Evaluation of the URIT-2900 Automated Hematology Analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations
The effectiveness of the URIT-2900 Hematology Analyzer for screening of hemoglobinopathies commonly found in Southeast Asian populations was examined. Appropriate cut-off values of MCV and MCH for screening of α 0 and β thalassemias were derived from the receiver operator characteristic curve conduc...
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| Veröffentlicht in: | Clinical biochemistry 2011-07, Vol.44 (10), p.889-893 |
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| creator | Karnpean, Rossarin Pansuwan, Anupong Fucharoen, Goonnapa Fucharoen, Supan |
| description | The effectiveness of the URIT-2900 Hematology Analyzer for screening of hemoglobinopathies commonly found in Southeast Asian populations was examined.
Appropriate cut-off values of MCV and MCH for screening of α
0 and β thalassemias were derived from the receiver operator characteristic curve conducted initially on 279 subjects with various thalassemia genotypes. Validation was performed additionally in a cohort of another unrelated 313 subjects.
The best cut off values of MCV and MCH were found to be 78
fL and 27
pg, respectively. Using these cut off values in combination with the dichlorophenolindophenol test in screening of α
0 thalassemia, β thalassemia and Hb E in a cohort study revealed 100% sensitivity, 79.6% specificity, 80.0% positive predictive value and 100% negative predictive value.
The combined blood cell counting using the URIT-2900 Automated Hematology Analyzer and dichlorophenolindophenol test is suitable for population screening of thalassemia and hemoglobinopathies in Southeast Asia. |
| doi_str_mv | 10.1016/j.clinbiochem.2011.04.009 |
| format | Article |
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Appropriate cut-off values of MCV and MCH for screening of α
0 and β thalassemias were derived from the receiver operator characteristic curve conducted initially on 279 subjects with various thalassemia genotypes. Validation was performed additionally in a cohort of another unrelated 313 subjects.
The best cut off values of MCV and MCH were found to be 78
fL and 27
pg, respectively. Using these cut off values in combination with the dichlorophenolindophenol test in screening of α
0 thalassemia, β thalassemia and Hb E in a cohort study revealed 100% sensitivity, 79.6% specificity, 80.0% positive predictive value and 100% negative predictive value.
The combined blood cell counting using the URIT-2900 Automated Hematology Analyzer and dichlorophenolindophenol test is suitable for population screening of thalassemia and hemoglobinopathies in Southeast Asia.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2011.04.009</identifier><identifier>PMID: 21539820</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Anemias. Hemoglobinopathies ; Asia, Southeastern ; Automation ; Biological and medical sciences ; Cellular Senescence ; Cohort Studies ; Diseases of red blood cells ; Erythrocyte Indices ; Genotype ; Hematologic and hematopoietic diseases ; Hematology - instrumentation ; Hemoglobins - metabolism ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Mass Screening ; Medical sciences ; Population screening ; Red blood cell indices ; Reproducibility of Results ; ROC Curve ; Thalassemia - blood ; Thalassemia - diagnosis ; Thalassemia - genetics ; Thalassemia - pathology ; Thalassemia and hemoglobinopathies ; URIT-2900 Hematology Analyzer</subject><ispartof>Clinical biochemistry, 2011-07, Vol.44 (10), p.889-893</ispartof><rights>2011 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-b1fc5c0128ecbf1efb9216ed17de8e24dc49c5b71734c06d2b70dc9a29b6e5bc3</citedby><cites>FETCH-LOGICAL-c406t-b1fc5c0128ecbf1efb9216ed17de8e24dc49c5b71734c06d2b70dc9a29b6e5bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912011003146$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24335788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21539820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karnpean, Rossarin</creatorcontrib><creatorcontrib>Pansuwan, Anupong</creatorcontrib><creatorcontrib>Fucharoen, Goonnapa</creatorcontrib><creatorcontrib>Fucharoen, Supan</creatorcontrib><title>Evaluation of the URIT-2900 Automated Hematology Analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>The effectiveness of the URIT-2900 Hematology Analyzer for screening of hemoglobinopathies commonly found in Southeast Asian populations was examined.
Appropriate cut-off values of MCV and MCH for screening of α
0 and β thalassemias were derived from the receiver operator characteristic curve conducted initially on 279 subjects with various thalassemia genotypes. Validation was performed additionally in a cohort of another unrelated 313 subjects.
The best cut off values of MCV and MCH were found to be 78
fL and 27
pg, respectively. Using these cut off values in combination with the dichlorophenolindophenol test in screening of α
0 thalassemia, β thalassemia and Hb E in a cohort study revealed 100% sensitivity, 79.6% specificity, 80.0% positive predictive value and 100% negative predictive value.
