans ; Immunization ; Immunization, Passive ; Infant ; Infant, Newborn ; Infections ; Infectious diseases ; Intensive care ; Intensive Care Units, Pediatric ; Lung diseases ; Male ; Medical records ; Medical sciences ; Medicine ; Medicine & Public Health ; Ontario ; Original Paper ; Palivizumab ; Patient Admission - statistics & numerical data ; Pediatrics ; Pneumonia ; Premature babies ; Premature birth ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - prevention & control ; Retrospective Studies ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Viral infections</subject><ispartof>European journal of pediatrics, 2011-07, Vol.170 (7), p.907-913</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-576b9baf3282f91c76efd27cc2fee1a0ea630236ddcc027c6eba0729a35c47743</citedby><cites>FETCH-LOGICAL-c444t-576b9baf3282f91c76efd27cc2fee1a0ea630236ddcc027c6eba0729a35c47743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00431-010-1376-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00431-010-1376-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24290068$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21174120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butt, Michelle L.</creatorcontrib><creatorcontrib>Symington, Amanda</creatorcontrib><creatorcontrib>Janes, Marianne</creatorcontrib><creatorcontrib>Elliott, LouAnn</creatorcontrib><creatorcontrib>Steele, Susan</creatorcontrib><creatorcontrib>Paes, Bosco A.</creatorcontrib><title>The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><addtitle>Eur J Pediatr</addtitle><description>Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections and hospitalizations in children aged <2 years. The aim of this retrospective, single-centre study was to examine the characteristics of patients admitted to a paediatric intensive care unit (PICU) with RSV infection following the implementation of a RSV prophylaxis programme. Electronic hospital medical records of all PICU admissions for RSV infection were searched from 2003 to 2009. Data on baseline demographics, underlying disease, criteria for hospitalization, respiratory diagnosis and management, complications and palivizumab prophylaxis were collected. A total of 181 patients were admitted with RSV infection, accounting for 5.7% of all admissions. Eighty-four percent were ≤2 years of age. Majority (70.2%) had no underlying medical illness, and 79.6% received antibiotics as part of their medical treatment. Comparison of children aged ≤2 years and those >2 years revealed that fewer of the younger cohort (20.4% versus 79.3%;
p
< 0.001) had an underlying medical condition. RSV infection occurred in 3.3% (
n
= 6) children who had received palivizumab prophylaxis, and there were two deaths. The results indicate that >88% of all PICU admissions would not qualify for RSV prophylaxis under our established guidelines and 66% of the children aged ≤2 years were >36 weeks gestation and are not currently targeted for prophylaxis. The number of high-risk infants admitted to PICU with RSV infection has likely plateaued, and further reductions in admission rates may only be realised with the use of universal, vaccine immunization programmes.</description><subject>Adolescent</subject><subject>Age</subject><subject>Age Factors</subject><subject>Antibodies, Monoclonal, Humanized - therapeutic use</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Congenital diseases</subject><subject>Data collection</subject><subject>Demographics</subject><subject>Disease prevention</subject><subject>Female</subject><subject>General aspects</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization, Passive</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Intensive care</subject><subject>Intensive Care Units, Pediatric</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ontario</subject><subject>Original Paper</subject><subject>Palivizumab</subject><subject>Patient Admission - statistics & numerical data</subject><subject>Pediatrics</subject><subject>Pneumonia</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Respiratory Syncytial Virus Infections - prevention & control</subject><subject>Retrospective Studies</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><subject>Viral infections</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUuLFDEUhYMoTjv6A9xIQMSN0ZtHJ5XZyeALBgQd3Rbp1M1MhupUmaQGe-NvN023DwRXITffOTmXQ8hjDi85gHlVAJTkDDgwLo1m8g5ZcSUF42D0XbICqYBpbu0JeVDKDTSN5d19ciI4N4oLWJEfl9dI43Z2vtIp0DlP8_VudN9joVOis8MhupqjpzFVTCXeIvUuI11SrNQN21hKnFKhYcr00-evDQvoaxudUUcz1jyVeT-4xRe0xHQ1IvOYanModRl2D8m94MaCj47nKfny9s3l-Xt28fHdh_PXF8wrpSpbG72xGxek6ESw3BuNYRDGexEQuQN0WoKQehi8hzbXuHFghHVy7ZUxSp6S5wfftuC3BUvtW3KP4-gSTkvpOyOU7ICbRj79h7yZlpxauJ6DXa-t7IxuFD9Qvi1YMoZ-znHr8q5B_b6b_tBND_t766aXTfPk6Lxstjj8VvwqowHPjoAr3o0hu-Rj-cMpYQF01zhx4Ep7SleY_474v99_AnHdp-I</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Butt, Michelle L.