Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell–mediated skin inflammation
Background The diverse effects of histamine on immune regulation are a result of the differential expression and regulation of 4 histamine receptors. Many of the immediate allergic and inflammatory actions of histamine are mediated via the type 1 receptor (H1R). Objectives We hypothesized that H1R w...
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| creator | Vanbervliet, Béatrice, MSc Akdis, Mübeccel, MD Vocanson, Marc, PhD Rozières, Aurore, PhD Benetière, Josette, BSc Rouzaire, Paul, MSc Akdis, Cezmi A., MD, PhD Nicolas, Jean-François, MD, PhD Hennino, Ana, PhD |
| description | Background The diverse effects of histamine on immune regulation are a result of the differential expression and regulation of 4 histamine receptors. Many of the immediate allergic and inflammatory actions of histamine are mediated via the type 1 receptor (H1R). Objectives We hypothesized that H1R was involved in the fine-tuning of the initiation of T cell–mediated skin pathology—that is, dermatitis. Methods The impact of the H1R invalidation on the development of skin inflammation was analyzed in a mouse model of atopic dermatitis. Results We show that H1r– /– mice developed reduced allergen-specific skin lesions. Lack of H1R expression on dendritic cells (DCs) led to diminished IL-12, upregulated IL-23, and IL-6 production upon allergen stimulation. H1R engagement on dendritic cells was necessary for DC activation and subsequent priming of effector IFN-γ+ CD8+ T cells. We demonstrate here that H1R blockade on DCs promotes generation of noneffector IL-17+ CD8+ T cells that are unable to initiate the skin inflammation. Conclusion Our data identify that histamine signaling through the H1R on DCs is an important early event conditioning the quality of the skin effector immune response. |
| doi_str_mv | 10.1016/j.jaci.2010.12.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_872140149</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091674910018671</els_id><sourcerecordid>872140149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-f817deb3851d9afa8349b985535ab43d993372b464179cdec5b21a141c5cd2703</originalsourceid><addsrcrecordid>eNqFkkGOFCEUhonROO3oBVwYNsZV9fCAKorEmJjJjN1JRxeOa0IBNVJTRbVQbdI7V3MBj-I9PIQnkZpuNXGhKwL8_-Pxfw-hp0CWQKA665adNn5JyXxAl4TQe2gBRIqiqml5Hy0IkVBUgssT9CiljuQ9q-VDdEKBVrISbIFuVz5NevDB4eiM205jxCvAyV8H3ftwjceArQs2-skbbFzfJ7zt9T5hjW_cHsexd9gHPH10eH35tvj-7Wy9KUDgRvc6mLu7qzvfjy9fB2e9npzF6SYf-9D2ehj05MfwGD1odZ_ck-N6ij5cXlydr4rNuzfr89ebwnBBp6KtQVjXsLoEK3Wra8ZlI-uyZKVuOLNSMiZowysOQhrrTNlQ0MDBlMZSQdgpenGou43jp51Lkxp8mrvTwY27pGpBgRPg8v_KikAtQNCspAeliWNK0bVqG_2g414BUTMo1akZlJpBKaAqg8qmZ8fyuybH8tvyi0wWPD8KdDK6b2NO06c_Ok5kjmTWvTzoXI7ts3dRJeNdTt76DHRSdvT_7uPVX3aTsfv8YqbrUjfuYh6EpEClbFDv55GaJwpI_n4lgP0ETszGPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>860187172</pqid></control><display><type>article</type><title>Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell–mediated skin inflammation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Vanbervliet, Béatrice, MSc ; Akdis, Mübeccel, MD ; Vocanson, Marc, PhD ; Rozières, Aurore, PhD ; Benetière, Josette, BSc ; Rouzaire, Paul, MSc ; Akdis, Cezmi A., MD, PhD ; Nicolas, Jean-François, MD, PhD ; Hennino, Ana, PhD</creator><creatorcontrib>Vanbervliet, Béatrice, MSc ; Akdis, Mübeccel, MD ; Vocanson, Marc, PhD ; Rozières, Aurore, PhD ; Benetière, Josette, BSc ; Rouzaire, Paul, MSc ; Akdis, Cezmi A., MD, PhD ; Nicolas, Jean-François, MD, PhD ; Hennino, Ana, PhD</creatorcontrib><description>Background The diverse effects of histamine on immune regulation are a result of the differential expression and regulation of 4 histamine receptors. Many of the immediate allergic and inflammatory actions of histamine are mediated via the type 1 receptor (H1R). Objectives We hypothesized that H1R was involved in the fine-tuning of the initiation of T cell–mediated skin pathology—that is, dermatitis. Methods The impact of the H1R invalidation on the development of skin inflammation was analyzed in a mouse model of atopic dermatitis. Results We show that H1r– /– mice developed reduced allergen-specific skin lesions. Lack of H1R expression on dendritic cells (DCs) led to diminished IL-12, upregulated IL-23, and IL-6 production upon allergen stimulation. H1R engagement on dendritic cells was necessary for DC activation and subsequent priming of effector IFN-γ+ CD8+ T cells. We demonstrate here that H1R blockade on DCs promotes generation of noneffector IL-17+ CD8+ T cells that are unable to initiate the skin inflammation. Conclusion Our data identify that histamine signaling through the H1R on DCs is an important early event conditioning the quality of the skin effector immune response.