Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity

Background The antibody repertoires of allergic subjects are characterized by the presence of allergen-specific IgE antibodies. We have previously shown that the composition of the IgE repertoire is critical for allergen-mediated activation of human effector cells. Activation of CD4+ T cells in alle...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2011-04, Vol.127 (4), p.1029-1037
Hauptverfasser:	Holm, Jens, PhD, Willumsen, Nicholas, MSc, Würtzen, Peter A., PhD, Christensen, Lars H., PhD, Lund, Kaare, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	allergen Allergies Allergy Allergy and Immunology Antibodies, Blocking - immunology Antibody Affinity - immunology antibody clonality antibody repertoire antibody-binding affinity Antigen Presentation - immunology Antigens, Dermatophagoides - immunology Arthropod Proteins B-Lymphocytes - immunology Biological and medical sciences blocking IgG Cell Separation Early intervention Experiments facilitated antigen presentation Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune system Immunoassay Immunoglobulin E - immunology Immunoglobulin G - immunology Immunopathology Lymphocyte Activation - immunology Lymphocytes Medical sciences Receptors, IgE - immunology rIgE rIgG Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies T cell receptors T-cell activation T-Lymphocytes - immunology
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