Genotypic and phenotypic characterisation of invasive Streptococcus pneumoniae isolates from Hungary, and coverage of the conjugate vaccines
Background and aimsThe 7-valent conjugate pneumococcal vaccine (Prevenar) was introduced as a recommended (but not yet obligatory) vaccine in Hungary in April 2009 and there was a sharp increase in the number of children vaccinated. Hence there is an urgent need for in-depth epidemiological data on...
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| Veröffentlicht in: | Journal of clinical pathology 2010-12, Vol.63 (12), p.1116-1120 |
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| creator | Dobay, Orsolya Ungvári, Ágnes Kardos, Szilvia Kristóf, Katalin Hajdú, Edit Szabó, Judit Knausz, Márta Nagy, Erzsébet Rozgonyi, Ferenc Amyes, Sebastian G B Nagy, Károly |
| description | Background and aimsThe 7-valent conjugate pneumococcal vaccine (Prevenar) was introduced as a recommended (but not yet obligatory) vaccine in Hungary in April 2009 and there was a sharp increase in the number of children vaccinated. Hence there is an urgent need for in-depth epidemiological data on invasive pneumococci before vaccination becomes widespread. Such a study has never been done before in Hungary.Methods144 pneumococcal isolates, obtained from invasive infections or pneumonia, were collected from eight Hungarian diagnostic laboratories between 2000 and 2008. After confirmation of species identity, their susceptibilities to nine antibiotics were determined by Etest and agar dilution method. The serotypes and pulsed-field gel electrophoresis genotypes of the strains were also determined.ResultsIn this cohort, most of the isolates were from patients at the extreme of life. Only 1.4% of the strains were resistant to penicillin, but nearly 40% were resistant to erythromycin (mainly due to erm(B) gene). Higher incidences of resistance were found in the very young and very old. The most prevalent serotypes in the cohort in descending order were 14, 6A, 6, 6B, 23F, 3, 19F and 11A.ConclusionsResults showed a similar but not identical profile to previously examined strains causing pulmonary infections in Hungary. The serotypes could be correlated to patient groups. Furthermore, there were examples of serotype switching in strains showing identical genotype but different serotype. The study also shows a good coverage by the conjugate vaccines over the invasive pneumococcal strains in Hungary based on the detected serotypes. |
| doi_str_mv | 10.1136/jcp.2010.079780 |
| format | Article |
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Hence there is an urgent need for in-depth epidemiological data on invasive pneumococci before vaccination becomes widespread. Such a study has never been done before in Hungary.Methods144 pneumococcal isolates, obtained from invasive infections or pneumonia, were collected from eight Hungarian diagnostic laboratories between 2000 and 2008. After confirmation of species identity, their susceptibilities to nine antibiotics were determined by Etest and agar dilution method. The serotypes and pulsed-field gel electrophoresis genotypes of the strains were also determined.ResultsIn this cohort, most of the isolates were from patients at the extreme of life. Only 1.4% of the strains were resistant to penicillin, but nearly 40% were resistant to erythromycin (mainly due to erm(B) gene). Higher incidences of resistance were found in the very young and very old. The most prevalent serotypes in the cohort in descending order were 14, 6A, 6, 6B, 23F, 3, 19F and 11A.ConclusionsResults showed a similar but not identical profile to previously examined strains causing pulmonary infections in Hungary. The serotypes could be correlated to patient groups. Furthermore, there were examples of serotype switching in strains showing identical genotype but different serotype. The study also shows a good coverage by the conjugate vaccines over the invasive pneumococcal strains in Hungary based on the detected serotypes.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2010.079780</identifier><identifier>PMID: 20943819</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Child, Preschool ; Drug Resistance, Bacterial ; Electrophoresis, Gel, Pulsed-Field ; Female ; Genotype ; Heptavalent Pneumococcal Conjugate Vaccine ; Humans ; Hungary - epidemiology ; Infant ; Infant, Newborn ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Microbial Sensitivity Tests - methods ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Phenotype ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines - administration & dosage ; Retrospective Studies ; Serotyping - methods ; Streptococcus pneumoniae ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - drug effects ; Streptococcus pneumoniae - genetics ; Streptococcus pneumoniae - isolation & purification ; Vaccines, Conjugate - administration & dosage ; Young Adult</subject><ispartof>Journal of clinical pathology, 2010-12, Vol.63 (12), p.1116-1120</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b459t-b9dc18094044e2b227c4ae216ffbf4d37c26e984baf0054b0c31a024648d9ee3</citedby><cites>FETCH-LOGICAL-b459t-b9dc18094044e2b227c4ae216ffbf4d37c26e984baf0054b0c31a024648d9ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jcp.bmj.com/content/63/12/1116.