Intestinal homeostasis and its breakdown in inflammatory bowel disease
Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found...
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| Veröffentlicht in: | Nature (London) 2011-06, Vol.474 (7351), p.298-306 |
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| creator | Maloy, Kevin J. Powrie, Fiona |
| description | Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease. |
| doi_str_mv | 10.1038/nature10208 |
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Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature10208</identifier><identifier>PMID: 21677746</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/420/2780 ; 692/699/1503/1581/257 ; Animals ; Autophagy ; Development and progression ; Epithelium - metabolism ; Epithelium - pathology ; Epithelium - physiopathology ; Health aspects ; Homeostasis ; Humanities and Social Sciences ; Humans ; Immune system ; Inflammation - immunology ; Inflammation - pathology ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - genetics ; Inflammatory Bowel Diseases - immunology ; Inflammatory Bowel Diseases - pathology ; Inflammatory Bowel Diseases - physiopathology ; Intestinal Mucosa - cytology ; Intestinal Mucosa - immunology ; Intestinal Mucosa - pathology ; Intestinal Mucosa - physiopathology ; Intestines - immunology ; Intestines - metabolism ; Intestines - microbiology ; Intestines - physiopathology ; Microbiota (Symbiotic organisms) ; Models, Biological ; multidisciplinary ; Pathology ; Receptors, Pattern Recognition - metabolism ; review-article ; Science ; Science (multidisciplinary) ; Small intestine ; Studies</subject><ispartof>Nature (London), 2011-06, Vol.474 (7351), p.298-306</ispartof><rights>Springer Nature Limited 2011</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 16, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-6829f888f8188ee4878e6a3c888ba8b58e812cdc177f11105b83c7a045c64d323</citedby><cites>FETCH-LOGICAL-c620t-6829f888f8188ee4878e6a3c888ba8b58e812cdc177f11105b83c7a045c64d323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21677746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maloy, Kevin J.</creatorcontrib><creatorcontrib>Powrie, Fiona</creatorcontrib><title>Intestinal homeostasis and its breakdown in inflammatory bowel disease</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease.</description><subject>692/420/2780</subject><subject>692/699/1503/1581/257</subject><subject>Animals</subject><subject>Autophagy</subject><subject>Development and progression</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - pathology</subject><subject>Epithelium - physiopathology</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immune system</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - genetics</subject><subject>Inflammatory Bowel Diseases - immunology</subject><subject>Inflammatory Bowel Diseases - 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maloy, Kevin J.</au><au>Powrie, Fiona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal homeostasis and its breakdown in inflammatory bowel disease</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>2011-06</date><risdate>2011</risdate><volume>474</volume><issue>7351</issue><spage>298</spage><epage>306</epage><pages>298-306</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. 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| subjects | 692/420/2780 692/699/1503/1581/257 Animals Autophagy Development and progression Epithelium - metabolism Epithelium - pathology Epithelium - physiopathology Health aspects Homeostasis Humanities and Social Sciences Humans Immune system Inflammation - immunology Inflammation - pathology Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - physiopathology Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestinal Mucosa - physiopathology Intestines - immunology Intestines - metabolism Intestines - microbiology Intestines - physiopathology Microbiota (Symbiotic organisms) Models, Biological multidisciplinary Pathology Receptors, Pattern Recognition - metabolism review-article Science Science (multidisciplinary) Small intestine Studies |
| title | Intestinal homeostasis and its breakdown in inflammatory bowel disease |
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