Role of YAP/TAZ in mechanotransduction

Cells perceive their microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple asp...

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Veröffentlicht in:	Nature (London) 2011-06, Vol.474 (7350), p.179-183
Hauptverfasser:	Dupont, Sirio, Morsut, Leonardo, Aragona, Mariaceleste, Enzo, Elena, Giulitti, Stefano, Cordenonsi, Michelangelo, Zanconato, Francesca, Le Digabel, Jimmy, Forcato, Mattia, Bicciato, Silvio, Elvassore, Nicola, Piccolo, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism 631/80/641/83/2360 631/80/79/2066 Active Transport, Cell Nucleus Adaptor Proteins, Signal Transducing - metabolism Animals Biological and medical sciences Cell Cycle Proteins Cell Differentiation Cell Line Cell physiology Cell Shape Cell Survival Cellular biology Cues Cytoskeleton Cytoskeleton - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Extracellular Matrix - metabolism Fundamental and applied biological sciences. Psychology Homeostasis Humanities and Social Sciences Humans Hydrogels Intracellular Signaling Peptides and Proteins - metabolism Mechanical properties Mechanotransduction, Cellular - physiology Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mice Molecular and cellular biology multidisciplinary Nuclear Proteins - metabolism Phosphoproteins - metabolism Rigidity Science Science (multidisciplinary) Signal transduction Stem cells Trans-Activators Transcription Factors - metabolism
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