AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

AAA+ family proteolytic machines (ClpXP, ClpAP, ClpCP, HslUV, Lon, FtsH, PAN 20S, and the 26S proteasome) perform protein quality control and are used in regulatory circuits in all cells. These machines contain a compartmental protease, with active sites sequestered in an interior chamber, and a hex...

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Veröffentlicht in:	Annual review of biochemistry 2011-07, Vol.80 (1), p.587-612
Hauptverfasser:	Sauer, Robert T, Baker, Tania A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphate - metabolism ATP ATP-Dependent Proteases - chemistry ATP-Dependent Proteases - genetics ATP-Dependent Proteases - metabolism Catalytic Domain disassembly Models, Molecular Molecules Nucleotides - metabolism Proteases proteasome Protein Conformation protein degradation Protein Denaturation protein translocation Protein Transport protein unfolding Proteins Quality control Substrate Specificity Substrates Translocation
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