Functionalized linear poly(amidoamine)s are efficient vectors for intracellular protein delivery

An effective intracellular protein delivery system was developed based on functionalized linear poly(amidoamine)s (PAAs) that form self-assembled cationic nanocomplexes with oppositely charged proteins. Three differently functionalized PAAs were synthesized, two of these having repetitive disulfide...

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Veröffentlicht in:	Journal of controlled release 2011-05, Vol.152 (1), p.90-98
Hauptverfasser:	Coué, Grégory, Engbersen, Johan F.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta -Galactosidase beta-Galactosidase - administration & dosage beta-Galactosidase - chemistry beta-Galactosidase - pharmacokinetics beta-Galactosidase - pharmacology Biological and medical sciences Bioreducible polymers Controlled release Cytotoxicity Disulfide bonds Disulfide reduction Drug Delivery Systems Enzymes General pharmacology Histamine Hydrogen-Ion Concentration Intracellular protein delivery Medical sciences Nanoparticles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments piperazine Poly(amidoamine) Polyamines - administration & dosage Polyamines - chemistry Polyelectrolyte complex proteins Proteins - administration & dosage Self-assembly
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