Quantitative Coherent Anti-Stokes Raman Scattering (CARS) Microscopy

Quantitative Coherent Anti-Stokes Raman Scattering (CARS) Microscopy

The ability to observe samples qualitatively at the microscopic scale has greatly enhanced our understanding of the physical and biological world throughout the 400 year history of microscopic imaging, but there are relatively few techniques that can truly claim the ability to quantify the local con...

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Veröffentlicht in:The journal of physical chemistry. B 2011-06, Vol.115 (24), p.7713-7725
Hauptverfasser: Day, James P. R, Domke, Katrin F, Rago, Gianluca, Kano, Hideaki, Hamaguchi, Hiro-o, Vartiainen, Erik M, Bonn, Mischa
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Sprache:eng
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Adipocytes - metabolism
Fatty Acids - chemistry
Microscopy, Confocal
Spectrum Analysis, Raman - methods
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container_end_page 7725
container_issue 24
container_start_page 7713
container_title The journal of physical chemistry. B
container_volume 115
creator Day, James P. R
Domke, Katrin F
Rago, Gianluca
Kano, Hideaki
Hamaguchi, Hiro-o
Vartiainen, Erik M
Bonn, Mischa
description The ability to observe samples qualitatively at the microscopic scale has greatly enhanced our understanding of the physical and biological world throughout the 400 year history of microscopic imaging, but there are relatively few techniques that can truly claim the ability to quantify the local concentration and composition of a sample. We review coherent anti-Stokes Raman scattering (CARS) as a quantitative, chemically specific, and label-free microscopy. We discuss the complicating influence of the nonresonant response on the CARS signal and the various experimental and mathematical approaches that can be adopted to extract quantitative information from CARS. We also review the uses to which CARS has been employed as a quantitative microscopy to solve challenges in material and biological science.
doi_str_mv 10.1021/jp200606e
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subjects Adipocytes - metabolism
Fatty Acids - chemistry
Microscopy, Confocal
Spectrum Analysis, Raman - methods
title Quantitative Coherent Anti-Stokes Raman Scattering (CARS) Microscopy
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