Neurexin-Neuroligin Transsynaptic Interaction Mediates Learning-Related Synaptic Remodeling and Long-Term Facilitation in Aplysia

Neurexin and neuroligin, which undergo heterophilic interactions with each other at the synapse, are mutated in some patients with autism spectrum disorder, a set of disorders characterized by deficits in social and emotional learning. We have explored the role of neurexin and neuroligin at sensory-...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2011-05, Vol.70 (3), p.468-481
Hauptverfasser:	Choi, Yun-Beom, Li, Hsiu-Ling, Kassabov, Stefan R., Jin, Iksung, Puthanveettil, Sathyanarayanan V., Karl, Kevin A., Lu, Yang, Kim, Joung-Hun, Bailey, Craig H., Kandel, Eric R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Aplysia Arginine - genetics Autism Behavior Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cells, Cultured Central Nervous System - cytology Cloning, Molecular - methods Cysteine - genetics Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Green Fluorescent Proteins - genetics Humans Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Membrane Proteins - genetics Membrane Proteins - metabolism Microinjections - methods Molecular Sequence Data Motor Neurons - drug effects Motor Neurons - physiology Mutation - genetics Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neurons Oligodeoxyribonucleotides, Antisense - pharmacology Protein Binding - physiology Proteins Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Serotonin - pharmacology Studies Synapses - metabolism Synapses - physiology
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