High Levels of Mannose-Binding Lectin Are Associated With Poor Outcomes After Lung Transplantation
Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of complement activation. Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk...
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| Veröffentlicht in: | Transplantation 2011-05, Vol.91 (9), p.1044-1049 |
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| container_title | Transplantation |
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| creator | CARROLL, Katherine E DEAN, Melinda M HEATLEY, Susan L MEEHAN, Aislin C MIFSUD, Nicole A KOTSIMBOS, Tom C SNELL, Greg I WESTALL, Glen P |
| description | Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of complement activation. Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk in solid-organ transplant recipients.
We performed a retrospective study of MBL2 genotype and plasma and bronchoalveolar lavage (BAL) MBL levels in 37 lung transplant recipients (LTR). Plasma MBL levels were measured pretransplant and both plasma and BAL MBL levels were measured at 3, 6, and 12 months after lung transplantation. MBL2 genotyping was performed on recipient and donor peripheral blood mononuclear cells. Clinical variables analyzed included primary graft dysfunction, intensive care unit stay, acute allograft rejection, infection, bronchiolitis obliterans syndrome (BOS), and mortality.
Plasma MBL levels posttransplant were predicted by recipient, and not donor MBL2 genotype. Compared with pretransplant levels, plasma MBL was significantly increased at 3, 6, and 12 months posttransplant (P |
| doi_str_mv | 10.1097/TP.0b013e318212c7d6 |
| format | Article |
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We performed a retrospective study of MBL2 genotype and plasma and bronchoalveolar lavage (BAL) MBL levels in 37 lung transplant recipients (LTR). Plasma MBL levels were measured pretransplant and both plasma and BAL MBL levels were measured at 3, 6, and 12 months after lung transplantation. MBL2 genotyping was performed on recipient and donor peripheral blood mononuclear cells. Clinical variables analyzed included primary graft dysfunction, intensive care unit stay, acute allograft rejection, infection, bronchiolitis obliterans syndrome (BOS), and mortality.
Plasma MBL levels posttransplant were predicted by recipient, and not donor MBL2 genotype. Compared with pretransplant levels, plasma MBL was significantly increased at 3, 6, and 12 months posttransplant (P<0.05). LTR who developed BOS or died during the study period had higher plasma MBL levels at 6 and 12 months posttransplant (P ≤ 0.05) compared with LTR with stable graft function. MBL was not routinely detected in the lung allograft; however if present in the BAL at 3 and 6 months posttransplant, it was associated with the later development of BOS (P<0.05).
Plasma MBL levels increase after lung transplantation and persistently increased MBL levels are associated with poor long-term outcomes.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/TP.0b013e318212c7d6</identifier><identifier>PMID: 21394075</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Aged ; Alternative pathway ; Alveoli ; Biological and medical sciences ; bronchiolitis obliterans ; Bronchiolitis Obliterans - etiology ; Bronchoalveolar Lavage Fluid - chemistry ; Bronchus ; Cohort Studies ; Complement activation ; Donors ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genotype ; Genotypes ; Genotyping ; Graft rejection ; Graft Rejection - etiology ; Humans ; Immune system ; Infection ; Intensive care units ; Longitudinal Studies ; Lung Transplantation - adverse effects ; Lung Transplantation - physiology ; Male ; Mannose-binding lectin ; Mannose-Binding Lectin - blood ; Mannose-Binding Lectin - genetics ; Mannose-Binding Lectin - metabolism ; Medical sciences ; Middle Aged ; Mortality ; Mutation ; Peripheral blood mononuclear cells ; Pneumonia - etiology ; Retrospective Studies ; Serum levels ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue Donors ; Tissue, organ and graft immunology ; Treatment Outcome ; Young Adult</subject><ispartof>Transplantation, 2011-05, Vol.91 (9), p.1044-1049</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-88ad7f3f06b9f53c543afcf1cbfb2229491c10cd9e7e5daa393ec259c73814453</citedby><cites>FETCH-LOGICAL-c412t-88ad7f3f06b9f53c543afcf1cbfb2229491c10cd9e7e5daa393ec259c73814453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24158344$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21394075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CARROLL, Katherine E</creatorcontrib><creatorcontrib>DEAN, Melinda M</creatorcontrib><creatorcontrib>HEATLEY, Susan L</creatorcontrib><creatorcontrib>MEEHAN, Aislin C</creatorcontrib><creatorcontrib>MIFSUD, Nicole A</creatorcontrib><creatorcontrib>KOTSIMBOS, Tom C</creatorcontrib><creatorcontrib>SNELL, Greg I</creatorcontrib><creatorcontrib>WESTALL, Glen P</creatorcontrib><title>High Levels of Mannose-Binding Lectin Are Associated With Poor Outcomes After Lung Transplantation</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of complement activation. Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk in solid-organ transplant recipients.
