A Randomized, Double-Blind Trial of Palonosetron Compared with Ondansetron in Preventing Postoperative Nausea and Vomiting after Gynaecological Laparoscopic Surgery
This randomized, double-blind study evaluated the relative efficacy of palonosetron (a new, selective 5-hydroxytryptamine type 3 [5-HT3] receptor antagonist) and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing gynaecological laparoscopic surgery. Patients re...
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| Veröffentlicht in: | Journal of international medical research 2011-04, Vol.39 (2), p.399-407 |
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| creator | Park, SK Cho, EJ |
| description | This randomized, double-blind study evaluated the relative efficacy of palonosetron (a new, selective 5-hydroxytryptamine type 3 [5-HT3] receptor antagonist) and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing gynaecological laparoscopic surgery. Patients received either palonosetron 0.075 mg (n = 45) or ondansetron 8 mg (n = 45), intravenously, immediately before induction of general anaesthesia. The occurrence of nausea and vomiting and the severity of nausea according to a visual analogue scale were monitored immediately after the end of surgery and during the following 24 h. The incidence of PONV was significantly lower in the palonosetron group compared with the ondansetron group (42.2% vs 66.7%, respectively). There were no significant statistical differences in the visual analogue scale for nausea. In conclusion, palonosetron 0.075 mg was more effective than ondansetron 8 mg in preventing PONV. |
| doi_str_mv | 10.1177/147323001103900207 |
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Patients received either palonosetron 0.075 mg (n = 45) or ondansetron 8 mg (n = 45), intravenously, immediately before induction of general anaesthesia. The occurrence of nausea and vomiting and the severity of nausea according to a visual analogue scale were monitored immediately after the end of surgery and during the following 24 h. The incidence of PONV was significantly lower in the palonosetron group compared with the ondansetron group (42.2% vs 66.7%, respectively). There were no significant statistical differences in the visual analogue scale for nausea. In conclusion, palonosetron 0.075 mg was more effective than ondansetron 8 mg in preventing PONV.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/147323001103900207</identifier><identifier>PMID: 21672343</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Anesthesia ; Antiemetics - administration & dosage ; Antiemetics - therapeutic use ; Demography ; Double-Blind Method ; Female ; Gynecologic Surgical Procedures - adverse effects ; Humans ; Incidence ; Injections, Intravenous ; Isoquinolines - administration & dosage ; Isoquinolines - therapeutic use ; Laparoscopy - adverse effects ; Ondansetron - administration & dosage ; Ondansetron - therapeutic use ; Patient Satisfaction ; Postoperative Nausea and Vomiting - drug therapy ; Postoperative Nausea and Vomiting - epidemiology ; Postoperative Nausea and Vomiting - prevention & control ; Quinuclidines - administration & dosage ; Quinuclidines - therapeutic use ; Treatment Outcome</subject><ispartof>Journal of international medical research, 2011-04, Vol.39 (2), p.399-407</ispartof><rights>2011 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a409t-d0d312be38944abfa692489800c4b9253c83ff9dd110e60f64bb48f7fe4304143</citedby><cites>FETCH-LOGICAL-a409t-d0d312be38944abfa692489800c4b9253c83ff9dd110e60f64bb48f7fe4304143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/147323001103900207$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/147323001103900207$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21947,27832,27903,27904,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/147323001103900207?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21672343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, SK</creatorcontrib><creatorcontrib>Cho, EJ</creatorcontrib><title>A Randomized, Double-Blind Trial of Palonosetron Compared with Ondansetron in Preventing Postoperative Nausea and Vomiting after Gynaecological Laparoscopic Surgery</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>This randomized, double-blind study evaluated the relative efficacy of palonosetron (a new, selective 5-hydroxytryptamine type 3 [5-HT3] receptor antagonist) and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing gynaecological laparoscopic surgery. Patients received either palonosetron 0.075 mg (n = 45) or ondansetron 8 mg (n = 45), intravenously, immediately before induction of general anaesthesia. The occurrence of nausea and vomiting and the severity of nausea according to a visual analogue scale were monitored immediately after the end of surgery and during the following 24 h. The incidence of PONV was significantly lower in the palonosetron group compared with the ondansetron group (42.2% vs 66.7%, respectively). There were no significant statistical differences in the visual analogue scale for nausea. In conclusion, palonosetron 0.075 mg was more effective than ondansetron 8 mg in preventing PONV.