The structural and biological properties of hydroxyapatite-modified titanate nanowire scaffolds
Abstract Hydroxyapatite-modified titanate nanowire scaffolds as alternative materials for tissue engineering have been developed via a titanate nanowire matrix assisted electrochemical deposition method. The macroporous titanate nanowire matrix on Ti metal was fabricated by a hydrothermal method, an...
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| Veröffentlicht in: | Biomaterials 2011-09, Vol.32 (25), p.5837-5846 |
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| creator | Zhao, Haixin Dong, Wenjun Zheng, Yingying Liu, Aiping Yao, Juming Li, Chaorong Tang, Weihua Chen, Benyong Wang, Ge Shi, Zhan |
| description | Abstract Hydroxyapatite-modified titanate nanowire scaffolds as alternative materials for tissue engineering have been developed via a titanate nanowire matrix assisted electrochemical deposition method. The macroporous titanate nanowire matrix on Ti metal was fabricated by a hydrothermal method, and then followed by an electrochemical synthesis of hydroxyapatite nanoparticles on titanate nanowire. The incorporation of titanate nanowire matrix with high oriented hydroxyapatite nanoparticles generates hierarchical scaffolds with highly osteogenic, structural integrity and excellent mechanical performance. As-prepared porous three dimensional interconnected hydroxyapatite-modified titanate nanowire scaffolds, mimicking the nature’s extracellular matrix, could provide a suitable microenvironment for tissue cell ingrowth and differentiation. The ceramic titanate nanowire core with HA nanoparticle sheath structure displays superhydrophilicity, which facilitates the cell attachment and proliferation, and induces the in vitro tissue-engineered bone. Human osteoblast-like MG63 cells were cultured on the hydroxyapatite-modified titanate nanowire scaffolds, and the results showed that the scaffolds highly promote the bioactivity, osteoconductivity and osteoblast differentiation. |
| doi_str_mv | 10.1016/j.biomaterials.2011.04.083 |
| format | Article |
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The macroporous titanate nanowire matrix on Ti metal was fabricated by a hydrothermal method, and then followed by an electrochemical synthesis of hydroxyapatite nanoparticles on titanate nanowire. The incorporation of titanate nanowire matrix with high oriented hydroxyapatite nanoparticles generates hierarchical scaffolds with highly osteogenic, structural integrity and excellent mechanical performance. As-prepared porous three dimensional interconnected hydroxyapatite-modified titanate nanowire scaffolds, mimicking the nature’s extracellular matrix, could provide a suitable microenvironment for tissue cell ingrowth and differentiation. The ceramic titanate nanowire core with HA nanoparticle sheath structure displays superhydrophilicity, which facilitates the cell attachment and proliferation, and induces the in vitro tissue-engineered bone. Human osteoblast-like MG63 cells were cultured on the hydroxyapatite-modified titanate nanowire scaffolds, and the results showed that the scaffolds highly promote the bioactivity, osteoconductivity and osteoblast differentiation.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2011.04.083</identifier><identifier>PMID: 21605896</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Biomaterial ; Cell Line, Tumor ; Dentistry ; Durapatite - chemistry ; Humans ; Hydroxyapatite ; Microscopy, Fluorescence ; Nanowires ; Scaffold ; Titanate nanowire ; Titanium - chemistry</subject><ispartof>Biomaterials, 2011-09, Vol.32 (25), p.5837-5846</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-72e4f4ba92fa61f8317aacf7aec5989bc525041145381aa511c7a01d9c4157723</citedby><cites>FETCH-LOGICAL-c500t-72e4f4ba92fa61f8317aacf7aec5989bc525041145381aa511c7a01d9c4157723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2011.04.083$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21605896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Haixin</creatorcontrib><creatorcontrib>Dong, Wenjun</creatorcontrib><creatorcontrib>Zheng, Yingying</creatorcontrib><creatorcontrib>Liu, Aiping</creatorcontrib><creatorcontrib>Yao, Juming</creatorcontrib><creatorcontrib>Li, Chaorong</creatorcontrib><creatorcontrib>Tang, Weihua</creatorcontrib><creatorcontrib>Chen, Benyong</creatorcontrib><creatorcontrib>Wang, Ge</creatorcontrib><creatorcontrib>Shi, Zhan</creatorcontrib><title>The structural and biological properties of hydroxyapatite-modified titanate nanowire scaffolds</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract Hydroxyapatite-modified titanate nanowire scaffolds as alternative materials for tissue engineering have been developed via a titanate nanowire matrix assisted electrochemical deposition method. The macroporous titanate nanowire matrix on Ti metal was fabricated by a hydrothermal method, and then followed by an electrochemical synthesis of hydroxyapatite nanoparticles on titanate nanowire. The incorporation of titanate nanowire matrix with high oriented hydroxyapatite nanoparticles generates hierarchical scaffolds with highly osteogenic, structural integrity and excellent mechanical performance. As-prepared porous three dimensional interconnected hydroxyapatite-modified titanate nanowire scaffolds, mimicking the nature’s extracellular matrix, could provide a suitable microenvironment for tissue cell ingrowth and differentiation. The ceramic titanate nanowire core with HA nanoparticle sheath structure displays superhydrophilicity, which facilitates the cell attachment and proliferation, and induces the in vitro tissue-engineered bone. Human osteoblast-like MG63 cells were cultured on the hydroxyapatite-modified titanate nanowire scaffolds, and the results showed that the scaffolds highly promote the bioactivity, osteoconductivity and osteoblast differentiation.