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jcp.bmj.com/content/63/12/1116.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23531332$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20943819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dobay, Orsolya</creatorcontrib><creatorcontrib>Ungvári, Ágnes</creatorcontrib><creatorcontrib>Kardos, Szilvia</creatorcontrib><creatorcontrib>Kristóf, Katalin</creatorcontrib><creatorcontrib>Hajdú, Edit</creatorcontrib><creatorcontrib>Szabó, Judit</creatorcontrib><creatorcontrib>Knausz, Márta</creatorcontrib><creatorcontrib>Nagy, Erzsébet</creatorcontrib><creatorcontrib>Rozgonyi, Ferenc</creatorcontrib><creatorcontrib>Amyes, Sebastian G B</creatorcontrib><creatorcontrib>Nagy, Károly</creatorcontrib><title>Genotypic and phenotypic characterisation of invasive Streptococcus pneumoniae isolates from Hungary, and coverage of the conjugate vaccines</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Background and aimsThe 7-valent conjugate pneumococcal vaccine (Prevenar) was introduced as a recommended (but not yet obligatory) vaccine in Hungary in April 2009 and there was a sharp increase in the number of children vaccinated. Hence there is an urgent need for in-depth epidemiological data on invasive pneumococci before vaccination becomes widespread. Such a study has never been done before in Hungary.Methods144 pneumococcal isolates, obtained from invasive infections or pneumonia, were collected from eight Hungarian diagnostic laboratories between 2000 and 2008. After confirmation of species identity, their susceptibilities to nine antibiotics were determined by Etest and agar dilution method. The serotypes and pulsed-field gel electrophoresis genotypes of the strains were also determined.ResultsIn this cohort, most of the isolates were from patients at the extreme of life. Only 1.4% of the strains were resistant to penicillin, but nearly 40% were resistant to erythromycin (mainly due to erm(B) gene). Higher incidences of resistance were found in the very young and very old. The most prevalent serotypes in the cohort in descending order were 14, 6A, 6, 6B, 23F, 3, 19F and 11A.ConclusionsResults showed a similar but not identical profile to previously examined strains causing pulmonary infections in Hungary. The serotypes could be correlated to patient groups. Furthermore, there were examples of serotype switching in strains showing identical genotype but different serotype. The study also shows a good coverage by the conjugate vaccines over the invasive pneumococcal strains in Hungary based on the detected serotypes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Resistance, Bacterial</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Female</subject><subject>Genotype</subject><subject>Heptavalent Pneumococcal Conjugate Vaccine</subject><subject>Humans</subject><subject>Hungary - epidemiology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Phenotype</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - microbiology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines - administration & dosage</subject><subject>Retrospective Studies</subject><subject>Serotyping - methods</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - genetics</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Vaccines, Conjugate - administration & dosage</subject><subject>Young Adult</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0U2L1DAYB_Agiju7evYmBRFB7G7eJmmP67DuCusbLiJeQpo-nUltk5q0g_sd_NBm7DiClz2Fh_zyJ8kfoScEnxLCxFlrhlOK04RlKQt8Dy0IlzTnhIv7aIExJXkpuThCxzG2GBMmCXuIjiguOStIuUC_LsH58XawJtOuzobNYTQbHbQZIdioR-td5pvMuq2OdgvZ5zHAMHrjjZliNjiYeu-shsxG3-kRYtYE32dXk1vrcPvqT7bxWwh6DbugcQNpdu20TjjbamOsg_gIPWh0F-Hxfj1BN28ublZX-fWHy7er8-u84styzKuyNqRIT8CcA60olYZroEQ0TdXwmklDBZQFr3SD8ZJX2DCiMeWCF3UJwE7Qizl2CP7HBHFUvY0Guk478FNUhaQkaSHuloQSRgTFST77T7Z-Ci69QhFZEFzKVENSZ7MywccYoFFDsH36IUWw2hWqUqFqV6iaC00nnu5zp6qH-uD_NpjA8z3Q0eiuCdoZG_85tmSEMZpcPjsbR_h52NfhuxKSyaV6_2Wlvn39-K4oPlH1OvmXs6_69s5b_gZz28ch</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Dobay, Orsolya</creator><creator>Ungvári, Ágnes</creator><creator>Kardos, Szilvia</creator><creator>Kristóf, Katalin</creator><creator>Hajdú, Edit</creator><creator>Szabó, Judit</creator><creator>Knausz, Márta</creator><creator>Nagy, Erzsébet</creator><creator>Rozgonyi, Ferenc</creator><creator>Amyes, Sebastian G B</creator><creator>Nagy, Károly</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20101201</creationdate><title>Genotypic and phenotypic characterisation of invasive Streptococcus pneumoniae isolates from Hungary, and