Multi-responsive nanogels containing motifs of ortho ester, oligo(ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs

A family of multi-responsive nanogels with different compositions and crosslinking degrees have been prepared by the miniemulsion copolymerization of monomethyl oligo(ethylene glycol) acrylate (OEGA) and an ortho ester-containing acrylic monomer, 2-(5,5-dimethyl-1,3-dioxan-2-yloxy) ethyl acrylate (D...

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Veröffentlicht in:	Journal of controlled release 2011-05, Vol.152 (1), p.57-66
Hauptverfasser:	Qiao, Zeng-Ying, Zhang, Rui, Du, Fu-Sheng, Liang, De-Hai, Li, Zi-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-labile Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry atomic force microscopy Biological and medical sciences Controlled release crosslinking Disulfide bonds Disulfides - chemistry Dithiothreitol Dithiothreitol - pharmacology Doxorubicin Doxorubicin - administration & dosage Drug Carriers Drug delivery Drugs encapsulation Esters General pharmacology high performance liquid chromatography Hydrogen-Ion Concentration Hydrolysis Hydrophobic and Hydrophilic Interactions Hydrophobicity Light scattering Medical sciences Monomers Nanogel Oligo(ethylene glycol) Ortho ester Oxazines - administration & dosage Paclitaxel Paclitaxel - administration & dosage Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phase transition Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethyleneimine Polymerization polymers Reduction-sensitive Spectrometry spectroscopy Temperature Temperature effects Thermoresponsive Toxicity Transmission electron microscopy
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