</description><subject>Advanced Basic Science</subject><subject>Biomaterial</subject><subject>Cell Line, Tumor</subject><subject>Dentistry</subject><subject>Durapatite - chemistry</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Microscopy, Fluorescence</subject><subject>Nanowires</subject><subject>Scaffold</subject><subject>Titanate nanowire</subject><subject>Titanium - chemistry</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1v1DAQtRCIbgt_AUVcOCXMOHY-OCChAgWpEgfK2Zp1xtRLNl7shLL_HkdbEOLEafSk997MvCfEc4QKAZuXu2rrw55mjp7GVElArEBV0NUPxAa7tit1D_qh2AAqWfYNyjNxntIOMgYlH4sziQ3orm82wtzccpHmuNh5iTQWNA1Fdh_DV28zPMRw4Dh7TkVwxe1xiOHnkQ40-5nLfRi88zwUGdGU7ykmmsKdj9nRknNhHNIT8cjlI_np_bwQX96_u7n8UF5_uvp4-ea6tBpgLlvJyqkt9dJRg66rsSWyriW2uu_6rdVSg0JUuu6QSCPalgCH3irUbSvrC_Hi5Jsv_r5wms3eJ8vjSBOHJZmuRQDZK8jMVyemjSGlyM4cot9TPBoEs-ZrdubvfM2arwFlcr5Z_Ox-zbLd8_BH-jvQTHh7InB-9ofnaJL1PFkecix2NkPw_7fn9T82dvTTWsk3PnLahSVOqwZNkgbM57XptWjMX2rQff0LKsyppQ</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Zhao, Haixin</creator><creator>Dong, Wenjun</creator><creator>Zheng, Yingying</creator><creator>Liu, Aiping</creator><creator>Yao, Juming</creator><creator>Li, Chaorong</creator><creator>Tang, Weihua</creator><creator>Chen, Benyong</creator><creator>Wang, Ge</creator><creator>Shi, Zhan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>The structural and biological properties of hydroxyapatite-modified titanate nanowire scaffolds</title><author>Zhao, Haixin ; Dong, Wenjun ; Zheng, Yingying ; Liu, Aiping ; Yao, Juming ; Li, Chaorong ; Tang, Weihua ; Chen, Benyong ; Wang, Ge ; Shi, Zhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-72e4f4ba92fa61f8317aacf7aec5989bc525041145381aa511c7a01d9c4157723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Advanced Basic Science</topic><topic>Biomaterial</topic><topic>Cell Line, Tumor</topic><topic>Dentistry</topic><topic>Durapatite - chemistry</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Microscopy, Fluorescence</topic><topic>Nanowires</topic><topic>Scaffold</topic><topic>Titanate nanowire</topic><topic>Titanium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Haixin</creatorcontrib><creatorcontrib>Dong, Wenjun</creatorcontrib><creatorcontrib>Zheng, Yingying</creatorcontrib><creatorcontrib>Liu, Aiping</creatorcontrib><creatorcontrib>Yao, Juming</creatorcontrib><creatorcontrib>Li, Chaorong</creatorcontrib><creatorcontrib>Tang, Weihua</creatorcontrib><creatorcontrib>Chen, Benyong</creatorcontrib><creatorcontrib>Wang, Ge</creatorcontrib><creatorcontrib>Shi, Zhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Haixin</au><au>Dong, Wenjun</au><au>Zheng, Yingying</au><au>Liu, Aiping</au><au>Yao, Juming</au><au>Li, Chaorong</au><au>Tang, Weihua</au><au>Chen, Benyong</au><au>Wang, Ge</au><au>Shi, Zhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The structural and biological properties of hydroxyapatite-modified titanate nanowire scaffolds</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>32</volume><issue>25</issue><spage>5837</spage><epage>5846</epage><pages>5837-5846</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract Hydroxyapatite-modified titanate nanowire scaffolds as alternative materials for tissue engineering have been developed via a titanate nanowire matrix assisted electrochemical deposition method. The macroporous titanate nanowire matrix on Ti metal was fabricated by a hydrothermal method, and then followed by an electrochemical synthesis of hydroxyapatite nanoparticles on titanate nanowire. The incorporation of titanate nanowire matrix with high oriented hydroxyapatite nanoparticles generates hierarchical scaffolds with highly osteogenic, structural integrity and excellent mechanical performance. As-prepared porous three dimensional interconnected hydroxyapatite-modified titanate nanowire scaffolds, mimicking the nature’s extracellular matrix, could provide a suitable microenvironment for tissue cell ingrowth and differentiation. The ceramic titanate nanowire core with HA nanoparticle sheath structure displays superhydrophilicity, which facilitates the cell attachment and proliferation, and induces the in vitro tissue-engineered bone. Human osteoblast-like MG63 cells were cultured on the hydroxyapatite-modified titanate nanowire scaffolds, and the results showed that the scaffolds highly promote the bioactivity, osteoconductivity and osteoblast differentiation.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>21605896</pmid><doi>10.1016/j.biomaterials.2011.04.083</doi><tpages>10</tpages></addata></record> |
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| subjects | Advanced Basic Science Biomaterial Cell Line, Tumor Dentistry Durapatite - chemistry Humans Hydroxyapatite Microscopy, Fluorescence Nanowires Scaffold Titanate nanowire Titanium - chemistry |
| title | The structural and biological properties of hydroxyapatite-modified titanate nanowire scaffolds |
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