Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice
Epilepsy is a chronic neurological disorder affecting 1% population worldwide. A number of experimental studies have reported anticonvulsant, neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. The present study was designed to explor...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2011-06, Vol.18 (8), p.756-759 |
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| creator | Agarwal, Nidhi Bharal Jain, Seema Agarwal, Nitin K. Mediratta, Pramod K. Sharma, Krishna K. |
| description | Epilepsy is a chronic neurological disorder affecting 1% population worldwide. A number of experimental studies have reported anticonvulsant, neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. The present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200
mg/kg, orally (p.o.) pentylenetetrazole-induced kindling in mice. Further two oxidative stress markers viz., malondialdehyde (MDA) and glutathione were estimated in brain tissues of rodents. Curcumin (50, 100 and 200
mg/kg, p.o.) dose dependently suppressed the progression of kindling in mice. In addition, the increased levels of MDA and glutathione were also reduced by curcumin in kindled animals. These results suggest that curcumin appears to possess protective activity against kindling in mice. |
| doi_str_mv | 10.1016/j.phymed.2010.11.007 |
| format | Article |
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mg/kg, orally (p.o.) pentylenetetrazole-induced kindling in mice. Further two oxidative stress markers viz., malondialdehyde (MDA) and glutathione were estimated in brain tissues of rodents. Curcumin (50, 100 and 200
mg/kg, p.o.) dose dependently suppressed the progression of kindling in mice. In addition, the increased levels of MDA and glutathione were also reduced by curcumin in kindled animals. These results suggest that curcumin appears to possess protective activity against kindling in mice.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2010.11.007</identifier><identifier>PMID: 21211953</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Anticonvulsant ; Anticonvulsants - pharmacology ; Care and treatment ; Curcuma ; Curcumin ; Curcumin - pharmacology ; Disease Models, Animal ; Epilepsy ; Epilepsy - drug therapy ; Female ; Glutathione - metabolism ; Health aspects ; Kindling ; Kindling, Neurologic - drug effects ; Male ; Malondialdehyde - metabolism ; Mice ; Mice, Inbred Strains ; Oxidative stress ; Oxidative Stress - drug effects ; Phytotherapy ; Plant Extracts - pharmacology ; Protective Agents - pharmacology ; Turmeric</subject><ispartof>Phytomedicine (Stuttgart), 2011-06, Vol.18 (8), p.756-759</ispartof><rights>2010 Elsevier GmbH</rights><rights>Copyright © 2010 Elsevier GmbH. All rights reserved.</rights><rights>COPYRIGHT 2011 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-c8f50a34601d5586a9f32e6150d51b5811f2dede4fcc2b2e25f0efed7955831f3</citedby><cites>FETCH-LOGICAL-c490t-c8f50a34601d5586a9f32e6150d51b5811f2dede4fcc2b2e25f0efed7955831f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2010.11.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21211953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agarwal, Nidhi Bharal</creatorcontrib><creatorcontrib>Jain, Seema</creatorcontrib><creatorcontrib>Agarwal, Nitin K.</creatorcontrib><creatorcontrib>Mediratta, Pramod K.</creatorcontrib><creatorcontrib>Sharma, Krishna K.</creatorcontrib><title>Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Epilepsy is a chronic neurological disorder affecting 1% population worldwide. A number of experimental studies have reported anticonvulsant, neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. The present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200
mg/kg, orally (p.o.) pentylenetetrazole-induced kindling in mice. Further two oxidative stress markers viz., malondialdehyde (MDA) and glutathione were estimated in brain tissues of rodents. Curcumin (50, 100 and 200