The combined blood cell counting using the URIT-2900 Automated Hematology Analyzer and dichlorophenolindophenol test is suitable for population screening of thalassemia and hemoglobinopathies in Southeast Asia.</description><subject>Anemias. Hemoglobinopathies</subject><subject>Asia, Southeastern</subject><subject>Automation</subject><subject>Biological and medical sciences</subject><subject>Cellular Senescence</subject><subject>Cohort Studies</subject><subject>Diseases of red blood cells</subject><subject>Erythrocyte Indices</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology - instrumentation</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Population screening</subject><subject>Red blood cell indices</subject><subject>Reproducibility of Results</subject><subject>ROC Curve</subject><subject>Thalassemia - blood</subject><subject>Thalassemia - diagnosis</subject><subject>Thalassemia - genetics</subject><subject>Thalassemia - pathology</subject><subject>Thalassemia and hemoglobinopathies</subject><subject>URIT-2900 Hematology Analyzer</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uEzEUhS0EoqHlFZBZIFYz2J5fL6Oo0EqVKtF2bfnnTuLIYw_2TKX0GXhoXBIKS1ZXtr5z79E5CH2kpKSEtl_2pXbWKxv0DsaSEUpLUpeE8FdoRfuuKhivqtdoRfJXwSkjZ-hdSvv8ZHXfvkVnjDYV7xlZoZ-Xj9ItcrbB4zDgeQf44fv1fd5ACF4vcxjlDAZfQZ7Bhe0Br710hyeIeAgRJx0BvPXbo1g6mRKMVmLpDc7mwtYFZX2Y5LyzkLD1-C4s-YpMM14nKz2ewrS43wbSBXozSJfg_Wmeo4evl_ebq-Lm9tv1Zn1T6Jq0c6HooBtNKOtBq4HCoDijLRjaGeiB1UbXXDeqo11Va9IapjpiNJeMqxYapatz9Pm4d4rhxwJpFqNNGpyTHsKSRN9R3jZt12aSH0kdQ0oRBjFFO8p4EJSI5y7EXvzThXjuQpBa5OCz9sPpyqJGMC_KP-Fn4NMJkElLN0TptU1_ubqqmq7vM7c5cpAzebQQRdIWvAZjI-hZmGD_w84vhVuw3w</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Karnpean, Rossarin</creator><creator>Pansuwan, Anupong</creator><creator>Fucharoen, Goonnapa</creator><creator>Fucharoen, Supan</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Evaluation of the URIT-2900 Automated Hematology Analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations</title><author>Karnpean, Rossarin ; Pansuwan, Anupong ; Fucharoen, Goonnapa ; Fucharoen, Supan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-b1fc5c0128ecbf1efb9216ed17de8e24dc49c5b71734c06d2b70dc9a29b6e5bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anemias. Hemoglobinopathies</topic><topic>Asia, Southeastern</topic><topic>Automation</topic><topic>Biological and medical sciences</topic><topic>Cellular Senescence</topic><topic>Cohort Studies</topic><topic>Diseases of red blood cells</topic><topic>Erythrocyte Indices</topic><topic>Genotype</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology - instrumentation</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Population screening</topic><topic>Red blood cell indices</topic><topic>Reproducibility of Results</topic><topic>ROC Curve</topic><topic>Thalassemia - blood</topic><topic>Thalassemia - diagnosis</topic><topic>Thalassemia - genetics</topic><topic>Thalassemia - pathology</topic><topic>Thalassemia and hemoglobinopathies</topic><topic>URIT-2900 Hematology Analyzer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karnpean, Rossarin</creatorcontrib><creatorcontrib>Pansuwan, Anupong</creatorcontrib><creatorcontrib>Fucharoen, Goonnapa</creatorcontrib><creatorcontrib>Fucharoen, Supan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karnpean, Rossarin</au><au>Pansuwan, Anupong</au><au>Fucharoen, Goonnapa</au><au>Fucharoen, Supan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the URIT-2900 Automated Hematology Analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>44</volume><issue>10</issue><spage>889</spage><epage>893</epage><pages>889-893</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>The effectiveness of the URIT-2900 Hematology Analyzer for screening of hemoglobinopathies commonly found in Southeast Asian populations was examined.
Appropriate cut-off values of MCV and MCH for screening of α
0 and β thalassemias were derived from the receiver operator characteristic curve conducted initially on 279 subjects with various thalassemia genotypes. Validation was performed additionally in a cohort of another unrelated 313 subjects.
The best cut off values of MCV and MCH were found to be 78
fL and 27
pg, respectively. Using these cut off values in combination with the dichlorophenolindophenol test in screening of α
0 thalassemia, β thalassemia and Hb E in a cohort study revealed 100% sensitivity, 79.6% specificity, 80.0% positive predictive value and 100% negative predictive value.
The combined blood cell counting using the URIT-2900 Automated Hematology Analyzer and dichlorophenolindophenol test is suitable for population screening of thalassemia and hemoglobinopathies in Southeast Asia.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21539820</pmid><doi>10.1016/j.clinbiochem.2011.04.009</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anemias. Hemoglobinopathies Asia, Southeastern Automation Biological and medical sciences Cellular Senescence Cohort Studies Diseases of red blood cells Erythrocyte Indices Genotype Hematologic and hematopoietic diseases Hematology - instrumentation Hemoglobins - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Mass Screening Medical sciences Population screening Red blood cell indices Reproducibility of Results ROC Curve Thalassemia - blood Thalassemia - diagnosis Thalassemia - genetics Thalassemia - pathology Thalassemia and hemoglobinopathies URIT-2900 Hematology Analyzer |
| title | Evaluation of the URIT-2900 Automated Hematology Analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations |
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