Use of Medications and Resources for Treatment of Nausea, Vomiting, or Constipation in Hospitalized Patients Treated With Analgesics
OBJECTIVESHospitalized patients often experience adverse events of the gastrointestinal tract due to analgesic treatment. The objectives of this study were to estimate use of medications for treatment of nausea, vomiting, or constipation (NVC medications) after initiation of analgesic treatment, and...
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| Veröffentlicht in: | The Clinical journal of pain 2011-07, Vol.27 (6), p.508-517 |
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| creator | Suh, Dong-Churl Kim, Myoung S Chow, Wing Jang, Eun-Jin |
| description | OBJECTIVESHospitalized patients often experience adverse events of the gastrointestinal tract due to analgesic treatment. The objectives of this study were to estimate use of medications for treatment of nausea, vomiting, or constipation (NVC medications) after initiation of analgesic treatment, and to compare differences in length of stay and treatment costs between patients who received NVC medications and those who did not.
METHODSThis retrospective cohort study used the Premier Perspective data from January 1, 2005 to December 31, 2007 and stratified inpatients into 4 groups based on the first analgesic agent they were given. Patients were observed for 14 days after the first analgesic use until a regimen change, first use of NVC medication, or hospital discharge, whichever occurred first. Data were analyzed using a Cox proportional hazards model and a generalized linear model.
RESULTSThis study found that 239,183 (55.1%) of 434,304 patients received NVC medications after analgesic administration. Compared with oral nonopioid analgesics, the risk of using NVC medication was 4.8 times higher for injectable opioid analgesics after controlling for confounders. Patients who received NVC medications were hospitalized 0.26 days longer (P |
| doi_str_mv | 10.1097/AJP.0b013e31820d9b76 |
| format | Article |
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METHODSThis retrospective cohort study used the Premier Perspective data from January 1, 2005 to December 31, 2007 and stratified inpatients into 4 groups based on the first analgesic agent they were given. Patients were observed for 14 days after the first analgesic use until a regimen change, first use of NVC medication, or hospital discharge, whichever occurred first. Data were analyzed using a Cox proportional hazards model and a generalized linear model.
RESULTSThis study found that 239,183 (55.1%) of 434,304 patients received NVC medications after analgesic administration. Compared with oral nonopioid analgesics, the risk of using NVC medication was 4.8 times higher for injectable opioid analgesics after controlling for confounders. Patients who received NVC medications were hospitalized 0.26 days longer (P<0.0001) at an additional cost of $756 per patient compared with patients who did not receive NVC medications (P<0.0001).
DISCUSSIONUse of an analgesic with improved gastrointestinal tolerability may potentially reduce use of NVC medications and hospital resources.</description><identifier>ISSN: 0749-8047</identifier><identifier>EISSN: 1536-5409</identifier><identifier>DOI: 10.1097/AJP.0b013e31820d9b76</identifier><identifier>PMID: 21368666</identifier><identifier>CODEN: CJPAEU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Analgesics - adverse effects ; Antiemetics - economics ; Antiemetics - therapeutic use ; Biological and medical sciences ; Cathartics - economics ; Cathartics - therapeutic use ; Cohort Studies ; Constipation - chemically induced ; Constipation - drug therapy ; Constipation - economics ; Female ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Diseases - chemically induced ; Gastrointestinal Diseases - drug therapy ; Gastrointestinal Diseases - economics ; Health Care Costs ; Humans ; Length of Stay ; Male ; Medical sciences ; Middle Aged ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Nausea - chemically induced ; Nausea - drug therapy ; Nausea - economics ; Neurology ; Proportional Hazards Models ; Retrospective Studies ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs ; Vomiting - chemically induced ; Vomiting - drug therapy ; Vomiting - economics ; Young Adult</subject><ispartof>The Clinical journal of pain, 2011-07, Vol.27 (6), p.508-517</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4106-6e37671228de6a7851f17e8042b2e37da40059e57d2bec1d0d82979eda7444983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24258989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21368666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suh, Dong-Churl</creatorcontrib><creatorcontrib>Kim, Myoung S</creatorcontrib><creatorcontrib>Chow, Wing</creatorcontrib><creatorcontrib>Jang, Eun-Jin</creatorcontrib><title>Use of Medications and Resources for Treatment of Nausea, Vomiting, or Constipation in Hospitalized Patients Treated With Analgesics</title><title>The Clinical journal of pain</title><addtitle>Clin J Pain</addtitle><description>OBJECTIVESHospitalized patients often experience adverse events of the gastrointestinal tract due to analgesic treatment. The objectives of this study were to estimate use of medications for treatment of nausea, vomiting, or constipation (NVC medications) after initiation of analgesic treatment, and to compare differences in length of stay and treatment costs between patients who received NVC medications and those who did not.
