MicroRNA expression profiling in neurogenesis of adipose tissue-derived stem cells
Adipose tissue-derived stem cells (ADSCs) are one population of adult stem cells that can self renew and differentiate into multiple lineages. Because of advantages in method and quantity of acquisition, ADSCs are gaining attention as an alternative source of bone marrow mesenchymal stem cells. In t...
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| Veröffentlicht in: | Journal of genetics 2011-04, Vol.90 (1), p.81-93 |
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| creator | CHO, JUNG AH PARK, HO LIM, EUN HYE LEE, KYO WON |
| description | Adipose tissue-derived stem cells (ADSCs) are one population of adult stem cells that can self renew and differentiate into multiple lineages. Because of advantages in method and quantity of acquisition, ADSCs are gaining attention as an alternative source of bone marrow mesenchymal stem cells. In this study, we performed microRNA profiling of undifferentiated and of neurally-differentiated ADSCs to identify the responsible microRNAs in neurogenesis using this type of stem cell. MicroRNAs from four different donors were analysed by microarray. Compared to the undifferentiation control, we identified 39–101 microRNAs with more than two-fold higher expression and 3–9 microRNAs with two-fold lower expression. The identified microRNAs were further analysed in terms of gene ontology (GO) in relation with neurogenesis, based on their target mRNAs predicted by computational analysis. This study revealed the specific microRNAs involved in neurogenesis via microRNA microarray, and may provide the basic information for genetic induction of adult stem cell differentiation using microRNAs. |
| doi_str_mv | 10.1007/s12041-011-0041-6 |
| format | Article |
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Because of advantages in method and quantity of acquisition, ADSCs are gaining attention as an alternative source of bone marrow mesenchymal stem cells. In this study, we performed microRNA profiling of undifferentiated and of neurally-differentiated ADSCs to identify the responsible microRNAs in neurogenesis using this type of stem cell. MicroRNAs from four different donors were analysed by microarray. Compared to the undifferentiation control, we identified 39–101 microRNAs with more than two-fold higher expression and 3–9 microRNAs with two-fold lower expression. The identified microRNAs were further analysed in terms of gene ontology (GO) in relation with neurogenesis, based on their target mRNAs predicted by computational analysis. This study revealed the specific microRNAs involved in neurogenesis via microRNA microarray, and may provide the basic information for genetic induction of adult stem cell differentiation using microRNAs.</description><identifier>ISSN: 0022-1333</identifier><identifier>EISSN: 0973-7731</identifier><identifier>DOI: 10.1007/s12041-011-0041-6</identifier><identifier>PMID: 21677392</identifier><language>eng</language><publisher>India: Springer-Verlag</publisher><subject>Adipose Tissue - cytology ; adult stem cells ; adults ; Animal Genetics and Genomics ; Biomedical and Life Sciences ; Body fat ; bone marrow ; cell differentiation ; Evolutionary Biology ; Gene expression ; Gene Expression Profiling ; gene expression regulation ; genes ; Genetics ; Humans ; Life Sciences ; messenger RNA ; microarray technology ; Microbial Genetics and Genomics ; microRNA ; MicroRNAs - genetics ; neurogenesis ; Neurogenesis - genetics ; Plant Genetics and Genomics ; Research Article ; Ribonucleic acid ; RNA ; Stem cells ; Stem Cells - cytology ; Stromal Cells - cytology</subject><ispartof>Journal of genetics, 2011-04, Vol.90 (1), p.81-93</ispartof><rights>Indian Academy of Sciences 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-2c248a222b6b5fb7e4d14aefde32277e08e0b277bdba5f753488a622b2d37af73</citedby><cites>FETCH-LOGICAL-c427t-2c248a222b6b5fb7e4d14aefde32277e08e0b277bdba5f753488a622b2d37af73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12041-011-0041-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12041-011-0041-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21677392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHO, JUNG AH</creatorcontrib><creatorcontrib>PARK, HO</creatorcontrib><creatorcontrib>LIM, EUN HYE</creatorcontrib><creatorcontrib>LEE, KYO WON</creatorcontrib><title>MicroRNA expression profiling in neurogenesis of adipose tissue-derived stem cells</title><title>Journal of genetics</title><addtitle>J Genet</addtitle><addtitle>J Genet</addtitle><description>Adipose tissue-derived stem cells (ADSCs) are one population of adult stem cells that can self renew and differentiate into multiple lineages. Because of advantages in method and quantity of acquisition, ADSCs are gaining attention as an alternative source of bone marrow mesenchymal stem cells. In this study, we performed microRNA profiling of undifferentiated and of neurally-differentiated ADSCs to identify the responsible microRNAs in neurogenesis using this type of stem cell. MicroRNAs from four different donors were analysed by microarray. Compared to the undifferentiation control, we identified 39–101 microRNAs with more than two-fold higher expression and 3–9 microRNAs with two-fold lower expression. The identified microRNAs were further analysed in terms of gene ontology (GO) in relation with neurogenesis, based on their target mRNAs predicted by computational analysis. This study revealed the specific microRNAs involved in neurogenesis via microRNA microarray, and may provide the basic information for genetic induction of adult stem cell differentiation using microRNAs.