Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas
► LXR gene expression is not significantly different in pituitary adenomas. ► LXR-α/β ratio is significantly elevated in ACTH-secreting pituitary adenomas. ► LXR-β deteriorates POMC gene promoter activity in AtT-20 cells. The liver X receptors (LXR-α and -β) are nuclear oxysterol receptors that play...
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| Veröffentlicht in: | Neuroscience letters 2011-04, Vol.494 (1), p.34-37 |
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| creator | Hashimoto, Koshi Matsumoto, Shunichi Ishida, Emi Miura, Atsuko Horiguchi, Kazuhiko Ozawa, Atsushi Shibusawa, Nobuyuki Satoh, Teturou Yamada, Masanobu Yamada, Shozo Mori, Masatomo |
| description | ► LXR gene expression is not significantly different in pituitary adenomas. ► LXR-α/β ratio is significantly elevated in ACTH-secreting pituitary adenomas. ► LXR-β deteriorates POMC gene promoter activity in AtT-20 cells.
The liver X receptors (LXR-α and -β) are nuclear oxysterol receptors that play pivotal roles in regulating the expression of genes involved in cholesterol transport and metabolism. Recently, several groups have reported that the LXRs also regulate adrenal steroidogenesis. In the previous report, we demonstrated that LXR-α is dominantly expressed in the pituitary and that LXR-α positively regulates the proopiomelanocortin (POMC) gene promoter at the transcriptional level. In this report, we evaluated the expression levels of LXR-α and -β gene in the human pituitary tumor. Even though LXR-α mRNA levels are not significantly increased in ACTH-secreting adenomas, LXR-α/β expression ratio is significantly higher than other pituitary tumors including normal pituitaries. Furthermore, in At-T20 cells, which express POMC gene, overexpression of LXR-β decreased POMC gene promoter activities. Thus, we concluded that LXR-α/β gene expression ratio is a critical factor to activate POMC gene expression in ACTH-secreting pituitary adenomas. |
| doi_str_mv | 10.1016/j.neulet.2011.02.048 |
| format | Article |
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The liver X receptors (LXR-α and -β) are nuclear oxysterol receptors that play pivotal roles in regulating the expression of genes involved in cholesterol transport and metabolism. Recently, several groups have reported that the LXRs also regulate adrenal steroidogenesis. In the previous report, we demonstrated that LXR-α is dominantly expressed in the pituitary and that LXR-α positively regulates the proopiomelanocortin (POMC) gene promoter at the transcriptional level. In this report, we evaluated the expression levels of LXR-α and -β gene in the human pituitary tumor. Even though LXR-α mRNA levels are not significantly increased in ACTH-secreting adenomas, LXR-α/β expression ratio is significantly higher than other pituitary tumors including normal pituitaries. Furthermore, in At-T20 cells, which express POMC gene, overexpression of LXR-β decreased POMC gene promoter activities. Thus, we concluded that LXR-α/β gene expression ratio is a critical factor to activate POMC gene expression in ACTH-secreting pituitary adenomas.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2011.02.048</identifier><identifier>PMID: 21356276</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>ACTH-secreting pituitary adenoma ; ACTH-Secreting Pituitary Adenoma - genetics ; ACTH-Secreting Pituitary Adenoma - metabolism ; Adenoma - genetics ; Adenoma - metabolism ; Adenoma - secretion ; Adrenocorticotropic Hormone - secretion ; Adult ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Human pituitary adenomas ; Humans ; Liver X receptor ; Liver X Receptors ; Male ; Middle Aged ; Orphan Nuclear Receptors - genetics ; Orphan Nuclear Receptors - metabolism ; POMC gene expression ; Pro-Opiomelanocortin - genetics ; Pro-Opiomelanocortin - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2011-04, Vol.494 (1), p.34-37</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-5574e3e2a3becb924b7354424fc18124879479b90b1f93402c9bcfd8ddedd4863</citedby><cites>FETCH-LOGICAL-c423t-5574e3e2a3becb924b7354424fc18124879479b90b1f93402c9bcfd8ddedd4863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2011.02.048$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24061290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21356276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashimoto, Koshi</creatorcontrib><creatorcontrib>Matsumoto, Shunichi</creatorcontrib><creatorcontrib>Ishida, Emi</creatorcontrib><creatorcontrib>Miura, Atsuko</creatorcontrib><creatorcontrib>Horiguchi, Kazuhiko</creatorcontrib><creatorcontrib>Ozawa, Atsushi</creatorcontrib><creatorcontrib>Shibusawa, Nobuyuki</creatorcontrib><creatorcontrib>Satoh, Teturou</creatorcontrib><creatorcontrib>Yamada, Masanobu</creatorcontrib><creatorcontrib>Yamada, Shozo</creatorcontrib><creatorcontrib>Mori, Masatomo</creatorcontrib><title>Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>► LXR gene expression is not significantly different in pituitary adenomas. ► LXR-α/β ratio is significantly elevated in ACTH-secreting pituitary adenomas. ► LXR-β deteriorates POMC gene promoter activity in AtT-20 cells.