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2010.12.002</identifier><identifier>PMID: 21269673</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Allergic diseases ; Allergy and Immunology ; Animals ; Atopic dermatitis ; Biological and medical sciences ; CD8 + T cell ; dendritic cell ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - metabolism ; Disease Models, Animal ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; H1R ; histamine ; Immunopathology ; Inflammation - immunology ; Inflammation - metabolism ; Interferon-gamma - immunology ; Interferon-gamma - metabolism ; Interleukin-17 - immunology ; Interleukin-17 - metabolism ; Lymphocyte Activation - immunology ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Histamine H1 - immunology ; Receptors, Histamine H1 - metabolism ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Signal Transduction - immunology ; Skin allergic diseases. Stinging insect allergies ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism</subject><ispartof>Journal of allergy and clinical immunology, 2011-04, Vol.127 (4), p.943-953.e10</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2011 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-f817deb3851d9afa8349b985535ab43d993372b464179cdec5b21a141c5cd2703</citedby><cites>FETCH-LOGICAL-c472t-f817deb3851d9afa8349b985535ab43d993372b464179cdec5b21a141c5cd2703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674910018671$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24094723$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21269673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanbervliet, Béatrice, MSc</creatorcontrib><creatorcontrib>Akdis, Mübeccel, MD</creatorcontrib><creatorcontrib>Vocanson, Marc, PhD</creatorcontrib><creatorcontrib>Rozières, Aurore, PhD</creatorcontrib><creatorcontrib>Benetière, Josette, BSc</creatorcontrib><creatorcontrib>Rouzaire, Paul, MSc</creatorcontrib><creatorcontrib>Akdis, Cezmi A., MD, PhD</creatorcontrib><creatorcontrib>Nicolas, Jean-François, MD, PhD</creatorcontrib><creatorcontrib>Hennino, Ana, PhD</creatorcontrib><title>Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell–mediated skin inflammation</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background The diverse effects of histamine on immune regulation are a result of the differential expression and regulation of 4 histamine receptors. Many of the immediate allergic and inflammatory actions of histamine are mediated via the type 1 receptor (H1R). Objectives We hypothesized that H1R was involved in the fine-tuning of the initiation of T cell–mediated skin pathology—that is, dermatitis. Methods The impact of the H1R invalidation on the development of skin inflammation was analyzed in a mouse model of atopic dermatitis. Results We show that H1r– /– mice developed reduced allergen-specific skin lesions. Lack of H1R expression on dendritic cells (DCs) led to diminished IL-12, upregulated IL-23, and IL-6 production upon allergen stimulation. H1R engagement on dendritic cells was necessary for DC activation and subsequent priming of effector IFN-γ+ CD8+ T cells. We demonstrate here that H1R blockade on DCs promotes generation of noneffector IL-17+ CD8+ T cells that are unable to initiate the skin inflammation. Conclusion Our data identify that histamine signaling through the H1R on DCs is an important early event conditioning the quality of the skin effector immune response.</description><subject>Allergic diseases</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>CD8 + T cell</subject><subject>dendritic cell</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - metabolism</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>H1R</subject><subject>histamine</subject><subject>Immunopathology</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Interferon-gamma - immunology</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukin-17 - immunology</subject><subject>Interleukin-17 - metabolism</subject><subject>Lymphocyte Activation - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Receptors, Histamine H1 - immunology</subject><subject>Receptors, Histamine H1 - metabolism</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Signal Transduction - immunology</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkGOFCEUhonROO3oBVwYNsZV9fCAKorEmJjJjN1JRxeOa0IBNVJTRbVQbdI7V3MBj-I9PIQnkZpuNXGhKwL8_-Pxfw-hp0CWQKA665adNn5JyXxAl4TQe2gBRIqiqml5Hy0IkVBUgssT9CiljuQ9q-VDdEKBVrISbIFuVz5NevDB4eiM205jxCvAyV8H3ftwjceArQs2-skbbFzfJ7zt9T5hjW_cHsexd9gHPH10eH35tvj-7Wy9KUDgRvc6mLu7qzvfjy9fB2e9npzF6SYf-9D2ehj05MfwGD1odZ_ck-N6ij5cXlydr4rNuzfr89ebwnBBp6KtQVjXsLoEK3Wra8ZlI-uyZKVuOLNSMiZowysOQhrrTNlQ0MDBlMZSQdgpenGou43jp51Lkxp8mrvTwY27pGpBgRPg8v_KikAtQNCspAeliWNK0bVqG_2g414BUTMo1akZlJpBKaAqg8qmZ8fyuybH8tvyi0wWPD8KdDK6b2NO06c_Ok5kjmTWvTzoXI7ts3dRJeNdTt76DHRSdvT_7uPVX3aTsfv8YqbrUjfuYh6EpEClbFDv55GaJwpI_n4lgP0ETszGPw</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Vanbervliet, Béatrice, MSc</creator><creator>Akdis, Mübeccel, MD</creator><creator>Vocanson, Marc, PhD</creator><creator>Rozières, Aurore, PhD</creator><creator>Benetière, Josette, BSc</creator><creator>Rouzaire, Paul, MSc</creator><creator>Akdis, Cezmi