The regulation and physiology of mitochondrial proton leak

Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Physiology (Bethesda, Md.) Md.), 2011-06, Vol.26 (3), p.192-205
Hauptverfasser:	Divakaruni, Ajit S, Brand, Martin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aging - metabolism Animals Anti-Obesity Agents - pharmacology Energy Metabolism Humans Hypoglycemic Agents - pharmacology Ion Channels - metabolism Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membranes - drug effects Mitochondrial Membranes - metabolism Mitochondrial Proteins - metabolism Proton-Motive Force Uncoupling Protein 1 Uncoupling Protein 2 Uncoupling Protein 3
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.
ISSN:	1548-9213 1548-9221
DOI:	10.1152/physiol.00046.2010