Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight
We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM 2.5) on offspring birth weight. Among newborns from LISA cohort, we tested if polymorphisms of GSTT1, GSTP1, GSTM1, and CYP2D6 genes modified the effect measu...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2010-12, Vol.30 (4), p.600-612 |
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| creator | Slama, Rémy Gräbsch, Carolin Lepeule, Johanna Siroux, Valérie Cyrys, Josef Sausenthaler, Stefanie Herbarth, Olf Bauer, Mario Borte, Michael Wichmann, H. Erich Heinrich, Joachim |
| description | We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM
2.5) on offspring birth weight.
Among newborns from LISA cohort, we tested if polymorphisms of
GSTT1,
GSTP1,
GSTM1, and
CYP2D6 genes modified the effect measure of PM
2.5 on term birth weight. Subsequently, we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking).
PM
2.5 exposure above the median value (reference, below) was associated with birth weight changes by 76
g in the
homozygous wild type genotype (
n
=
161), −90
g in the
heterozygous genotype (
n
=
154) and −168
g in children with
GSTP1 *
1B/*
1B mutant genotype (
n
=
39, interaction test,
p
=
0.05). No effect measure modification with PM
2.5 was detected for
GSTT1,
GSTM1 or
CYP2D6 polymorphisms (
p
≥
0.12). No effect measure modification with
GSTP1 polymorphism was detected for active (
p
=
0.71) nor for passive smoking effects on birth weight (
p
=
0.13). |
| doi_str_mv | 10.1016/j.reprotox.2010.07.001 |
| format | Article |
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2.5) on offspring birth weight.
Among newborns from LISA cohort, we tested if polymorphisms of
GSTT1,
GSTP1,
GSTM1, and
CYP2D6 genes modified the effect measure of PM
2.5 on term birth weight. Subsequently, we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking).
PM
2.5 exposure above the median value (reference, below) was associated with birth weight changes by 76
g in the
homozygous wild type genotype (
n
=
161), −90
g in the
heterozygous genotype (
n
=
154) and −168
g in children with
GSTP1 *
1B/*
1B mutant genotype (
n
=
39, interaction test,
p
=
0.05). No effect measure modification with PM
2.5 was detected for
GSTT1,
GSTM1 or
CYP2D6 polymorphisms (
p
≥
0.12). No effect measure modification with
GSTP1 polymorphism was detected for active (
p
=
0.71) nor for passive smoking effects on birth weight (
p
=
0.13).</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2010.07.001</identifier><identifier>PMID: 20656020</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Air ; Air pollution ; Biological and medical sciences ; Birth weight ; Birth Weight - genetics ; Child ; Cohort Studies ; Cytochrome P-450 CYP2D6 - genetics ; Embryology: invertebrates and vertebrates. Teratology ; Environmental pollutants toxicology ; Female ; Fetal Growth Retardation - genetics ; Fundamental and applied biological sciences. Psychology ; Genetic ; Genetic Association Studies ; Germany ; Glutathione S-Transferase pi - genetics ; Glutathione Transferase - genetics ; Humans ; Inactivation, Metabolic - genetics ; Maternal Exposure - adverse effects ; Medical sciences ; Mutation ; Particulate matter ; Particulate Matter - toxicity ; Passive smoking ; Polymorphism ; Polymorphism, Genetic ; Smoking ; Smoking - adverse effects ; Teratology. Teratogens ; Tobacco, tobacco smoking ; Toxicology ; Vehicle Emissions ; Young Adult</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2010-12, Vol.30 (4), p.600-612</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-4d64aa68cf4a9eecc0a11bbb14ed59de3e3248ec3289777b381aaaaf992874b63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.reprotox.2010.07.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23699596$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20656020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slama, Rémy</creatorcontrib><creatorcontrib>Gräbsch, Carolin</creatorcontrib><creatorcontrib>Lepeule, Johanna</creatorcontrib><creatorcontrib>Siroux, Valérie</creatorcontrib><creatorcontrib>Cyrys, Josef</creatorcontrib><creatorcontrib>Sausenthaler, Stefanie</creatorcontrib><creatorcontrib>Herbarth, Olf</creatorcontrib><creatorcontrib>Bauer, Mario</creatorcontrib><creatorcontrib>Borte, Michael</creatorcontrib><creatorcontrib>Wichmann, H. Erich</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><title>Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM
2.5) on offspring birth weight.