We performed a retrospective study of MBL2 genotype and plasma and bronchoalveolar lavage (BAL) MBL levels in 37 lung transplant recipients (LTR). Plasma MBL levels were measured pretransplant and both plasma and BAL MBL levels were measured at 3, 6, and 12 months after lung transplantation. MBL2 genotyping was performed on recipient and donor peripheral blood mononuclear cells. Clinical variables analyzed included primary graft dysfunction, intensive care unit stay, acute allograft rejection, infection, bronchiolitis obliterans syndrome (BOS), and mortality.
Plasma MBL levels posttransplant were predicted by recipient, and not donor MBL2 genotype. Compared with pretransplant levels, plasma MBL was significantly increased at 3, 6, and 12 months posttransplant (P<0.05). LTR who developed BOS or died during the study period had higher plasma MBL levels at 6 and 12 months posttransplant (P ≤ 0.05) compared with LTR with stable graft function. MBL was not routinely detected in the lung allograft; however if present in the BAL at 3 and 6 months posttransplant, it was associated with the later development of BOS (P<0.05).
Plasma MBL levels increase after lung transplantation and persistently increased MBL levels are associated with poor long-term outcomes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alternative pathway</subject><subject>Alveoli</subject><subject>Biological and medical sciences</subject><subject>bronchiolitis obliterans</subject><subject>Bronchiolitis Obliterans - etiology</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchus</subject><subject>Cohort Studies</subject><subject>Complement activation</subject><subject>Donors</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>Graft rejection</subject><subject>Graft Rejection - etiology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infection</subject><subject>Intensive care units</subject><subject>Longitudinal Studies</subject><subject>Lung Transplantation - adverse effects</subject><subject>Lung Transplantation - physiology</subject><subject>Male</subject><subject>Mannose-binding lectin</subject><subject>Mannose-Binding Lectin - blood</subject><subject>Mannose-Binding Lectin - genetics</subject><subject>Mannose-Binding Lectin - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Peripheral blood mononuclear cells</subject><subject>Pneumonia - etiology</subject><subject>Retrospective Studies</subject><subject>Serum levels</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90cGOFCEQBmBiNO7s6hOYGC5GL70CBQMcx43umozZOYzx2KHpYhfT04xAm_j2YnbUxIMnDvX9VaSKkBecXXJm9dv97pINjAMCN4ILr8f1I7LiCmS3ZoY9JivGJO84gD4j56V8ZYwp0PopORMcrGRarchwE-_u6Ra_41RoCvSTm-dUsHsX5zHOd63ia5zpJiPdlJJ8dBVH-iXWe7pLKdPbpfp0wEI3oWKm26Vl9tnN5Ti5uboa0_yMPAluKvj89F6Qzx_e769uuu3t9cerzbbzkovaGeNGHSCw9WCDAq8kuOAD90MYhBBWWu4586NFjWp0DiygF8p6DYZLqeCCvH7oe8zp24Kl9odYPE7tI5iW0hvNGRNasCbf_Fc2Z4xUUthG4YH6nErJGPpjjgeXfzTU_zpDv9_1_56hpV6eBizDAcc_md97b-DVCbji3RTaxnwsf53kyoCU8BMg7JCY</recordid><startdate>20110515</startdate><enddate>20110515</enddate><creator>CARROLL, Katherine E</creator><creator>DEAN, Melinda M</creator><creator>HEATLEY, Susan L</creator><creator>MEEHAN, Aislin C</creator><creator>MIFSUD, Nicole A</creator><creator>KOTSIMBOS, Tom C</creator><creator>SNELL, Greg I</creator><creator>WESTALL, Glen P</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20110515</creationdate><title>High Levels of Mannose-Binding Lectin Are Associated With Poor Outcomes After Lung Transplantation</title><author>CARROLL, Katherine E ; DEAN, Melinda M ; HEATLEY, Susan L ; MEEHAN, Aislin C ; MIFSUD, Nicole A ; KOTSIMBOS, Tom C ; SNELL, Greg I ; WESTALL, Glen P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-88ad7f3f06b9f53c543afcf1cbfb2229491c10cd9e7e5daa393ec259c73814453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alternative pathway</topic><topic>Alveoli</topic><topic>Biological and medical sciences</topic><topic>bronchiolitis obliterans</topic><topic>Bronchiolitis Obliterans - etiology</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Bronchus</topic><topic>Cohort Studies</topic><topic>Complement activation</topic><topic>Donors</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Genotyping</topic><topic>Graft rejection</topic><topic>Graft Rejection - etiology</topic><topic>Humans</topic><topic>Immune