Sevoflurane inhibits angiotensin II-induced Rho kinase-mediated contraction of vascular smooth muscle from spontaneously hypertensive rat

Purpose Angiotensin II (Ang II)-induced vasoconstriction is mediated by changes in intracellular free Ca 2+ concentration ([Ca 2+ ] i ) and myofilament Ca 2+ sensitivity. Protein kinase C- and Rho kinase-mediated signaling pathways are proposed for the regulation of the Ca 2+ sensitization mechanism...

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Veröffentlicht in:	Journal of anesthesia 2011-06, Vol.25 (3), p.398-404
Hauptverfasser:	Uematsu, Nobuhiko, Ogawa, Koji, Tokinaga, Yasuyuki, Tange, Kazuaki, Hatano, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Anesthesiology Anesthetics Anesthetics, Inhalation - pharmacology Angiotensin Angiotensin II - antagonists & inhibitors Angiotensin II - pharmacology Animals Aorta, Thoracic - drug effects Blood Pressure - drug effects Calcium - metabolism Calcium Signaling - drug effects Critical Care Medicine Emergency Medicine Enzyme Inhibitors - pharmacology Hypertension In Vitro Techniques Intensive Isometric Contraction - drug effects Male Medicine Medicine & Public Health Methyl Ethers - pharmacology Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Original Article Pain Medicine Protein Transport Pyridines - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY rho-Associated Kinases - antagonists & inhibitors Sevoflurane Smooth muscle
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