Bioactive Sesqui- and Diterpenoids from the Argentine Liverwort Porella chilensis

Four fusicoccane-type diterpenoids (1−4), including the new 1 and 2; four pinguisane-type sesquiterpenoids (5−8); and two aromadendrane-type sesquiterpenoids (9 and 10) were isolated from an Argentine collection of the endemic liverwort Porella chilensis. The biofilm formation of the human pathogen...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-04, Vol.74 (4), p.574-579
Hauptverfasser:	Gilabert, Miguel, Ramos, Alberto N, Schiavone, María M, Arena, Mario E, Bardón, Alicia
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Sprache:	eng
Schlagworte:	Argentina Biofilms - drug effects Biological and medical sciences Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology General pharmacology Hepatophyta - chemistry Humans Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Pseudomonas aeruginosa - physiology Quorum Sensing Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
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container_title	Journal of natural products (Washington, D.C.)
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creator	Gilabert, Miguel Ramos, Alberto N Schiavone, María M Arena, Mario E Bardón, Alicia
description	Four fusicoccane-type diterpenoids (1−4), including the new 1 and 2; four pinguisane-type sesquiterpenoids (5−8); and two aromadendrane-type sesquiterpenoids (9 and 10) were isolated from an Argentine collection of the endemic liverwort Porella chilensis. The biofilm formation of the human pathogen Pseudomonas aeruginosa was inhibited by compounds 3 (53 and 47%), 9 (45 and 41%), and 10 (48 and 37%) at 50 and 5 μg/mL, respectively. Compounds 3, 9, and 10 also produced a slight decrease in bacterial growth and interfere with the process of quorum sensing at the same doses.
doi_str_mv	10.1021/np100472d
format	Article
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The biofilm formation of the human pathogen Pseudomonas aeruginosa was inhibited by compounds 3 (53 and 47%), 9 (45 and 41%), and 10 (48 and 37%) at 50 and 5 μg/mL, respectively. Compounds 3, 9, and 10 also produced a slight decrease in bacterial growth and interfere with the process of quorum sensing at the same doses.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np100472d</identifier><identifier>PMID: 21384863</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Northbrook, IL: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Argentina ; Biofilms - drug effects ; Biological and medical sciences ; Diterpenes - chemistry ; Diterpenes - isolation & purification ; Diterpenes - pharmacology ; General pharmacology ; Hepatophyta - chemistry ; Humans ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudomonas aeruginosa - physiology</topic><topic>Quorum Sensing</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilabert, Miguel</creatorcontrib><creatorcontrib>Ramos, Alberto N</creatorcontrib><creatorcontrib>Schiavone, María M</creatorcontrib><creatorcontrib>Arena, Mario E</creatorcontrib><creatorcontrib>Bardón, Alicia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilabert, Miguel</au><au>Ramos, Alberto N</au><au>Schiavone, María M</au><au>Arena, Mario E</au><au>Bardón, Alicia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive Sesqui- and Diterpenoids from the Argentine Liverwort Porella chilensis</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2011-04-25</date><risdate>2011</risdate><volume>74</volume><issue>4</issue><spage>574</spage><epage>579</epage><pages>574-579</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Four fusicoccane-type diterpenoids (1−4), including the new 1 and 2; four pinguisane-type sesquiterpenoids (5−8); and two aromadendrane-type sesquiterpenoids (9 and 10) were isolated from an Argentine collection of the endemic liverwort Porella chilensis. The biofilm formation of the human pathogen Pseudomonas aeruginosa was inhibited by compounds 3 (53 and 47%), 9 (45 and 41%), and 10 (48 and 37%) at 50 and 5 μg/mL, respectively. 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subjects	Argentina Biofilms - drug effects Biological and medical sciences Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology General pharmacology Hepatophyta - chemistry Humans Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Pseudomonas aeruginosa - physiology Quorum Sensing Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
title	Bioactive Sesqui- and Diterpenoids from the Argentine Liverwort Porella chilensis
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