Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein- and energy-dense nutritional supplement containing eicosapentaenoic acid
Background Cancer‐associated weight loss may be mediated by an inflammatory response to cancer. Eicosapentaenoic acid (EPA) may suppress this response. Methods Beginning no later than 2 weeks before surgery, patients with head and neck cancer and with weight loss, who were undergoing major resection...
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| Veröffentlicht in: | Head & neck 2011-07, Vol.33 (7), p.1027-1033 |
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| creator | Weed, Harrison G. Ferguson, Maree L. Gaff, Robin L Hustead, Deborah S. Nelson, Jeffrey L. Voss, Anne C. |
| description | Background
Cancer‐associated weight loss may be mediated by an inflammatory response to cancer. Eicosapentaenoic acid (EPA) may suppress this response.
Methods
Beginning no later than 2 weeks before surgery, patients with head and neck cancer and with weight loss, who were undergoing major resection with curative intent consumed a protein‐ and energy‐dense nutritional supplement containing EPA from fish oil, in addition to usual diet or tube feed.
Results
Thirty‐one subjects consumed an average of 1.8 containers/day before surgery and 1.5/day during hospitalization (per container: 300 kilocalories, 16 grams (g) protein, 1.08 g EPA). Seventy percent of subjects maintained or gained weight before hospital admission. Mean weight gain was 0.71 kg at admission and 0.66 kg at discharge. At discharge lean body mass increased by 3.20 kg (p < .001) and fat decreased by 3.19 kg (p < .001).
Conclusions
An EPA‐containing protein‐ and energy‐dense nutritional supplement may help increase perioperative lean body mass in patients with head and neck cancer–related weight loss. © 2010 Wiley Periodicals, Inc. Head Neck, 2011 |
| doi_str_mv | 10.1002/hed.21580 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_872124897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>872124897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3920-346bd8c91bbed7574ffaefa55c3945f7aeff5003ab3d4dde9f49157d0d33ab0a3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhiMEoqVw4A8gXxDikNaJnTg50m-kFUgIVImLNbEnu6aJk9oObf5Zfx7eZhdOSJY_xs87Y8-bJG8zepxRmp9sUB_nWVHRZ8lhRmuRUsbF8-2es5RRwQ-SV97_opSykucvk4Oc1qWoyuoweVwhWNIMeiY9eE_WYCyJY4Rg0AZP7k3YkA2CJmA1sahuib-boB8mTxR2HVFgFToSHEJATUZ0ZohT1P_Gbl70QEY3BDQ2fcqCFt16TjVaj8ROwZlgBgsd8dM4dtjHwkQNNsS3GLsmaNTgYYxRQDsYRUAZ_Tp50ULn8c1uPUp-XF58P7tOV1-vPp99WqWK1TlNGS8bXak6axrUohC8bQFbKIp4zYtWxENbxL5AwzTXGuuW11khNNUsxiiwo-TDkjf-4G5CH2Rv_PbjYDH2QFYiz3Je1SKSHxdSucF7h60cnenBzTKjcuuTjD7JJ58i-26XdWr6GN2Te2Mi8H4HgFfQtS522fh_HM8rWtZb7mTh7k2H8_8ryuuL833pdFEYH_DhrwLcrSwFE4W8-XIlz1eXp6tvpz_lDfsDd1--kg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>872124897</pqid></control><display><type>article</type><title>Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein- and energy-dense nutritional supplement containing eicosapentaenoic acid</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Weed, Harrison G. ; Ferguson, Maree L. ; Gaff, Robin L ; Hustead, Deborah S. ; Nelson, Jeffrey L. ; Voss, Anne C.</creator><creatorcontrib>Weed, Harrison G. ; Ferguson, Maree L. ; Gaff, Robin L ; Hustead, Deborah S. ; Nelson, Jeffrey L. ; Voss, Anne C.</creatorcontrib><description>Background
Cancer‐associated weight loss may be mediated by an inflammatory response to cancer. Eicosapentaenoic acid (EPA) may suppress this response.
Methods
Beginning no later than 2 weeks before surgery, patients with head and neck cancer and with weight loss, who were undergoing major resection with curative intent consumed a protein‐ and energy‐dense nutritional supplement containing EPA from fish oil, in addition to usual diet or tube feed.
Results
Thirty‐one subjects consumed an average of 1.8 containers/day before surgery and 1.5/day during hospitalization (per container: 300 kilocalories, 16 grams (g) protein, 1.08 g EPA). Seventy percent of subjects maintained or gained weight before hospital admission. Mean weight gain was 0.71 kg at admission and 0.66 kg at discharge. At discharge lean body mass increased by 3.20 kg (p < .001) and fat decreased by 3.19 kg (p < .001).
