AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study

Aims/hypothesis The hypoglycaemic actions of metformin have been proposed to be mediated by hepatic AMP-activated protein kinase (AMPK). As the effects of metformin and the role of AMPK in adipose tissue remain poorly characterised, we examined the effect of metformin on AMPK activity in adipose tis...

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Veröffentlicht in:	Diabetologia 2011-07, Vol.54 (7), p.1799-1809
Hauptverfasser:	Boyle, J. G., Logan, P. J., Jones, G. C., Small, M., Sattar, N., Connell, J. M. C., Cleland, S. J., Salt, I. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Aged AMP-Activated Protein Kinases - metabolism Biological and medical sciences Body fat Cross-Over Studies Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Gliclazide - therapeutic use Glucose Human Physiology Humans Hypoglycemic Agents - therapeutic use Insulin Internal Medicine Kinases Lipids Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Metformin - therapeutic use Middle Aged Phosphorylation Proteins
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