Preliminary investigations of the colonisation of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12

A powder preparation of the oral probiotic Streptococcus salivarius K12 has been given to 19 young otitis media-prone children following a 3-day course of amoxicillin administered as a preliminary to ventilation tube placement. In two subjects, the use of strain K12 appeared to effect the expansion...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2008-12, Vol.27 (12), p.1261-1263
Hauptverfasser: Power, D. A, Burton, J. P, Chilcott, C. N, Dawes, P. J, Tagg, J. R
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container_end_page 1263
container_issue 12
container_start_page 1261
container_title European journal of clinical microbiology & infectious diseases
container_volume 27
creator Power, D. A
Burton, J. P
Chilcott, C. N
Dawes, P. J
Tagg, J. R
description A powder preparation of the oral probiotic Streptococcus salivarius K12 has been given to 19 young otitis media-prone children following a 3-day course of amoxicillin administered as a preliminary to ventilation tube placement. In two subjects, the use of strain K12 appeared to effect the expansion of an indigenous population of inhibitory S. salivarius. In other children, strain K12 colonisation extended beyond the oral cavity to also include the nasopharynx or adenoid tissue. The relatively low proportion (33%) of subjects that colonised was attributed to failure of the amoxicillin pre-treatment to sufficiently reduce the indigenous S. salivarius populations prior to dosing with strain K12 powder.
doi_str_mv 10.1007/s10096-008-0569-4
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subjects Administration, Oral
Amoxicillin - administration & dosage
Antibiotics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brief Report
Child, Preschool
Colonization
Ear diseases
Humans
Infant
Infectious diseases
Internal Medicine
Lymphoid Tissue - microbiology
Medical Microbiology
Medical sciences
Mouth - microbiology
Nasopharynx - microbiology
Pediatrics
Probiotics
Probiotics - administration & dosage
Respiratory System - microbiology
Respiratory tract
Streptococcus - growth & development
Streptococcus salivarius
Surgery
Ventilation
title Preliminary investigations of the colonisation of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12
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