mg/kg, p.o.) dose dependently suppressed the progression of kindling in mice. In addition, the increased levels of MDA and glutathione were also reduced by curcumin in kindled animals. These results suggest that curcumin appears to possess protective activity against kindling in mice.</description><subject>Animals</subject><subject>Anticonvulsant</subject><subject>Anticonvulsants - pharmacology</subject><subject>Care and treatment</subject><subject>Curcuma</subject><subject>Curcumin</subject><subject>Curcumin - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Female</subject><subject>Glutathione - metabolism</subject><subject>Health aspects</subject><subject>Kindling</subject><subject>Kindling, Neurologic - drug effects</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Protective Agents - pharmacology</subject><subject>Turmeric</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoso7rj6D0QLXnjVek7a9ONGWBa_YMULXRBvQiY5GTO2yWzSLo6_3pTuXgiDJJCQPO_Jx5NlzxFKBGze7MvDz-NIumSwLGEJ0D7INthgV0DPvz_MNtDXddEiVmfZkxj3AFj3LTzOzhgyxJ5Xm-zHZ6_nQU7Wu9yb_EBuOg7kaKIpyD9-oMI6PSvS-a80Gazb5dLp3P-2OoVuKY9ToBjz7TFXc1DzaF2e-mgVPc0eGTlEenY3nmfX7999u_xYXH358Ony4qpQdQ9ToTrDQVZ1A6g57xrZm4pRgxw0xy3vEA3TpKk2SrEtI8YNkCHd9omu0FTn2eu17iH4m5niJEYbFQ2DdOTnKLoWAWreQCJfreRODiSsMz49Ui20uGANrzpsgSWqOEHt0qcEOXhHxqblf_jyBJ-apvQNJwP1GlDBxxjIiEOwowxHgSAWt2IvVrdicSsQRXKbYi_u3jlvl7370L3MBLxcASO9kLtgo7j-mio0SXzbsH45-e1KUPJxaymIqCy5pNcGUpPQ3v7_Dn8B_aG_mA</recordid><startdate>20110615</startdate><enddate>20110615</enddate><creator>Agarwal, Nidhi Bharal</creator><creator>Jain, Seema</creator><creator>Agarwal, Nitin K.</creator><creator>Mediratta, Pramod K.</creator><creator>Sharma, Krishna K.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110615</creationdate><title>Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice</title><author>Agarwal, Nidhi Bharal ; Jain, Seema ; Agarwal, Nitin K. ; Mediratta, Pramod K. ; Sharma, Krishna K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-c8f50a34601d5586a9f32e6150d51b5811f2dede4fcc2b2e25f0efed7955831f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Anticonvulsant</topic><topic>Anticonvulsants - pharmacology</topic><topic>Care and treatment</topic><topic>Curcuma</topic><topic>Curcumin</topic><topic>Curcumin - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Female</topic><topic>Glutathione - metabolism</topic><topic>Health aspects</topic><topic>Kindling</topic><topic>Kindling, Neurologic - drug effects</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Protective Agents - pharmacology</topic><topic>Turmeric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agarwal, Nidhi Bharal</creatorcontrib><creatorcontrib>Jain, Seema</creatorcontrib><creatorcontrib>Agarwal, Nitin K.</creatorcontrib><creatorcontrib>Mediratta, Pramod K.</creatorcontrib><creatorcontrib>Sharma, Krishna K.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agarwal, Nidhi Bharal</au><au>Jain, Seema</au><au>Agarwal, Nitin K.</au><au>Mediratta, Pramod K.</au><au>Sharma, Krishna K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2011-06-15</date><risdate>2011</risdate><volume>18</volume><issue>8</issue><spage>756</spage><epage>759</epage><pages>756-759</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Epilepsy is a chronic neurological disorder affecting 1% population worldwide. 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mg/kg, orally (p.o.) pentylenetetrazole-induced kindling in mice. Further two oxidative stress markers viz., malondialdehyde (MDA) and glutathione were estimated in brain tissues of rodents. Curcumin (50, 100 and 200
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| subjects | Animals Anticonvulsant Anticonvulsants - pharmacology Care and treatment Curcuma Curcumin Curcumin - pharmacology Disease Models, Animal Epilepsy Epilepsy - drug therapy Female Glutathione - metabolism Health aspects Kindling Kindling, Neurologic - drug effects Male Malondialdehyde - metabolism Mice Mice, Inbred Strains Oxidative stress Oxidative Stress - drug effects Phytotherapy Plant Extracts - pharmacology Protective Agents - pharmacology Turmeric |
| title | Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice |
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