Analgesic Effect of Diprospan in Rats with Trigeminal Neuralgia
This study examined the analgesic effect of diprospan in rats with trigeminal neuralgia.Rat model of trigeminal neuralgic pain was established by loosely ligating the left infraorbital branch of the trigeminal nerve.After allodynia developed,the rats were randomly divided into 2 groups（n=20 in each）...
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| Veröffentlicht in: | Journal of Huazhong University of Science and Technology. Medical sciences 2011-06, Vol.31 (3), p.395-399 |
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| creator | 王延秀 李晓光 曹灵敏 田玉科 |
| description | This study examined the analgesic effect of diprospan in rats with trigeminal neuralgia.Rat model of trigeminal neuralgic pain was established by loosely ligating the left infraorbital branch of the trigeminal nerve.After allodynia developed,the rats were randomly divided into 2 groups（n=20 in each）：diprospan group,in which the rats received diprospan（7 mg/mL,0.1 mL） injected to the left infraorbital foramen area;control group,in which saline（0.1 mL） was administered as the same manner as the diprospan group.The pain threshold（PT） in the left infraorbital area was measured before and 2,6,and 8 weeks after the administration.The expression of neuropeptides [substance P,preprotachykinin A（PPTA）,calcitonin gene-related peptide（CGRP）] in the trigeminal nerve was detected at the same time points as the PT measurement by immunohistochemistry or in situ hybridization method.The results showed that in the diprospan group,the PT was 10.65±1.26,10.77±1.19 and 14.13±1.34 g 2,6,and 8 weeks after the administration respectively,significantly higher than that before the administration（PT value：0.36±0.11）（P0.05 for each）.In the saline group,the PT was 0.37±0.13,0.66±0.09,4.45±1.29 and 13.72±1.72 g before and 2,6,and 8 weeks after the administration respectively with differences being significant between before and 6,8 weeks after the administration（P0.01）.No significant difference existed in the PT between the diprospan group and the saline group at pre-administration（P0.05）.The PT in the diprospan group was significantly greater than that in the saline group 2 and 6 weeks post-administration（P0.05）.In the diprospan group,the expression levels of neuropeptides were significantly reduced as compared with those in the saline group 2 and 6 weeks post-administration（P0.05）.It was concluded that diprospan has an obvious analgesic effect on the trigeminal neuropathic pain partly by reducing the expression of neuropeptides in the trigeminal ganglia. |
| doi_str_mv | 10.1007/s11596-011-0388-1 |
| format | Article |
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Medical sciences, 2011-06, Vol.31 (3), p.395-399</ispartof><rights>Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2011</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-9c61f7883b91f3397093493917c18df54e1286093825f7d9106ac7ecf4d52bf93</citedby><cites>FETCH-LOGICAL-c402t-9c61f7883b91f3397093493917c18df54e1286093825f7d9106ac7ecf4d52bf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85740A/85740A.jpg</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21671185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>王延秀 李晓光 曹灵敏 田玉科</creatorcontrib><title>Analgesic Effect of Diprospan in Rats with Trigeminal Neuralgia</title><title>Journal of Huazhong University of Science and Technology. Medical sciences</title><addtitle>J. Huazhong Univ. Sci. Technol. [Med. Sci.]