Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern

To investigate the efficacy of long‐term lamivudine (3TC) and adefovir dipivoxil (ADV) combination therapy in 3TC‐resistant chronic hepatitis B virus (HBV) infected patients, we analysed 28 3TC‐resistant patients treated with the combination therapy during 47 months (range, 9–75). At 12, 24, 36, and...

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Veröffentlicht in:	Journal of viral hepatitis 2011-03, Vol.18 (3), p.206-215
Hauptverfasser:	Inoue, J., Ueno, Y., Wakui, Y., Niitsuma, H., Fukushima, K., Yamagiwa, Y., Shiina, M., Kondo, Y., Kakazu, E., Tamai, K., Obara, N., Iwasaki, T., Shimosegawa, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adefovir Adenine - administration & dosage Adenine - analogs & derivatives Adolescent Adult Aged chronic hepatitis B Disease resistance DNA, Viral - chemistry DNA, Viral - genetics drug resistance Drug Resistance, Viral - genetics Drug Therapy, Combination Female Genotype Genotypes HBV Hepatitis B Hepatitis B virus Hepatitis B virus - genetics Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - enzymology Hepatitis B, Chronic - genetics Hepatitis B, Chronic - virology Humans Inhibitory Concentration 50 Kaplan-Meier Estimate Lamivudine Lamivudine - administration & dosage Longitudinal Studies Male Middle Aged Mutation Organophosphonates - administration & dosage Point Mutation Polymerase Chain Reaction Reverse Transcriptase Inhibitors - administration & dosage RNA-Directed DNA Polymerase - genetics rtA200V Sequence Analysis, DNA Young Adult
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