β2 -Glycoprotein-I based peptide regulate endothelial-cells tissue-factor expression via negative regulation of pGSK3β expression and reduces experimental-antiphospholipid-syndrome

Abstract Antiphospholipid syndrome (APS) is characterized by thromboembolic phenomena and recurrent fetal loss associated with elevated circulating anti-phospholipid/beta2glycoprotein-I(β2GPI)-binding-antibodies(Abs). Individual APS patients harbor diverse clusters of circulating anti-β2GPI Abs, tar...

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Veröffentlicht in:	Journal of autoimmunity 2011-08, Vol.37 (1), p.8-17
Hauptverfasser:	Blank, Miri, Baraam, Liran, Eisenstein, Miriam, Fridkin, Mati, Dardik, Rima, Heldman, Yehudit, Katchalski-Katzir, Ephraim, Shoenfeld, Yehuda
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Antiphospholipid - immunology Antibodies, Antiphospholipid - metabolism Antiphospholipid Syndrome - enzymology Antiphospholipid Syndrome - physiopathology beta 2-Glycoprotein I - chemistry beta 2-Glycoprotein I - immunology beta 2-Glycoprotein I - pharmacology Biological and medical sciences Disease Models, Animal E-Selectin - metabolism Endothelial Cells - drug effects Endothelial Cells - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Female Fetal Death - immunology Fetal Death - prevention & control Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - immunology General aspects Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Humans Immunopathology Male Medical sciences Mice Mice, Inbred BALB C Peptides - chemical synthesis Peptides - pharmacology Phospholipids - immunology Phospholipids - metabolism Phosphorylation - drug effects Protein Binding - drug effects Protein Conformation RNA, Messenger - metabolism Thromboplastin - genetics Thromboplastin - metabolism
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