coverage of the conjugate vaccines</title><author>Dobay, Orsolya ; Ungvári, Ágnes ; Kardos, Szilvia ; Kristóf, Katalin ; Hajdú, Edit ; Szabó, Judit ; Knausz, Márta ; Nagy, Erzsébet ; Rozgonyi, Ferenc ; Amyes, Sebastian G B ; Nagy, Károly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b459t-b9dc18094044e2b227c4ae216ffbf4d37c26e984baf0054b0c31a024648d9ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Resistance, Bacterial</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Female</topic><topic>Genotype</topic><topic>Heptavalent Pneumococcal Conjugate Vaccine</topic><topic>Humans</topic><topic>Hungary - epidemiology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Phenotype</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Infections - microbiology</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal Vaccines - administration & dosage</topic><topic>Retrospective Studies</topic><topic>Serotyping - methods</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Streptococcus pneumoniae - drug effects</topic><topic>Streptococcus pneumoniae - genetics</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Vaccines, Conjugate - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobay, Orsolya</creatorcontrib><creatorcontrib>Ungvári, Ágnes</creatorcontrib><creatorcontrib>Kardos, Szilvia</creatorcontrib><creatorcontrib>Kristóf, Katalin</creatorcontrib><creatorcontrib>Hajdú, Edit</creatorcontrib><creatorcontrib>Szabó, Judit</creatorcontrib><creatorcontrib>Knausz, Márta</creatorcontrib><creatorcontrib>Nagy, Erzsébet</creatorcontrib><creatorcontrib>Rozgonyi, Ferenc</creatorcontrib><creatorcontrib>Amyes, Sebastian G B</creatorcontrib><creatorcontrib>Nagy, Károly</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobay, Orsolya</au><au>Ungvári, Ágnes</au><au>Kardos, Szilvia</au><au>Kristóf, Katalin</au><au>Hajdú, Edit</au><au>Szabó, Judit</au><au>Knausz, Márta</au><au>Nagy, Erzsébet</au><au>Rozgonyi, Ferenc</au><au>Amyes, Sebastian G B</au><au>Nagy, Károly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotypic and phenotypic characterisation of invasive Streptococcus pneumoniae isolates from Hungary, and coverage of the conjugate vaccines</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>63</volume><issue>12</issue><spage>1116</spage><epage>1120</epage><pages>1116-1120</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Background and aimsThe 7-valent conjugate pneumococcal vaccine (Prevenar) was introduced as a recommended (but not yet obligatory) vaccine in Hungary in April 2009 and there was a sharp increase in the number of children vaccinated. Hence there is an urgent need for in-depth epidemiological data on invasive pneumococci before vaccination becomes widespread. Such a study has never been done before in Hungary.Methods144 pneumococcal isolates, obtained from invasive infections or pneumonia, were collected from eight Hungarian diagnostic laboratories between 2000 and 2008. After confirmation of species identity, their susceptibilities to nine antibiotics were determined by Etest and agar dilution method. The serotypes and pulsed-field gel electrophoresis genotypes of the strains were also determined.ResultsIn this cohort, most of the isolates were from patients at the extreme of life. Only 1.4% of the strains were resistant to penicillin, but nearly 40% were resistant to erythromycin (mainly due to erm(B) gene). Higher incidences of resistance were found in the very young and very old. The most prevalent serotypes in the cohort in descending order were 14, 6A, 6, 6B, 23F, 3, 19F and 11A.ConclusionsResults showed a similar but not identical profile to previously examined strains causing pulmonary infections in Hungary. The serotypes could be correlated to patient groups. Furthermore, there were examples of serotype switching in strains showing identical genotype but different serotype. The study also shows a good coverage by the conjugate vaccines over the invasive pneumococcal strains in Hungary based on the detected serotypes.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>20943819</pmid><doi>10.1136/jcp.2010.079780</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Age Distribution Aged Aged, 80 and over Biological and medical sciences Child Child, Preschool Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Female Genotype Heptavalent Pneumococcal Conjugate Vaccine Humans Hungary - epidemiology Infant Infant, Newborn Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Microbial Sensitivity Tests - methods Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Retrospective Studies Serotyping - methods Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification Vaccines, Conjugate - administration & dosage Young Adult |
| title | Genotypic and phenotypic characterisation of invasive Streptococcus pneumoniae isolates from Hungary, and coverage of the conjugate vaccines |
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