A Complex Double Deletion in LMNA Underlies Progressive Cardiac Conduction Disease, Atrial Arrhythmias, and Sudden Death

BACKGROUND—Cardiac conduction disease is a clinically and genetically heterogeneous disorder characterized by defects in electrical impulse generation and conduction and is associated with sudden cardiac death. METHODS AND RESULTS—We studied a 4-generation family with autosomal dominant progressive...

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Veröffentlicht in:	Circulation. Cardiovascular genetics 2011-06, Vol.4 (3), p.280-287
Hauptverfasser:	Marsman, Roos F, Bardai, Abdennasser, Postma, Alex V, Res, Jan C.J, Koopmann, Tamara T, Beekman, Leander, van der Wal, Allard C, Pinto, Yigal M, Lekanne Deprez, Ronald H, Wilde, Arthur A.M, Jordaens, Luc J, Bezzina, Connie R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arrhythmias, Cardiac - genetics Atrial Fibrillation - genetics Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Chromosome aberrations Classical genetics, quantitative genetics, hybrids Death, Sudden, Cardiac DNA Mutational Analysis Electrocardiography Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Fundamental and applied biological sciences. Psychology Gene Rearrangement Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Heart Heart Conduction System - physiopathology Human Humans Intensive care medicine Lamin Type A - genetics Male Medical genetics Medical sciences Middle Aged Mutation Myocardium - pathology Myocardium - ultrastructure Netherlands Pedigree Sequence Deletion Young Adult
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