The NFKB1 (g.-24519delATTG) Variant is Associated with Necrotizing Enterocolitis (NEC) in Premature Infants

Objective While it is known that gene–environment interactions contribute to necrotizing enterocolitis (NEC) pathogenesis, characterization of genetic risk-factors that can predict NEC in preterm infants remains nascent. We hypothesized that altered intestinal immune responses arising from sequence...

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Veröffentlicht in:	The Journal of surgical research 2011-07, Vol.169 (1), p.e51-e57
Hauptverfasser:	Sampath, Venkatesh, M.B.B.S., M.R.C.P.Ch, Le, Min, Ph.D, Lane, Laura, B.S.N, Patel, Aloka L., M.D, Cohen, Jonathan D., M.D, Simpson, Pippa M., Ph.D, Garland, Jeffery S., M.D, Hines, Ronald N., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Case-Control Studies Cohort Studies Enterocolitis, Necrotizing - epidemiology Enterocolitis, Necrotizing - genetics Enterocolitis, Necrotizing - physiopathology Female Genetic Predisposition to Disease - genetics genetic susceptibility Humans Incidence Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Male necrotizing enterocolitis NF-kappa B p50 Subunit - genetics NF-κB variant Pilot Projects Polymorphism, Single Nucleotide - genetics premature infant Prospective Studies Retrospective Studies Signal Transduction - physiology single nucleotide polymorphisms Surgery toll-like receptors Toll-Like Receptors - physiology
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