Genomic and metabolomic patterns segregate with responses to calcium and vitamin D supplementation

Inter-individual response differences to vitamin D and Ca supplementation may be under genetic control through vitamin D and oestrogen receptor genes, which may influence their absorption and/or metabolism. Metabolomic studies on blood and urine from subjects supplemented with Ca and vitamin D revea...

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Veröffentlicht in:	British journal of nutrition 2011-01, Vol.105 (1), p.71-79
Hauptverfasser:	Elnenaei, Manal O., Chandra, Rama, Mangion, Tina, Moniz, Caje
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Bone density Bone Density - genetics Bone Density - physiology Calcium Calcium, Dietary - administration & dosage Calcium, Dietary - metabolism Case-Control Studies Dietary Supplements Estrogen Receptor alpha - genetics Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Genome Genomics Genotype Human and Clinical Nutrition Humans Intestinal Absorption Magnetic Resonance Spectroscopy Metabolism Metabolites Metabolome Middle Aged Nutrition research Osteoporosis, Postmenopausal - genetics Osteoporosis, Postmenopausal - metabolism Osteoporosis, Postmenopausal - pathology Pattern recognition Pharmacogenetics Polymorphism, Genetic Prospective Studies Receptors, Calcitriol - genetics Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - administration & dosage Vitamin D - genetics Vitamin D - metabolism
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