Low levels of mannose-binding lectin confers protection against tuberculosis in Turkish children

Mannose-binding lectin (MBL) plays an important role in innate immunity mediating phagocytosis and activating the MBL complement pathway. Few studies, conducted in adult populations, have shown that genetically determined low MBL levels may confer partial protection against tuberculosis (TB). In thi...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2008-12, Vol.27 (12), p.1165-1169
Hauptverfasser: Cosar, H, Ozkinay, F, Onay, H, Bayram, N, Bakiler, A. R, Anıl, M, Can, D, Özkınay, C
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container_issue 12
container_start_page 1165
container_title European journal of clinical microbiology & infectious diseases
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creator Cosar, H
Ozkinay, F
Onay, H
Bayram, N
Bakiler, A. R
Anıl, M
Can, D
Özkınay, C
description Mannose-binding lectin (MBL) plays an important role in innate immunity mediating phagocytosis and activating the MBL complement pathway. Few studies, conducted in adult populations, have shown that genetically determined low MBL levels may confer partial protection against tuberculosis (TB). In this study we aimed to investigate the relationships between the susceptibility to TB and two low producing MBL2 gene polymorphisms (codons 54 and 57) and MBL levels in children. Forty-four TB children (27 pulmonary TB, 17 extrapulmonary TB) and 99 age-matched healthy control children were included in the study. The mean age in the study group was 7.02 ± 4.5 years. Genotyping of the MBL2 gene for codon 54 and 57 polymorphisms was carried out, and MBL levels in serum were also detected in all subjects from both groups. None of the subjects from either group showed codon 57 polymorphisms. The frequency of the AB genotype which produces low level MBL is significantly lower in the patients (9.1%) compared to control subjects (27.3%) (p < 0.011). The difference was especially significant between the extrapulmonary group and healthy controls (p < 0.006). The BB genotype was observed in only one child from the healthy controls and no children from the patient group. The median MBL plasma concentration was also significantly lower in the control group than that found in the study group (p = 0.036). These results indicate that low levels of MBL and AB genotype may be involved in the protection against tuberculosis, especially extrapulmonary tuberculosis in children.
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Genotyping of the MBL2 gene for codon 54 and 57 polymorphisms was carried out, and MBL levels in serum were also detected in all subjects from both groups. None of the subjects from either group showed codon 57 polymorphisms. The frequency of the AB genotype which produces low level MBL is significantly lower in the patients (9.1%) compared to control subjects (27.3%) (p &lt; 0.011). The difference was especially significant between the extrapulmonary group and healthy controls (p &lt; 0.006). The BB genotype was observed in only one child from the healthy controls and no children from the patient group. The median MBL plasma concentration was also significantly lower in the control group than that found in the study group (p = 0.036). 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R</creatorcontrib><creatorcontrib>Anıl, M</creatorcontrib><creatorcontrib>Can, D</creatorcontrib><creatorcontrib>Özkınay, C</creatorcontrib><title>Low levels of mannose-binding lectin confers protection against tuberculosis in Turkish children</title><title>European journal of clinical microbiology &amp; infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Mannose-binding lectin (MBL) plays an important role in innate immunity mediating phagocytosis and activating the MBL complement pathway. Few studies, conducted in adult populations, have shown that genetically determined low MBL levels may confer partial protection against tuberculosis (TB). In this study we aimed to investigate the relationships between the susceptibility to TB and two low producing MBL2 gene polymorphisms (codons 54 and 57) and MBL levels in children. 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subjects Bacterial diseases
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Child
Child, Preschool
Disease Susceptibility
Female
Gene Frequency
Genotype
Genotype & phenotype
Hospitals
Human bacterial diseases
Humans
Immune system
Infections
Infectious diseases
Internal Medicine
Lectins
Male
Mannose-Binding Lectin - blood
Mannose-Binding Lectin - genetics
Mannose-Binding Lectin - immunology
Medical Microbiology
Medical sciences
Mycobacterium
Patients
Pediatrics
Polymorphism
Polymorphism, Genetic
Tuberculosis
Tuberculosis - immunology
Tuberculosis and atypical mycobacterial infections
Turkey
title Low levels of mannose-binding lectin confers protection against tuberculosis in Turkish children
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