Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors
Novel squalene synthase inhibitors are disclosed. SAR and pharmacological profile of selected compounds are discussed.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2011-04, Vol.21 (8), p.2554-2558 |
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| container_end_page | 2558 |
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| container_issue | 8 |
| container_start_page | 2554 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 21 |
| creator | Griebenow, Nils Flessner, Timo Buchmueller, Anja Raabe, Martin Bischoff, Hilmar Kolkhof, Peter |
| description | Novel squalene synthase inhibitors are disclosed. SAR and pharmacological profile of selected compounds are discussed. |
| doi_str_mv | 10.1016/j.bmcl.2011.02.004 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2554-2558 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_872139831 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | alkyl (aryl) transferases Animals Benzazepines - chemical synthesis Benzazepines - chemistry Benzazepines - pharmacokinetics Biological and medical sciences Crystallography, X-Ray enzyme inhibitors Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacokinetics Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors Farnesyl-Diphosphate Farnesyltransferase - metabolism General and cellular metabolism. Vitamins heterocyclic compounds Humans Medical sciences Mice Microsomes, Liver - metabolism Molecular Conformation Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship structure-activity relationships |
| title | Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors |
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