Epicardial application of an amiodarone-releasing hydrogel to suppress atrial tachyarrhythmias

Abstract Background Amiodarone is currently the most effective antiarrhythmic drug for sinus rhythm maintenance. However, due to serious extracardiac adverse effects, prophylactic amiodarone therapy is only appropriate for patients at high risk for postoperative atrial fibrillation (AF). We hypothes...

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Veröffentlicht in:	International journal of cardiology 2011-06, Vol.149 (3), p.341-346
Hauptverfasser:	Bolderman, Robert W, Hermans, J.J. Rob, Rademakers, Leonard M, de Jong, Monique M.J, Bruin, Peter, Dias, Aylvin A, van der Veen, Frederik H, Maessen, Jos G
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Amiodarone Amiodarone - analogs & derivatives Amiodarone - blood Amiodarone - pharmacology Animals Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacology Arrhythmia Atrium Biological and medical sciences Cardiac dysrhythmias Cardiac Pacing, Artificial Cardiology. Vascular system Cardiovascular Disease Models, Animal Drug Delivery Systems - methods Electrodes, Implanted Goats Heart Heart Atria - drug effects Hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology Local drug delivery Medical sciences Pericardium - drug effects Polyethylene Glycols Refractory Period, Electrophysiological - drug effects Tachycardia, Ectopic Atrial - drug therapy
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