The liver X receptors (LXR-α and -β) are nuclear oxysterol receptors that play pivotal roles in regulating the expression of genes involved in cholesterol transport and metabolism. Recently, several groups have reported that the LXRs also regulate adrenal steroidogenesis. In the previous report, we demonstrated that LXR-α is dominantly expressed in the pituitary and that LXR-α positively regulates the proopiomelanocortin (POMC) gene promoter at the transcriptional level. In this report, we evaluated the expression levels of LXR-α and -β gene in the human pituitary tumor. Even though LXR-α mRNA levels are not significantly increased in ACTH-secreting adenomas, LXR-α/β expression ratio is significantly higher than other pituitary tumors including normal pituitaries. Furthermore, in At-T20 cells, which express POMC gene, overexpression of LXR-β decreased POMC gene promoter activities. Thus, we concluded that LXR-α/β gene expression ratio is a critical factor to activate POMC gene expression in ACTH-secreting pituitary adenomas.</description><subject>ACTH-secreting pituitary adenoma</subject><subject>ACTH-Secreting Pituitary Adenoma - genetics</subject><subject>ACTH-Secreting Pituitary Adenoma - metabolism</subject><subject>Adenoma - genetics</subject><subject>Adenoma - metabolism</subject><subject>Adenoma - secretion</subject><subject>Adrenocorticotropic Hormone - secretion</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human pituitary adenomas</subject><subject>Humans</subject><subject>Liver X receptor</subject><subject>Liver X Receptors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Orphan Nuclear Receptors - genetics</subject><subject>Orphan Nuclear Receptors - metabolism</subject><subject>POMC gene expression</subject><subject>Pro-Opiomelanocortin - genetics</subject><subject>Pro-Opiomelanocortin - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3DAQgEVpaTZp36AUXUpOdvQz_tElEJbmBxZ6SaE9CVkaFy1e25Hk0D5W8yB5pijspr21pxmGb2akbwj5wFnJGa_PtuWIy4CpFIzzkomSQfuKrHjbiKJRjXhNVkwyKKQCdkSOY9wyxipewVtyJLisatHUK_J94-8x0G80oMU5TaF4_H32-EDx5xwwRj-NNJjkJ-oj9aMNaCK6nNGL9e11ETFXkh9_0NmnxScTflHjcJx2Jr4jb3ozRHx_iCfk6-Xn2_V1sflydbO-2BQWhExFVTWAEoWRHdpOCegaWQEI6C1vuYC2UdCoTrGO90oCE1Z1tnetc-gctLU8Iaf7uXOY7haMSe98tDgMZsRpiTr74CBULf5PVgpUNqMyCXvShinGgL2eg9_l32nO9LN9vdV7-_rZvmZCZ_u57eNhwdLt0P1petGdgU8HwERrhj6Y0fr4lwNWc6FY5s73HGZx9x6DjtbjaNH5fKek3eT__ZIn5-2lwA</recordid><startdate>20110420</startdate><enddate>20110420</enddate><creator>Hashimoto, Koshi</creator><creator>Matsumoto, Shunichi</creator><creator>Ishida, Emi</creator><creator>Miura, Atsuko</creator><creator>Horiguchi, Kazuhiko</creator><creator>Ozawa, Atsushi</creator><creator>Shibusawa, Nobuyuki</creator><creator>Satoh, Teturou</creator><creator>Yamada, Masanobu</creator><creator>Yamada, Shozo</creator><creator>Mori, Masatomo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110420</creationdate><title>Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas</title><author>Hashimoto, Koshi ; Matsumoto, Shunichi ; Ishida, Emi ; Miura, Atsuko ; Horiguchi, Kazuhiko ; Ozawa, Atsushi ; Shibusawa, Nobuyuki ; Satoh, Teturou ; Yamada, Masanobu ; Yamada, Shozo ; Mori, Masatomo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-5574e3e2a3becb924b7354424fc18124879479b90b1f93402c9bcfd8ddedd4863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>ACTH-secreting pituitary adenoma</topic><topic>ACTH-Secreting Pituitary Adenoma - genetics</topic><topic>ACTH-Secreting Pituitary Adenoma - metabolism</topic><topic>Adenoma - genetics</topic><topic>Adenoma - metabolism</topic><topic>Adenoma - secretion</topic><topic>Adrenocorticotropic Hormone - secretion</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human pituitary adenomas</topic><topic>Humans</topic><topic>Liver X receptor</topic><topic>Liver X Receptors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Orphan Nuclear Receptors - genetics</topic><topic>Orphan Nuclear Receptors - metabolism</topic><topic>POMC gene expression</topic><topic>Pro-Opiomelanocortin - genetics</topic><topic>Pro-Opiomelanocortin - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashimoto, Koshi</creatorcontrib><creatorcontrib>Matsumoto, Shunichi</creatorcontrib><creatorcontrib>Ishida, Emi</creatorcontrib><creatorcontrib>Miura, Atsuko</creatorcontrib><creatorcontrib>Horiguchi, Kazuhiko</creatorcontrib><creatorcontrib>Ozawa, Atsushi</creatorcontrib><creatorcontrib>Shibusawa, Nobuyuki</creatorcontrib><creatorcontrib>Satoh, Teturou</creatorcontrib><creatorcontrib>Yamada, Masanobu</creatorcontrib><creatorcontrib>Yamada, Shozo</creatorcontrib><creatorcontrib>Mori, Masatomo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashimoto, Koshi</au><au>Matsumoto, Shunichi</au><au>Ishida, Emi</au><au>Miura, Atsuko</au><au>Horiguchi, Kazuhiko</au><au>Ozawa, Atsushi</au><au>Shibusawa, Nobuyuki</au><au>Satoh, Teturou</au><au>Yamada, Masanobu</au><au>Yamada, Shozo</au><au>Mori, Masatomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2011-04-20</date><risdate>2011</risdate><volume>494</volume><issue>1</issue><spage>34</spage><epage>37</epage><pages>34-37</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>► LXR gene expression is not significantly different in pituitary adenomas. ► LXR-α/β ratio is significantly elevated in ACTH-secreting pituitary adenomas. ► LXR-β deteriorates POMC gene promoter activity in AtT-20 cells.
The liver X receptors (LXR-α and -β) are nuclear oxysterol receptors that play pivotal roles in regulating the expression of genes involved in cholesterol transport and metabolism. Recently, several groups have reported that the LXRs also regulate adrenal steroidogenesis. In the previous report, we demonstrated that LXR-α is dominantly expressed in the pituitary and that LXR-α positively regulates the proopiomelanocortin (POMC) gene promoter at the transcriptional level. In this report, we evaluated the expression levels of LXR-α and -β gene in the human pituitary tumor. Even though LXR-α mRNA levels are not significantly increased in ACTH-secreting adenomas, LXR-α/β expression ratio is significantly higher than other pituitary tumors including normal pituitaries. Furthermore, in At-T20 cells, which express POMC gene, overexpression of LXR-β decreased POMC gene promoter activities. Thus, we concluded that LXR-α/β gene expression ratio is a critical factor to activate POMC gene expression in ACTH-secreting pituitary adenomas.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21356276</pmid><doi>10.1016/j.neulet.2011.02.048</doi><tpages>4</tpages></addata></record> |
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| subjects | ACTH-secreting pituitary adenoma ACTH-Secreting Pituitary Adenoma - genetics ACTH-Secreting Pituitary Adenoma - metabolism Adenoma - genetics Adenoma - metabolism Adenoma - secretion Adrenocorticotropic Hormone - secretion Adult Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Human pituitary adenomas Humans Liver X receptor Liver X Receptors Male Middle Aged Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism POMC gene expression Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Vertebrates: nervous system and sense organs |
| title | Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas |
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