system</topic><topic>Infection</topic><topic>Intensive care units</topic><topic>Longitudinal Studies</topic><topic>Lung Transplantation - adverse effects</topic><topic>Lung Transplantation - physiology</topic><topic>Male</topic><topic>Mannose-binding lectin</topic><topic>Mannose-Binding Lectin - blood</topic><topic>Mannose-Binding Lectin - genetics</topic><topic>Mannose-Binding Lectin - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mutation</topic><topic>Peripheral blood mononuclear cells</topic><topic>Pneumonia - etiology</topic><topic>Retrospective Studies</topic><topic>Serum levels</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue Donors</topic><topic>Tissue, organ and graft immunology</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARROLL, Katherine E</creatorcontrib><creatorcontrib>DEAN, Melinda M</creatorcontrib><creatorcontrib>HEATLEY, Susan L</creatorcontrib><creatorcontrib>MEEHAN, Aislin C</creatorcontrib><creatorcontrib>MIFSUD, Nicole A</creatorcontrib><creatorcontrib>KOTSIMBOS, Tom C</creatorcontrib><creatorcontrib>SNELL, Greg I</creatorcontrib><creatorcontrib>WESTALL, Glen P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CARROLL, Katherine E</au><au>DEAN, Melinda M</au><au>HEATLEY, Susan L</au><au>MEEHAN, Aislin C</au><au>MIFSUD, Nicole A</au><au>KOTSIMBOS, Tom C</au><au>SNELL, Greg I</au><au>WESTALL, Glen P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Levels of Mannose-Binding Lectin Are Associated With Poor Outcomes After Lung Transplantation</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2011-05-15</date><risdate>2011</risdate><volume>91</volume><issue>9</issue><spage>1044</spage><epage>1049</epage><pages>1044-1049</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of complement activation. Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk in solid-organ transplant recipients.
We performed a retrospective study of MBL2 genotype and plasma and bronchoalveolar lavage (BAL) MBL levels in 37 lung transplant recipients (LTR). Plasma MBL levels were measured pretransplant and both plasma and BAL MBL levels were measured at 3, 6, and 12 months after lung transplantation. MBL2 genotyping was performed on recipient and donor peripheral blood mononuclear cells. Clinical variables analyzed included primary graft dysfunction, intensive care unit stay, acute allograft rejection, infection, bronchiolitis obliterans syndrome (BOS), and mortality.
Plasma MBL levels posttransplant were predicted by recipient, and not donor MBL2 genotype. Compared with pretransplant levels, plasma MBL was significantly increased at 3, 6, and 12 months posttransplant (P<0.05). LTR who developed BOS or died during the study period had higher plasma MBL levels at 6 and 12 months posttransplant (P ≤ 0.05) compared with LTR with stable graft function. MBL was not routinely detected in the lung allograft; however if present in the BAL at 3 and 6 months posttransplant, it was associated with the later development of BOS (P<0.05).
Plasma MBL levels increase after lung transplantation and persistently increased MBL levels are associated with poor long-term outcomes.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21394075</pmid><doi>10.1097/TP.0b013e318212c7d6</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Alternative pathway Alveoli Biological and medical sciences bronchiolitis obliterans Bronchiolitis Obliterans - etiology Bronchoalveolar Lavage Fluid - chemistry Bronchus Cohort Studies Complement activation Donors Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genotype Genotypes Genotyping Graft rejection Graft Rejection - etiology Humans Immune system Infection Intensive care units Longitudinal Studies Lung Transplantation - adverse effects Lung Transplantation - physiology Male Mannose-binding lectin Mannose-Binding Lectin - blood Mannose-Binding Lectin - genetics Mannose-Binding Lectin - metabolism Medical sciences Middle Aged Mortality Mutation Peripheral blood mononuclear cells Pneumonia - etiology Retrospective Studies Serum levels Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors Tissue, organ and graft immunology Treatment Outcome Young Adult |
| title | High Levels of Mannose-Binding Lectin Are Associated With Poor Outcomes After Lung Transplantation |
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