</addtitle><addtitle>Journal of Zuazhong University of Science and Technology： Medical Edition</addtitle><description>This study examined the analgesic effect of diprospan in rats with trigeminal neuralgia.Rat model of trigeminal neuralgic pain was established by loosely ligating the left infraorbital branch of the trigeminal nerve.After allodynia developed,the rats were randomly divided into 2 groups（n=20 in each）：diprospan group,in which the rats received diprospan（7 mg/mL,0.1 mL） injected to the left infraorbital foramen area;control group,in which saline（0.1 mL） was administered as the same manner as the diprospan group.The pain threshold（PT） in the left infraorbital area was measured before and 2,6,and 8 weeks after the administration.The expression of neuropeptides [substance P,preprotachykinin A（PPTA）,calcitonin gene-related peptide（CGRP）] in the trigeminal nerve was detected at the same time points as the PT measurement by immunohistochemistry or in situ hybridization method.The results showed that in the diprospan group,the PT was 10.65±1.26,10.77±1.19 and 14.13±1.34 g 2,6,and 8 weeks after the administration respectively,significantly higher than that before the administration（PT value：0.36±0.11）（P0.05 for each）.In the saline group,the PT was 0.37±0.13,0.66±0.09,4.45±1.29 and 13.72±1.72 g before and 2,6,and 8 weeks after the administration respectively with differences being significant between before and 6,8 weeks after the administration（P0.01）.No significant difference existed in the PT between the diprospan group and the saline group at pre-administration（P0.05）.The PT in the diprospan group was significantly greater than that in the saline group 2 and 6 weeks post-administration（P0.05）.In the diprospan group,the expression levels of neuropeptides were significantly reduced as compared with those in the saline group 2 and 6 weeks post-administration（P0.05）.It was concluded that diprospan has an obvious analgesic effect on the trigeminal neuropathic pain partly by reducing the expression of neuropeptides in the trigeminal ganglia.</description><subject>Analgesics</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Betamethasone - analogs & derivatives</subject><subject>Betamethasone - therapeutic use</subject><subject>Calcitonin gene-related peptide</subject><subject>Calcitonin Gene-Related Peptide - metabolism</subject><subject>Drug Combinations</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuralgia</subject><subject>Neuropathy</subject><subject>Neuropeptides</subject><subject>Pain perception</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Substance P</subject><subject>Substance P - metabolism</subject><subject>Trigeminal ganglion</subject><subject>Trigeminal nerve</subject><subject>Trigeminal Neuralgia - drug therapy</subject><subject>Trigeminal Neuralgia - etiology</subject><subject>Trigeminal Neuralgia - metabolism</subject><subject>三叉神经节</subject><subject>大鼠模型</subject><subject>松散</subject><subject>治疗</subject><subject>生理盐水</subject><subject>神经痛</subject><subject>镇痛作用</subject><subject>降钙素基因相关肽</subject><issn>1672-0733</issn><issn>1993-1352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1PwjAchhujEUT_AC9mnvQy7a9dv06GIH4kRBOD52Z0LZTABusW439vyZAjpzb9Pe_b9kHoGvADYCweAwBTPMUAKaZSpnCC-qAUTYEychr3XJAUC0p76CKEJcZMcJKdox6JEwDJ-uhpWOaruQ3eJGPnrGmSyiXPflNXYZOXiS-Tr7wJyY9vFsm09nO79jGQfNi2jjmfX6Izl6-CvdqvA_T9Mp6O3tLJ5-v7aDhJTYZJkyrDwQkp6UyBo1QJrGimqAJhQBaOZRaI5PFQEuZEoQDz3AhrXFYwMnOKDtBd1xtftm1taPTaB2NXq7y0VRu0FKA4iyYieX-UjBcxLAXmMqLQoSZ-N9TW6U3t13n9qwHrnWHdGdaxV-8M6139zb6-na1tcUj8K40A6YAQR-Xc1npZtXWUFo623u5fsqjK-TbmDsVU0owDJvQP0mCOoQ</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>王延秀 李晓光 曹灵敏 田玉科</creator><general>Huazhong University of Science and Technology</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Analgesic Effect of Diprospan in Rats with Trigeminal Neuralgia</title><author>王延秀 李晓光 曹灵敏 田玉科</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-9c61f7883b91f3397093493917c18df54e1286093825f7d9106ac7ecf4d52bf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analgesics</topic><topic>Analgesics - therapeutic use</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Betamethasone - analogs & derivatives</topic><topic>Betamethasone - therapeutic use</topic><topic>Calcitonin gene-related peptide</topic><topic>Calcitonin Gene-Related Peptide - metabolism</topic><topic>Drug Combinations</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuralgia</topic><topic>Neuropathy</topic><topic>Neuropeptides</topic><topic>Pain perception</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Substance P</topic><topic>Substance P - metabolism</topic><topic>Trigeminal ganglion</topic><topic>Trigeminal nerve</topic><topic>Trigeminal Neuralgia - drug therapy</topic><topic>Trigeminal Neuralgia - etiology</topic><topic>Trigeminal Neuralgia - metabolism</topic><topic>三叉神经节</topic><topic>大鼠模型</topic><topic>松散</topic><topic>治疗</topic><topic>生理盐水</topic><topic>神经痛</topic><topic>镇痛作用</topic><topic>降钙素基因相关肽</topic><toplevel>online_resources</toplevel><creatorcontrib>王延秀 李晓光 曹灵敏 田玉科</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>王延秀 李晓光 曹灵敏 田玉科</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic Effect of Diprospan in Rats with Trigeminal Neuralgia</atitle><jtitle>Journal of Huazhong University of Science and Technology. Medical sciences</jtitle><stitle>J. Huazhong Univ. Sci. Technol. [Med. Sci.]</stitle><addtitle>Journal of Zuazhong University of Science and Technology： Medical Edition</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>31</volume><issue>3</issue><spage>395</spage><epage>399</epage><pages>395-399</pages><issn>1672-0733</issn><eissn>1993-1352</eissn><abstract>This study examined the analgesic effect of diprospan in rats with trigeminal neuralgia.Rat model of trigeminal neuralgic pain was established by loosely ligating the left infraorbital branch of the trigeminal nerve.After allodynia developed,the rats were randomly divided into 2 groups（n=20 in each）：diprospan group,in which the rats received diprospan（7 mg/mL,0.1 mL） injected to the left infraorbital foramen area;control group,in which saline（0.1 mL） was administered as the same manner as the diprospan group.The pain threshold（PT） in the left infraorbital area was measured before and 2,6,and 8 weeks after the administration.The expression of neuropeptides [substance P,preprotachykinin A（PPTA）,calcitonin gene-related peptide（CGRP）] in the trigeminal nerve was detected at the same time points as the PT measurement by immunohistochemistry or in situ hybridization method.The results showed that in the diprospan group,the PT was 10.65±1.26,10.77±1.19 and 14.13±1.34 g 2,6,and 8 weeks after the administration respectively,significantly higher than that before the administration（PT value：0.36±0.11）（P0.05 for each）.In the saline group,the PT was 0.37±0.13,0.66±0.09,4.45±1.29 and 13.72±1.72 g before and 2,6,and 8 weeks after the administration respectively with differences being significant between before and 6,8 weeks after the administration（P0.01）.No significant difference existed in the PT between the diprospan group and the saline group at pre-administration（P0.05）.The PT in the diprospan group was significantly greater than that in the saline group 2 and 6 weeks post-administration（P0.05）.In the diprospan group,the expression levels of neuropeptides were significantly reduced as compared with those in the saline group 2 and 6 weeks post-administration（P0.05）.It was concluded that diprospan has an obvious analgesic effect on the trigeminal neuropathic pain partly by reducing the expression of neuropeptides in the trigeminal ganglia.</abstract><cop>Heidelberg</cop><pub>Huazhong University of Science and Technology</pub><pmid>21671185</pmid><doi>10.1007/s11596-011-0388-1</doi><tpages>5</tpages></addata></record> |
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| issn | 1672-0733 1993-1352 |
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| subjects | Analgesics Analgesics - therapeutic use Animals Anti-Inflammatory Agents - therapeutic use Betamethasone - analogs & derivatives Betamethasone - therapeutic use Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - metabolism Drug Combinations Immunohistochemistry Male Medicine Medicine & Public Health Neuralgia Neuropathy Neuropeptides Pain perception Rats Rats, Wistar Substance P Substance P - metabolism Trigeminal ganglion Trigeminal nerve Trigeminal Neuralgia - drug therapy Trigeminal Neuralgia - etiology Trigeminal Neuralgia - metabolism 三叉神经节 大鼠模型 松散 治疗 生理盐水 神经痛 镇痛作用 降钙素基因相关肽 |
| title | Analgesic Effect of Diprospan in Rats with Trigeminal Neuralgia |
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