</creator><creator>Symington, Amanda</creator><creator>Janes, Marianne</creator><creator>Elliott, LouAnn</creator><creator>Steele, Susan</creator><creator>Paes, Bosco A.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study</title><author>Butt, Michelle L. ; Symington, Amanda ; Janes, Marianne ; Elliott, LouAnn ; Steele, Susan ; Paes, Bosco A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-576b9baf3282f91c76efd27cc2fee1a0ea630236ddcc027c6eba0729a35c47743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Age Factors</topic><topic>Antibodies, Monoclonal, Humanized - therapeutic use</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Congenital diseases</topic><topic>Data collection</topic><topic>Demographics</topic><topic>Disease prevention</topic><topic>Female</topic><topic>General aspects</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization, Passive</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intensive care</topic><topic>Intensive Care Units, Pediatric</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical records</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ontario</topic><topic>Original Paper</topic><topic>Palivizumab</topic><topic>Patient Admission - statistics & numerical data</topic><topic>Pediatrics</topic><topic>Pneumonia</topic><topic>Premature babies</topic><topic>Premature birth</topic><topic>Prevention and actions</topic><topic>Public health. 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The aim of this retrospective, single-centre study was to examine the characteristics of patients admitted to a paediatric intensive care unit (PICU) with RSV infection following the implementation of a RSV prophylaxis programme. Electronic hospital medical records of all PICU admissions for RSV infection were searched from 2003 to 2009. Data on baseline demographics, underlying disease, criteria for hospitalization, respiratory diagnosis and management, complications and palivizumab prophylaxis were collected. A total of 181 patients were admitted with RSV infection, accounting for 5.7% of all admissions. Eighty-four percent were ≤2 years of age. Majority (70.2%) had no underlying medical illness, and 79.6% received antibiotics as part of their medical treatment. Comparison of children aged ≤2 years and those >2 years revealed that fewer of the younger cohort (20.4% versus 79.3%;
p
< 0.001) had an underlying medical condition. RSV infection occurred in 3.3% (
n
= 6) children who had received palivizumab prophylaxis, and there were two deaths. The results indicate that >88% of all PICU admissions would not qualify for RSV prophylaxis under our established guidelines and 66% of the children aged ≤2 years were >36 weeks gestation and are not currently targeted for prophylaxis. The number of high-risk infants admitted to PICU with RSV infection has likely plateaued, and further reductions in admission rates may only be realised with the use of universal, vaccine immunization programmes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21174120</pmid><doi>10.1007/s00431-010-1376-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Age Age Factors Antibodies, Monoclonal, Humanized - therapeutic use Antiviral Agents - therapeutic use Biological and medical sciences Cardiovascular disease Child Child, Preschool Congenital diseases Data collection Demographics Disease prevention Female General aspects Hospitalization Hospitals Human viral diseases Humans Immunization Immunization, Passive Infant Infant, Newborn Infections Infectious diseases Intensive care Intensive Care Units, Pediatric Lung diseases Male Medical records Medical sciences Medicine Medicine & Public Health Ontario Original Paper Palivizumab Patient Admission - statistics & numerical data Pediatrics Pneumonia Premature babies Premature birth Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Respiratory syncytial virus Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - prevention & control Retrospective Studies Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral infections |
| title | The impact of prophylaxis on paediatric intensive care unit admissions for RSV infection: a retrospective, single-centre study |
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