Conclusions
An EPA‐containing protein‐ and energy‐dense nutritional supplement may help increase perioperative lean body mass in patients with head and neck cancer–related weight loss. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21580</identifier><identifier>PMID: 20967868</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Body Composition ; cachexia ; Cachexia - diet therapy ; Carcinoma, Squamous Cell - diet therapy ; Carcinoma, Squamous Cell - surgery ; Combined Modality Therapy ; Dietary Proteins - administration & dosage ; Dietary Supplements ; eicosanoids ; Eicosapentaenoic Acid - pharmacology ; Eicosapentaenoic Acid - therapeutic use ; Female ; fish oils ; head and neck neoplasms ; Head and Neck Neoplasms - diet therapy ; Head and Neck Neoplasms - surgery ; Humans ; Male ; Medical sciences ; Middle Aged ; Otorhinolaryngology. Stomatology ; Prospective Studies ; squamous cell cancer ; Squamous Cell Carcinoma of Head and Neck ; Weight Loss - drug effects</subject><ispartof>Head & neck, 2011-07, Vol.33 (7), p.1027-1033</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3920-346bd8c91bbed7574ffaefa55c3945f7aeff5003ab3d4dde9f49157d0d33ab0a3</citedby><cites>FETCH-LOGICAL-c3920-346bd8c91bbed7574ffaefa55c3945f7aeff5003ab3d4dde9f49157d0d33ab0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21580$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21580$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24280698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20967868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weed, Harrison G.</creatorcontrib><creatorcontrib>Ferguson, Maree L.</creatorcontrib><creatorcontrib>Gaff, Robin L</creatorcontrib><creatorcontrib>Hustead, Deborah S.</creatorcontrib><creatorcontrib>Nelson, Jeffrey L.</creatorcontrib><creatorcontrib>Voss, Anne C.</creatorcontrib><title>Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein- and energy-dense nutritional supplement containing eicosapentaenoic acid</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Cancer‐associated weight loss may be mediated by an inflammatory response to cancer. Eicosapentaenoic acid (EPA) may suppress this response.
Methods
Beginning no later than 2 weeks before surgery, patients with head and neck cancer and with weight loss, who were undergoing major resection with curative intent consumed a protein‐ and energy‐dense nutritional supplement containing EPA from fish oil, in addition to usual diet or tube feed.
Results
Thirty‐one subjects consumed an average of 1.8 containers/day before surgery and 1.5/day during hospitalization (per container: 300 kilocalories, 16 grams (g) protein, 1.08 g EPA). Seventy percent of subjects maintained or gained weight before hospital admission. Mean weight gain was 0.71 kg at admission and 0.66 kg at discharge. At discharge lean body mass increased by 3.20 kg (p < .001) and fat decreased by 3.19 kg (p < .001).
Conclusions
An EPA‐containing protein‐ and energy‐dense nutritional supplement may help increase perioperative lean body mass in patients with head and neck cancer–related weight loss. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>cachexia</subject><subject>Cachexia - diet therapy</subject><subject>Carcinoma, Squamous Cell - diet therapy</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Combined Modality Therapy</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Supplements</subject><subject>eicosanoids</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Eicosapentaenoic Acid - therapeutic use</subject><subject>Female</subject><subject>fish oils</subject><subject>head and neck neoplasms</subject><subject>Head and Neck Neoplasms - diet therapy</subject><subject>Head and Neck Neoplasms - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prospective Studies</subject><subject>squamous cell cancer</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Weight Loss - drug effects</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhiMEoqVw4A8gXxDikNaJnTg50m-kFUgIVImLNbEnu6aJk9oObf5Zfx7eZhdOSJY_xs87Y8-bJG8zepxRmp9sUB_nWVHRZ8lhRmuRUsbF8-2es5RRwQ-SV97_opSykucvk4Oc1qWoyuoweVwhWNIMeiY9eE_WYCyJY4Rg0AZP7k3YkA2CJmA1sahuib-boB8mTxR2HVFgFToSHEJATUZ0ZohT1P_Gbl70QEY3BDQ2fcqCFt16TjVaj8ROwZlgBgsd8dM4dtjHwkQNNsS3GLsmaNTgYYxRQDsYRUAZ_Tp50ULn8c1uPUp-XF58P7tOV1-vPp99WqWK1TlNGS8bXak6axrUohC8bQFbKIp4zYtWxENbxL5AwzTXGuuW11khNNUsxiiwo-TDkjf-4G5CH2Rv_PbjYDH2QFYiz3Je1SKSHxdSucF7h60cnenBzTKjcuuTjD7JJ58i-26XdWr6GN2Te2Mi8H4HgFfQtS522fh_HM8rWtZb7mTh7k2H8_8ryuuL833pdFEYH_DhrwLcrSwFE4W8-XIlz1eXp6tvpz_lDfsDd1--kg</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Weed, Harrison G.