A., MD, PhD</creator><creator>Nicolas, Jean-François, MD, PhD</creator><creator>Hennino, Ana, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110401</creationdate><title>Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell–mediated skin inflammation</title><author>Vanbervliet, Béatrice, MSc ; Akdis, Mübeccel, MD ; Vocanson, Marc, PhD ; Rozières, Aurore, PhD ; Benetière, Josette, BSc ; Rouzaire, Paul, MSc ; Akdis, Cezmi A., MD, PhD ; Nicolas, Jean-François, MD, PhD ; Hennino, Ana, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-f817deb3851d9afa8349b985535ab43d993372b464179cdec5b21a141c5cd2703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Allergic diseases</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Atopic dermatitis</topic><topic>Biological and medical sciences</topic><topic>CD8 + T cell</topic><topic>dendritic cell</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatitis, Atopic - metabolism</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>H1R</topic><topic>histamine</topic><topic>Immunopathology</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Interferon-gamma - immunology</topic><topic>Interferon-gamma - metabolism</topic><topic>Interleukin-17 - immunology</topic><topic>Interleukin-17 - metabolism</topic><topic>Lymphocyte Activation - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Receptors, Histamine H1 - immunology</topic><topic>Receptors, Histamine H1 - metabolism</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Signal Transduction - immunology</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanbervliet, Béatrice, MSc</creatorcontrib><creatorcontrib>Akdis, Mübeccel, MD</creatorcontrib><creatorcontrib>Vocanson, Marc, PhD</creatorcontrib><creatorcontrib>Rozières, Aurore, PhD</creatorcontrib><creatorcontrib>Benetière, Josette, BSc</creatorcontrib><creatorcontrib>Rouzaire, Paul, MSc</creatorcontrib><creatorcontrib>Akdis, Cezmi A., MD, PhD</creatorcontrib><creatorcontrib>Nicolas, Jean-François, MD, PhD</creatorcontrib><creatorcontrib>Hennino, Ana, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanbervliet, Béatrice, MSc</au><au>Akdis, Mübeccel, MD</au><au>Vocanson, Marc, PhD</au><au>Rozières, Aurore, PhD</au><au>Benetière, Josette, BSc</au><au>Rouzaire, Paul, MSc</au><au>Akdis, Cezmi A., MD, PhD</au><au>Nicolas, Jean-François, MD, PhD</au><au>Hennino, Ana, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell–mediated skin inflammation</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>127</volume><issue>4</issue><spage>943</spage><epage>953.e10</epage><pages>943-953.e10</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background The diverse effects of histamine on immune regulation are a result of the differential expression and regulation of 4 histamine receptors. Many of the immediate allergic and inflammatory actions of histamine are mediated via the type 1 receptor (H1R). Objectives We hypothesized that H1R was involved in the fine-tuning of the initiation of T cell–mediated skin pathology—that is, dermatitis. Methods The impact of the H1R invalidation on the development of skin inflammation was analyzed in a mouse model of atopic dermatitis. Results We show that H1r– /– mice developed reduced allergen-specific skin lesions. Lack of H1R expression on dendritic cells (DCs) led to diminished IL-12, upregulated IL-23, and IL-6 production upon allergen stimulation. H1R engagement on dendritic cells was necessary for DC activation and subsequent priming of effector IFN-γ+ CD8+ T cells. We demonstrate here that H1R blockade on DCs promotes generation of noneffector IL-17+ CD8+ T cells that are unable to initiate the skin inflammation. Conclusion Our data identify that histamine signaling through the H1R on DCs is an important early event conditioning the quality of the skin effector immune response.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21269673</pmid><doi>10.1016/j.jaci.2010.12.002</doi><tpages>11</tpages></addata></record> |
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| subjects | Allergic diseases Allergy and Immunology Animals Atopic dermatitis Biological and medical sciences CD8 + T cell dendritic cell Dendritic Cells - immunology Dendritic Cells - metabolism Dermatitis, Atopic - immunology Dermatitis, Atopic - metabolism Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Fundamental immunology H1R histamine Immunopathology Inflammation - immunology Inflammation - metabolism Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-17 - immunology Interleukin-17 - metabolism Lymphocyte Activation - immunology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Receptors, Histamine H1 - immunology Receptors, Histamine H1 - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Signal Transduction - immunology Skin allergic diseases. Stinging insect allergies T-Lymphocytes - immunology T-Lymphocytes - metabolism |
| title | Histamine receptor H1 signaling on dendritic cells plays a key role in the IFN-γ/IL-17 balance in T cell–mediated skin inflammation |
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