TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

Transient receptor potential melastatin-3 (TRPM3) is a broadly expressed Ca 2+-permeable nonselective cation channel. Previous work has demonstrated robust activation of TRPM3 by the neuroactive steroid pregnenolone sulfate (PS), but its in vivo gating mechanisms and functions remained poorly unders...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2011-05, Vol.70 (3), p.482-494
Hauptverfasser:	Vriens, Joris, Owsianik, Grzegorz, Hofmann, Thomas, Philipp, Stephan E., Stab, Julia, Chen, Xiaodi, Benoit, Melissa, Xue, Fenqin, Janssens, Annelies, Kerselaers, Sara, Oberwinkler, Johannes, Vennekens, Rudi, Gudermann, Thomas, Nilius, Bernd, Voets, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - therapeutic use Animals Behavior Behavior, Animal - drug effects Blood Glucose - drug effects Blood Glucose - genetics Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Calcium - metabolism Calcium Channel Blockers - pharmacology Capsaicin - pharmacology Cell Line, Transformed Cold Disease Models, Animal Dose-Response Relationship, Drug Freund's Adjuvant - adverse effects Ganglia, Spinal - cytology Gene Expression Regulation - genetics Gene Expression Regulation - radiation effects Heat Hot Temperature - adverse effects Humans Hyperalgesia - chemically induced Hyperalgesia - drug therapy Hyperalgesia - genetics Hyperalgesia - metabolism Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Membrane Potentials - drug effects Membrane Potentials - genetics Mice Mice, Inbred C57BL Mice, Knockout Mustard Plant Neurons Nifedipine - pharmacology Pain Measurement - drug effects Pain Measurement - methods Pain Threshold - drug effects Pain Threshold - physiology Patch-Clamp Techniques Plant Oils - pharmacology Pregnenolone - adverse effects Rodents Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism Telemetry - methods Time Factors Transfection - methods Transient Receptor Potential Channels - deficiency Transient Receptor Potential Channels - genetics Trigeminal Ganglion - cytology TRPA1 Cation Channel TRPM Cation Channels - antagonists & inhibitors TRPM Cation Channels - deficiency TRPM Cation Channels - genetics TRPM Cation Channels - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!