</description><subject>Adipose Tissue - cytology</subject><subject>adult stem cells</subject><subject>adults</subject><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Body fat</subject><subject>bone marrow</subject><subject>cell differentiation</subject><subject>Evolutionary Biology</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>gene expression regulation</subject><subject>genes</subject><subject>Genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>messenger RNA</subject><subject>microarray technology</subject><subject>Microbial Genetics and Genomics</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>neurogenesis</subject><subject>Neurogenesis - genetics</subject><subject>Plant Genetics and Genomics</subject><subject>Research Article</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stromal Cells - cytology</subject><issn>0022-1333</issn><issn>0973-7731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1PGzEQhq2qqEDoD-iltbjAZYu_dr05RlELSLSVgJwtb3YcGSXr1JNF8O-Z1dIicYgly2P5mXfG8zL2RYrvUgh7gVIJIwshaQ9B9YEdianVhbVafqRYKFVIrfUhO0Z8GK5WqE_sUMmKkKk6Yre_4jKn298zDk_bDIgxdXybU4jr2K147HgHfU4r6AAj8hS4b-M2IfBdROyhaCHHR2g57mDDl7Be4wk7CH6N8Pn1nLDFzx_386vi5s_l9Xx2UyyNsrtCLZWpvVKqqZoyNBZMK42H0IKmNi2IGkRDQdM2vgy21KaufUW4arX1weoJOxt1qd2_PeDObSIOHfgOUo-utspoU01LIs_3kpIGU1ZaTyWhp-_Qh9Tnjv5BemUla2tqguQI0egQMwS3zXHj8zMpucEZNzrjyBk3OOMqyvn6Ktw3G2j_Z_yzggA1AkhP3QryW-V9qt_GpOCT86sc0S3ulJClEFLoYb0AnkihMw</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>CHO, JUNG AH</creator><creator>PARK, HO</creator><creator>LIM, EUN HYE</creator><creator>LEE, KYO WON</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QO</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>MicroRNA expression profiling in neurogenesis of adipose tissue-derived stem cells</title><author>CHO, JUNG AH ; PARK, HO ; LIM, EUN HYE ; LEE, KYO WON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-2c248a222b6b5fb7e4d14aefde32277e08e0b277bdba5f753488a622b2d37af73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose Tissue - cytology</topic><topic>adult stem cells</topic><topic>adults</topic><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Body fat</topic><topic>bone marrow</topic><topic>cell differentiation</topic><topic>Evolutionary Biology</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>gene expression regulation</topic><topic>genes</topic><topic>Genetics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>messenger RNA</topic><topic>microarray technology</topic><topic>Microbial Genetics and Genomics</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>neurogenesis</topic><topic>Neurogenesis - genetics</topic><topic>Plant Genetics and Genomics</topic><topic>Research Article</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stromal Cells - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHO, JUNG AH</creatorcontrib><creatorcontrib>PARK, HO</creatorcontrib><creatorcontrib>LIM, EUN HYE</creatorcontrib><creatorcontrib>LEE, KYO WON</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHO, JUNG AH</au><au>PARK, HO</au><au>LIM, EUN HYE</au><au>LEE, KYO WON</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA expression profiling in neurogenesis of adipose tissue-derived stem cells</atitle><jtitle>Journal of genetics</jtitle><stitle>J Genet</stitle><addtitle>J Genet</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>90</volume><issue>1</issue><spage>81</spage><epage>93</epage><pages>81-93</pages><issn>0022-1333</issn><eissn>0973-7731</eissn><abstract>Adipose tissue-derived stem cells (ADSCs) are one population of adult stem cells that can self renew and differentiate into multiple lineages. Because of advantages in method and quantity of acquisition, ADSCs are gaining attention as an alternative source of bone marrow mesenchymal stem cells. In this study, we performed microRNA profiling of undifferentiated and of neurally-differentiated ADSCs to identify the responsible microRNAs in neurogenesis using this type of stem cell. MicroRNAs from four different donors were analysed by microarray. Compared to the undifferentiation control, we identified 39–101 microRNAs with more than two-fold higher expression and 3–9 microRNAs with two-fold lower expression. The identified microRNAs were further analysed in terms of gene ontology (GO) in relation with neurogenesis, based on their target mRNAs predicted by computational analysis. This study revealed the specific microRNAs involved in neurogenesis via microRNA microarray, and may provide the basic information for genetic induction of adult stem cell differentiation using microRNAs.</abstract><cop>India</cop><pub>Springer-Verlag</pub><pmid>21677392</pmid><doi>10.1007/s12041-011-0041-6</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of genetics, 2011-04, Vol.90 (1), p.81-93 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Indian Academy of Sciences; SpringerLink Journals - AutoHoldings |
| subjects | Adipose Tissue - cytology adult stem cells adults Animal Genetics and Genomics Biomedical and Life Sciences Body fat bone marrow cell differentiation Evolutionary Biology Gene expression Gene Expression Profiling gene expression regulation genes Genetics Humans Life Sciences messenger RNA microarray technology Microbial Genetics and Genomics microRNA MicroRNAs - genetics neurogenesis Neurogenesis - genetics Plant Genetics and Genomics Research Article Ribonucleic acid RNA Stem cells Stem Cells - cytology Stromal Cells - cytology |
| title | MicroRNA expression profiling in neurogenesis of adipose tissue-derived stem cells |
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