METHODSThis retrospective cohort study used the Premier Perspective data from January 1, 2005 to December 31, 2007 and stratified inpatients into 4 groups based on the first analgesic agent they were given. Patients were observed for 14 days after the first analgesic use until a regimen change, first use of NVC medication, or hospital discharge, whichever occurred first. Data were analyzed using a Cox proportional hazards model and a generalized linear model.
RESULTSThis study found that 239,183 (55.1%) of 434,304 patients received NVC medications after analgesic administration. Compared with oral nonopioid analgesics, the risk of using NVC medication was 4.8 times higher for injectable opioid analgesics after controlling for confounders. Patients who received NVC medications were hospitalized 0.26 days longer (P<0.0001) at an additional cost of $756 per patient compared with patients who did not receive NVC medications (P<0.0001).
DISCUSSIONUse of an analgesic with improved gastrointestinal tolerability may potentially reduce use of NVC medications and hospital resources.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesics - adverse effects</subject><subject>Antiemetics - economics</subject><subject>Antiemetics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cathartics - economics</subject><subject>Cathartics - therapeutic use</subject><subject>Cohort Studies</subject><subject>Constipation - chemically induced</subject><subject>Constipation - drug therapy</subject><subject>Constipation - economics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Diseases - chemically induced</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - economics</subject><subject>Health Care Costs</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nausea - chemically induced</subject><subject>Nausea - drug therapy</subject><subject>Nausea - economics</subject><subject>Neurology</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - drug therapy</subject><subject>Vomiting - economics</subject><subject>Young Adult</subject><issn>0749-8047</issn><issn>1536-5409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxS0EokvhGyDkC-LSFNtx_Oe4WgEFFahQC8fIiSddQxIvHkcVnPnguOwCEgdOI8383puZR8hjzk45s_r5-s3FKesYr6HmRjBvO63ukBVvalU1ktm7ZMW0tJVhUh-RB4ifGeONMOw-ORK8VkYptSI_rhBoHOhb8KF3OcQZqZs9_QAYl9QD0iEmepnA5QnmfIu-cwuCO6Ef4xRymK9PaCE2RZjD7pcDDTM9i7gL2Y3hO3h6UdpFjHuf0vgU8pauZzdeA4YeH5J7gxsRHh3qMbl6-eJyc1adv3_1erM-r3rJmaoU1FppLoTxoJw2DR-4hvKf6EQZeScZayw02osOeu6ZN8JqC95pKaU19TF5tvfdpfh1AcztFLCHcXQzxAVbo3ldbK0upNyTfYqICYZ2l8Lk0reWs_Y2_rbE3_4bf5E9OSxYugn8H9HvvAvw9AA47N04JDf3Af9yUjTGGls4s-du4pgh4ZdxuYHUbsGNefv_G34CjtShVA</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Suh, Dong-Churl</creator><creator>Kim, Myoung S</creator><creator>Chow, Wing</creator><creator>Jang, Eun-Jin</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201107</creationdate><title>Use of Medications and Resources for Treatment of Nausea, Vomiting, or Constipation in Hospitalized Patients Treated With Analgesics</title><author>Suh, Dong-Churl ; Kim, Myoung S ; Chow, Wing ; Jang, Eun-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4106-6e37671228de6a7851f17e8042b2e37da40059e57d2bec1d0d82979eda7444983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analgesics - adverse effects</topic><topic>Antiemetics - economics</topic><topic>Antiemetics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cathartics - economics</topic><topic>Cathartics - therapeutic use</topic><topic>Cohort Studies</topic><topic>Constipation - chemically induced</topic><topic>Constipation - drug therapy</topic><topic>Constipation - economics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Diseases - chemically induced</topic><topic>Gastrointestinal Diseases - drug therapy</topic><topic>Gastrointestinal Diseases - economics</topic><topic>Health Care Costs</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Nausea - chemically induced</topic><topic>Nausea - drug therapy</topic><topic>Nausea - economics</topic><topic>Neurology</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - drug therapy</topic><topic>Vomiting - economics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suh, Dong-Churl</creatorcontrib><creatorcontrib>Kim, Myoung S</creatorcontrib><creatorcontrib>Chow, Wing</creatorcontrib><creatorcontrib>Jang, Eun-Jin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Clinical journal of pain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suh, Dong-Churl</au><au>Kim, Myoung S</au><au>Chow, Wing</au><au>Jang, Eun-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Medications and Resources for Treatment of Nausea, Vomiting, or Constipation in Hospitalized Patients Treated With Analgesics</atitle><jtitle>The Clinical journal of pain</jtitle><addtitle>Clin J Pain</addtitle><date>2011-07</date><risdate>2011</risdate><volume>27</volume><issue>6</issue><spage>508</spage><epage>517</epage><pages>508-517</pages><issn>0749-8047</issn><eissn>1536-5409</eissn><coden>CJPAEU</coden><abstract>OBJECTIVESHospitalized patients often experience adverse events of the gastrointestinal tract due to analgesic treatment. The objectives of this study were to estimate use of medications for treatment of nausea, vomiting, or constipation (NVC medications) after initiation of analgesic treatment, and to compare differences in length of stay and treatment costs between patients who received NVC medications and those who did not.
METHODSThis retrospective cohort study used the Premier Perspective data from January 1, 2005 to December 31, 2007 and stratified inpatients into 4 groups based on the first analgesic agent they were given. Patients were observed for 14 days after the first analgesic use until a regimen change, first use of NVC medication, or hospital discharge, whichever occurred first. Data were analyzed using a Cox proportional hazards model and a generalized linear model.
RESULTSThis study found that 239,183 (55.1%) of 434,304 patients received NVC medications after analgesic administration. Compared with oral nonopioid analgesics, the risk of using NVC medication was 4.8 times higher for injectable opioid analgesics after controlling for confounders. Patients who received NVC medications were hospitalized 0.26 days longer (P<0.0001) at an additional cost of $756 per patient compared with patients who did not receive NVC medications (P<0.0001).
DISCUSSIONUse of an analgesic with improved gastrointestinal tolerability may potentially reduce use of NVC medications and hospital resources.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>21368666</pmid><doi>10.1097/AJP.0b013e31820d9b76</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Analgesics - adverse effects Antiemetics - economics Antiemetics - therapeutic use Biological and medical sciences Cathartics - economics Cathartics - therapeutic use Cohort Studies Constipation - chemically induced Constipation - drug therapy Constipation - economics Female Fundamental and applied biological sciences. Psychology Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - economics Health Care Costs Humans Length of Stay Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nausea - chemically induced Nausea - drug therapy Nausea - economics Neurology Proportional Hazards Models Retrospective Studies Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs Vomiting - chemically induced Vomiting - drug therapy Vomiting - economics Young Adult |
| title | Use of Medications and Resources for Treatment of Nausea, Vomiting, or Constipation in Hospitalized Patients Treated With Analgesics |
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