Intestinal disaccharidase activity in patients with autism: Effect of age, gender, and intestinal inflammation
Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in...
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| Veröffentlicht in: | Autism : the international journal of research and practice 2011-05, Vol.15 (3), p.285-294 |
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| creator | Kushak, Rafail I. Lauwers, Gregory Y. Winter, Harland S. Buie, Timothy M. |
| description | Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. |
| doi_str_mv | 10.1177/1362361310369142 |
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All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. 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All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history.</description><subject>Abdominal Pain - etiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age Differences</subject><subject>Age Factors</subject><subject>alpha-Glucosidases - metabolism</subject><subject>Autism</subject><subject>Autistic children</subject><subject>Autistic Disorder - enzymology</subject><subject>Autistic Disorder - epidemiology</subject><subject>Autistic Disorder - pathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Comparative Analysis</subject><subject>Cross-Sectional Studies</subject><subject>Developmental disorders</subject><subject>Diagnostic Tests</subject><subject>Discomfort</subject><subject>Diseases</subject><subject>Duodenum - enzymology</subject><subject>Duodenum - pathology</subject><subject>Female</subject><subject>Gender Differences</subject><subject>Humans</subject><subject>Infant</subject><subject>Infantile autism</subject><subject>Inflammation</subject><subject>Inflammatory Bowel Diseases - enzymology</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>Injuries</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Lactase - metabolism</subject><subject>Lactose Intolerance - enzymology</subject><subject>Lactose Intolerance - epidemiology</subject><subject>Lactose Intolerance - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Pain</subject><subject>Patients</subject><subject>Pervasive Developmental Disorders</subject><subject>Physical Health</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Small intestine</subject><subject>Sucrase - metabolism</subject><subject>Symptoms (Individual Disorders)</subject><subject>Young Adult</subject><issn>1362-3613</issn><issn>1461-7005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNp1kN1LwzAUxYMobn68-yBSEPGpmtukaeubjKmTgS_6XG7T1GW03UxSZf-9GZ1TBj4l5PzuuSeHkDOgNwBJcgtMREwAA8pEBjzaI0PgAsKE0njf370crvUBObJ2Tv0rj-GQDCLgENMMhuRu0jplnW6xDkptUcoZGl2iVQFKpz-1WwW6DZbotGqdDb60mwXYOW2bE3JQYW3V6eY8Jm8P49fRUzh9eZyM7qehZCJ1YeaDcpUkcQWyigTDLFUxlIwBKs7LAiWgQFUWgkpWRZSyqAIukYlEVQXN2DG57n2XZvHR-bB5o61UdY2tWnQ2TxPIRMqp8OTlDjlfdMZ_zeaQRSmIlHLwFO0paRbWGlXlS6MbNKscaL6uNd-t1Y9cbIy7olHlduCnRw9cbQC0EuvKYCu1_eW8BwCLPXfec8pouZXHzz4di9Z7wl62-K7-hP8v1zff5ZO6</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Kushak, Rafail I.</creator><creator>Lauwers, Gregory Y.</creator><creator>Winter, Harland S.</creator><creator>Buie, Timothy M.</creator><general>SAGE Publications</general><general>Sage Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Intestinal disaccharidase activity in patients with autism</title><author>Kushak, Rafail I. ; Lauwers, Gregory Y. ; Winter, Harland S. ; Buie, Timothy M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-91774e775f1cf263a98e51d331ae44dbac1a6aedb60c3f20032f14ca367efb093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal Pain - etiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Age Differences</topic><topic>Age Factors</topic><topic>alpha-Glucosidases - metabolism</topic><topic>Autism</topic><topic>Autistic children</topic><topic>Autistic Disorder - enzymology</topic><topic>Autistic Disorder - epidemiology</topic><topic>Autistic Disorder - pathology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Comparative Analysis</topic><topic>Cross-Sectional Studies</topic><topic>Developmental disorders</topic><topic>Diagnostic Tests</topic><topic>Discomfort</topic><topic>Diseases</topic><topic>Duodenum - enzymology</topic><topic>Duodenum - pathology</topic><topic>Female</topic><topic>Gender Differences</topic><topic>Humans</topic><topic>Infant</topic><topic>Infantile autism</topic><topic>Inflammation</topic><topic>Inflammatory Bowel Diseases - enzymology</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Inflammatory Bowel Diseases - pathology</topic><topic>Injuries</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Lactase - metabolism</topic><topic>Lactose Intolerance - enzymology</topic><topic>Lactose Intolerance - epidemiology</topic><topic>Lactose Intolerance - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Pain</topic><topic>Patients</topic><topic>Pervasive Developmental Disorders</topic><topic>Physical Health</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>Small intestine</topic><topic>Sucrase - metabolism</topic><topic>Symptoms (Individual Disorders)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kushak, Rafail I.</creatorcontrib><creatorcontrib>Lauwers, Gregory Y.</creatorcontrib><creatorcontrib>Winter, Harland S.</creatorcontrib><creatorcontrib>Buie, Timothy M.</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Autism : the international journal of research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kushak, Rafail I.</au><au>Lauwers, Gregory Y.</au><au>Winter, Harland S.</au><au>Buie, Timothy M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ928322</ericid><atitle>Intestinal disaccharidase activity in patients with autism: Effect of age, gender, and intestinal inflammation</atitle><jtitle>Autism : the international journal of research and practice</jtitle><addtitle>Autism</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>15</volume><issue>3</issue><spage>285</spage><epage>294</epage><pages>285-294</pages><issn>1362-3613</issn><eissn>1461-7005</eissn><abstract>Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21415091</pmid><doi>10.1177/1362361310369142</doi><tpages>10</tpages></addata></record> |
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| ispartof | Autism : the international journal of research and practice, 2011-05, Vol.15 (3), p.285-294 |
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| subjects | Abdominal Pain - etiology Adolescent Adult Adults Age Differences Age Factors alpha-Glucosidases - metabolism Autism Autistic children Autistic Disorder - enzymology Autistic Disorder - epidemiology Autistic Disorder - pathology Biological and medical sciences Biopsy Child Child clinical studies Child, Preschool Children Comparative Analysis Cross-Sectional Studies Developmental disorders Diagnostic Tests Discomfort Diseases Duodenum - enzymology Duodenum - pathology Female Gender Differences Humans Infant Infantile autism Inflammation Inflammatory Bowel Diseases - enzymology Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - pathology Injuries Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Lactase - metabolism Lactose Intolerance - enzymology Lactose Intolerance - epidemiology Lactose Intolerance - pathology Male Medical sciences Metabolism Pain Patients Pervasive Developmental Disorders Physical Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reference Values Retrospective Studies Small intestine Sucrase - metabolism Symptoms (Individual Disorders) Young Adult |
| title | Intestinal disaccharidase activity in patients with autism: Effect of age, gender, and intestinal inflammation |
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