Among newborns from LISA cohort, we tested if polymorphisms of
GSTT1,
GSTP1,
GSTM1, and
CYP2D6 genes modified the effect measure of PM
2.5 on term birth weight. Subsequently, we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking).
PM
2.5 exposure above the median value (reference, below) was associated with birth weight changes by 76
g in the
homozygous wild type genotype (
n
=
161), −90
g in the
heterozygous genotype (
n
=
154) and −168
g in children with
GSTP1 *
1B/*
1B mutant genotype (
n
=
39, interaction test,
p
=
0.05). No effect measure modification with PM
2.5 was detected for
GSTT1,
GSTM1 or
CYP2D6 polymorphisms (
p
≥
0.12). No effect measure modification with
GSTP1 polymorphism was detected for active (
p
=
0.71) nor for passive smoking effects on birth weight (
p
=
0.13).</description><subject>Adult</subject><subject>Air</subject><subject>Air pollution</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Birth Weight - genetics</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Cytochrome P-450 CYP2D6 - genetics</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Environmental pollutants toxicology</subject><subject>Female</subject><subject>Fetal Growth Retardation - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic</subject><subject>Genetic Association Studies</subject><subject>Germany</subject><subject>Glutathione S-Transferase pi - genetics</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Inactivation, Metabolic - genetics</subject><subject>Maternal Exposure - adverse effects</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Particulate matter</subject><subject>Particulate Matter - toxicity</subject><subject>Passive smoking</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Teratology. Teratogens</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Vehicle Emissions</subject><subject>Young Adult</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhSMEotPCX6i8QWzI4Efixw5UQUEqYgNry3FuZjxK7GA7Zcqvx9FMYVlvLB1_597re6rqmuAtwYS_P2wjzDHkcNxSXEQsthiTZ9WGSMFqIrB8Xm2wVLjmlMmL6jKlA8a4EUq8rC4o5i3HFG-q9M1kiN6MaHAe0GxidnYZi4gmk8sTguMc0hLhHZrD-DCFOO9dmpDz6Ag-dC4UQz1BNl0Y3R_nd2gHHhIyvkdhGNIcV61zMe_Rb3C7fX5VvRjMmOD1-b6qfn7-9OPmS333_fbrzce72rYNy3XT88YYLu3QGAVgLTaEdF1HGuhb1QMDRhsJllGphBAdk8SUMyhFpWg6zq6qt6e6ZVG_FkhZTy5ZGEfjISxJS0EJVZzRp0nSto1q27UmP5E2hpQiDLr8bzLxQROs12T0QT8mo9dkNBa6JFOM1-cWSzdB_8_2GEUB3pwBk6wZh2i8dek_x7hSrVon-HDioKzu3kHUyTrwFnoXwWbdB_fULH8Bry2zgA</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Slama, Rémy</creator><creator>Gräbsch, Carolin</creator><creator>Lepeule, Johanna</creator><creator>Siroux, Valérie</creator><creator>Cyrys, Josef</creator><creator>Sausenthaler, Stefanie</creator><creator>Herbarth, Olf</creator><creator>Bauer, Mario</creator><creator>Borte, Michael</creator><creator>Wichmann, H. Erich</creator><creator>Heinrich, Joachim</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20101201</creationdate><title>Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight</title><author>Slama, Rémy ; Gräbsch, Carolin ; Lepeule, Johanna ; Siroux, Valérie ; Cyrys, Josef ; Sausenthaler, Stefanie ; Herbarth, Olf ; Bauer, Mario ; Borte, Michael ; Wichmann, H. Erich ; Heinrich, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-4d64aa68cf4a9eecc0a11bbb14ed59de3e3248ec3289777b381aaaaf992874b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Air</topic><topic>Air pollution</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Birth Weight - genetics</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Cytochrome P-450 CYP2D6 - genetics</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Environmental pollutants toxicology</topic><topic>Female</topic><topic>Fetal Growth Retardation - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic</topic><topic>Genetic Association Studies</topic><topic>Germany</topic><topic>Glutathione S-Transferase pi - genetics</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Inactivation, Metabolic - genetics</topic><topic>Maternal Exposure - adverse effects</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Particulate matter</topic><topic>Particulate Matter - toxicity</topic><topic>Passive smoking</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Teratology. Teratogens</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Vehicle Emissions</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slama, Rémy</creatorcontrib><creatorcontrib>Gräbsch, Carolin</creatorcontrib><creatorcontrib>Lepeule, Johanna</creatorcontrib><creatorcontrib>Siroux, Valérie</creatorcontrib><creatorcontrib>Cyrys, Josef</creatorcontrib><creatorcontrib>Sausenthaler, Stefanie</creatorcontrib><creatorcontrib>Herbarth, Olf</creatorcontrib><creatorcontrib>Bauer, Mario</creatorcontrib><creatorcontrib>Borte, Michael</creatorcontrib><creatorcontrib>Wichmann, H. Erich</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slama, Rémy</au><au>Gräbsch, Carolin</au><au>Lepeule, Johanna</au><au>Siroux, Valérie</au><au>Cyrys, Josef</au><au>Sausenthaler, Stefanie</au><au>Herbarth, Olf</au><au>Bauer, Mario</au><au>Borte, Michael</au><au>Wichmann, H. Erich</au><au>Heinrich, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>30</volume><issue>4</issue><spage>600</spage><epage>612</epage><pages>600-612</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM
2.5) on offspring birth weight.
Among newborns from LISA cohort, we tested if polymorphisms of
GSTT1,
GSTP1,
GSTM1, and
CYP2D6 genes modified the effect measure of PM
2.5 on term birth weight. Subsequently, we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking).
PM
2.5 exposure above the median value (reference, below) was associated with birth weight changes by 76
g in the
homozygous wild type genotype (
n
=
161), −90
g in the
heterozygous genotype (
n
=
154) and −168
g in children with
GSTP1 *
1B/*
1B mutant genotype (
n
=
39, interaction test,
p
=
0.05). No effect measure modification with PM
2.5 was detected for
GSTT1,
GSTM1 or
CYP2D6 polymorphisms (
p
≥
0.12). No effect measure modification with
GSTP1 polymorphism was detected for active (
p
=
0.71) nor for passive smoking effects on birth weight (
p
=
0.13).</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20656020</pmid><doi>10.1016/j.reprotox.2010.07.001</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-6238 |
| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2010-12, Vol.30 (4), p.600-612 |
| issn | 0890-6238 1873-1708 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_872129632 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Air Air pollution Biological and medical sciences Birth weight Birth Weight - genetics Child Cohort Studies Cytochrome P-450 CYP2D6 - genetics Embryology: invertebrates and vertebrates. Teratology Environmental pollutants toxicology Female Fetal Growth Retardation - genetics Fundamental and applied biological sciences. Psychology Genetic Genetic Association Studies Germany Glutathione S-Transferase pi - genetics Glutathione Transferase - genetics Humans Inactivation, Metabolic - genetics Maternal Exposure - adverse effects Medical sciences Mutation Particulate matter Particulate Matter - toxicity Passive smoking Polymorphism Polymorphism, Genetic Smoking Smoking - adverse effects Teratology. Teratogens Tobacco, tobacco smoking Toxicology Vehicle Emissions Young Adult |
| title | Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight |
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