High Levels of Mannose-Binding Lectin Are Associated With Poor Outcomes After Lung Transplantation

Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of complement activation. Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk...

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Veröffentlicht in:	Transplantation 2011-05, Vol.91 (9), p.1044-1049
Hauptverfasser:	CARROLL, Katherine E, DEAN, Melinda M, HEATLEY, Susan L, MEEHAN, Aislin C, MIFSUD, Nicole A, KOTSIMBOS, Tom C, SNELL, Greg I, WESTALL, Glen P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alternative pathway Alveoli Biological and medical sciences bronchiolitis obliterans Bronchiolitis Obliterans - etiology Bronchoalveolar Lavage Fluid - chemistry Bronchus Cohort Studies Complement activation Donors Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genotype Genotypes Genotyping Graft rejection Graft Rejection - etiology Humans Immune system Infection Intensive care units Longitudinal Studies Lung Transplantation - adverse effects Lung Transplantation - physiology Male Mannose-binding lectin Mannose-Binding Lectin - blood Mannose-Binding Lectin - genetics Mannose-Binding Lectin - metabolism Medical sciences Middle Aged Mortality Mutation Peripheral blood mononuclear cells Pneumonia - etiology Retrospective Studies Serum levels Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors Tissue, organ and graft immunology Treatment Outcome Young Adult
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