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Antiemetics - administration & dosage</subject><subject>Antiemetics - therapeutic use</subject><subject>Demography</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gynecologic Surgical Procedures - adverse effects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Injections, Intravenous</subject><subject>Isoquinolines - administration & dosage</subject><subject>Isoquinolines - therapeutic use</subject><subject>Laparoscopy - adverse effects</subject><subject>Ondansetron - administration & dosage</subject><subject>Ondansetron - therapeutic use</subject><subject>Patient Satisfaction</subject><subject>Postoperative Nausea and Vomiting - drug therapy</subject><subject>Postoperative Nausea and Vomiting - epidemiology</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Quinuclidines - administration & dosage</subject><subject>Quinuclidines - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhq0K1C6lf6AH5BsXQscf-Tq2CxSkFV1B6TVy4vHWVWIHOylafg8_FC-75YLEaaSZZ97XnpeQcwZvGSvLCyZLwQUAYyBqAA7lEVnsmtmu-4wsIJUMCshPyIsYHwAkL3J-TE44K0oupFiQX5f0i3LaD_Yn6jf0nZ_bHrOr3jpNb4NVPfWGrlXvnY84Be_o0g-jCqjpDzvd0xunlTtMrKPrgI_oJus2dO3j5EcMarKPSD-rOaKiyYreJbM_hDITBnq9dQo73_uN7ZLdSiV1Hzs_2o5-ncMGw_YleW5UH_HsUE_Jtw_vb5cfs9XN9afl5SpTEuop06AF4y2KqpZStUYVNZdVXQF0sq15LrpKGFNrnQ6GBZhCtq2sTGlQCpBMilPyeq87Bv99xjg1g40d9r1y6OfYVCVnIq9ySCTfk116awxomjHYQYVtw6DZhdP8G05aenWQn9sB9d-VpzQScLEHotpg8-Dn4NJ3_yf5G4Ecmb8</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Park, SK</creator><creator>Cho, EJ</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>A Randomized, Double-Blind Trial of Palonosetron Compared with Ondansetron in Preventing Postoperative Nausea and Vomiting after Gynaecological Laparoscopic Surgery</title><author>Park, SK ; Cho, EJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a409t-d0d312be38944abfa692489800c4b9253c83ff9dd110e60f64bb48f7fe4304143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Antiemetics - administration & dosage</topic><topic>Antiemetics - therapeutic use</topic><topic>Demography</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gynecologic Surgical Procedures - adverse effects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Injections, Intravenous</topic><topic>Isoquinolines - administration & dosage</topic><topic>Isoquinolines - therapeutic use</topic><topic>Laparoscopy - adverse effects</topic><topic>Ondansetron - administration & dosage</topic><topic>Ondansetron - therapeutic use</topic><topic>Patient Satisfaction</topic><topic>Postoperative Nausea and Vomiting - drug therapy</topic><topic>Postoperative Nausea and Vomiting - epidemiology</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Quinuclidines - administration & dosage</topic><topic>Quinuclidines - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, SK</creatorcontrib><creatorcontrib>Cho, EJ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Park, SK</au><au>Cho, EJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized, Double-Blind Trial of Palonosetron Compared with Ondansetron in Preventing Postoperative Nausea and Vomiting after Gynaecological Laparoscopic Surgery</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>39</volume><issue>2</issue><spage>399</spage><epage>407</epage><pages>399-407</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>This randomized, double-blind study evaluated the relative efficacy of palonosetron (a new, selective 5-hydroxytryptamine type 3 [5-HT3] receptor antagonist) and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing gynaecological laparoscopic surgery. Patients received either palonosetron 0.075 mg (n = 45) or ondansetron 8 mg (n = 45), intravenously, immediately before induction of general anaesthesia. The occurrence of nausea and vomiting and the severity of nausea according to a visual analogue scale were monitored immediately after the end of surgery and during the following 24 h. The incidence of PONV was significantly lower in the palonosetron group compared with the ondansetron group (42.2% vs 66.7%, respectively). There were no significant statistical differences in the visual analogue scale for nausea. In conclusion, palonosetron 0.075 mg was more effective than ondansetron 8 mg in preventing PONV.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21672343</pmid><doi>10.1177/147323001103900207</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Anesthesia Antiemetics - administration & dosage Antiemetics - therapeutic use Demography Double-Blind Method Female Gynecologic Surgical Procedures - adverse effects Humans Incidence Injections, Intravenous Isoquinolines - administration & dosage Isoquinolines - therapeutic use Laparoscopy - adverse effects Ondansetron - administration & dosage Ondansetron - therapeutic use Patient Satisfaction Postoperative Nausea and Vomiting - drug therapy Postoperative Nausea and Vomiting - epidemiology Postoperative Nausea and Vomiting - prevention & control Quinuclidines - administration & dosage Quinuclidines - therapeutic use Treatment Outcome |
| title | A Randomized, Double-Blind Trial of Palonosetron Compared with Ondansetron in Preventing Postoperative Nausea and Vomiting after Gynaecological Laparoscopic Surgery |
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