</creator><creator>Ferguson, Maree L.</creator><creator>Gaff, Robin L</creator><creator>Hustead, Deborah S.</creator><creator>Nelson, Jeffrey L.</creator><creator>Voss, Anne C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201107</creationdate><title>Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein- and energy-dense nutritional supplement containing eicosapentaenoic acid</title><author>Weed, Harrison G. ; Ferguson, Maree L. ; Gaff, Robin L ; Hustead, Deborah S. ; Nelson, Jeffrey L. ; Voss, Anne C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3920-346bd8c91bbed7574ffaefa55c3945f7aeff5003ab3d4dde9f49157d0d33ab0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>cachexia</topic><topic>Cachexia - diet therapy</topic><topic>Carcinoma, Squamous Cell - diet therapy</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Combined Modality Therapy</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Supplements</topic><topic>eicosanoids</topic><topic>Eicosapentaenoic Acid - pharmacology</topic><topic>Eicosapentaenoic Acid - therapeutic use</topic><topic>Female</topic><topic>fish oils</topic><topic>head and neck neoplasms</topic><topic>Head and Neck Neoplasms - diet therapy</topic><topic>Head and Neck Neoplasms - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prospective Studies</topic><topic>squamous cell cancer</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weed, Harrison G.</creatorcontrib><creatorcontrib>Ferguson, Maree L.</creatorcontrib><creatorcontrib>Gaff, Robin L</creatorcontrib><creatorcontrib>Hustead, Deborah S.</creatorcontrib><creatorcontrib>Nelson, Jeffrey L.</creatorcontrib><creatorcontrib>Voss, Anne C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weed, Harrison G.</au><au>Ferguson, Maree L.</au><au>Gaff, Robin L</au><au>Hustead, Deborah S.</au><au>Nelson, Jeffrey L.</au><au>Voss, Anne C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein- and energy-dense nutritional supplement containing eicosapentaenoic acid</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2011-07</date><risdate>2011</risdate><volume>33</volume><issue>7</issue><spage>1027</spage><epage>1033</epage><pages>1027-1033</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Cancer‐associated weight loss may be mediated by an inflammatory response to cancer. Eicosapentaenoic acid (EPA) may suppress this response.
Methods
Beginning no later than 2 weeks before surgery, patients with head and neck cancer and with weight loss, who were undergoing major resection with curative intent consumed a protein‐ and energy‐dense nutritional supplement containing EPA from fish oil, in addition to usual diet or tube feed.
Results
Thirty‐one subjects consumed an average of 1.8 containers/day before surgery and 1.5/day during hospitalization (per container: 300 kilocalories, 16 grams (g) protein, 1.08 g EPA). Seventy percent of subjects maintained or gained weight before hospital admission. Mean weight gain was 0.71 kg at admission and 0.66 kg at discharge. At discharge lean body mass increased by 3.20 kg (p < .001) and fat decreased by 3.19 kg (p < .001).
Conclusions
An EPA‐containing protein‐ and energy‐dense nutritional supplement may help increase perioperative lean body mass in patients with head and neck cancer–related weight loss. © 2010 Wiley Periodicals, Inc. Head Neck, 2011</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20967868</pmid><doi>10.1002/hed.21580</doi><tpages>7</tpages></addata></record> |
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| issn | 1043-3074 1097-0347 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Biological and medical sciences Body Composition cachexia Cachexia - diet therapy Carcinoma, Squamous Cell - diet therapy Carcinoma, Squamous Cell - surgery Combined Modality Therapy Dietary Proteins - administration & dosage Dietary Supplements eicosanoids Eicosapentaenoic Acid - pharmacology Eicosapentaenoic Acid - therapeutic use Female fish oils head and neck neoplasms Head and Neck Neoplasms - diet therapy Head and Neck Neoplasms - surgery Humans Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology Prospective Studies squamous cell cancer Squamous Cell Carcinoma of Head and Neck Weight Loss - drug effects |
| title | Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein- and energy-dense nutritional supplement containing eicosapentaenoic acid |
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