Reduction of cold ischemia–reperfusion injury by graft-expressing clusterin in heart transplantation

Background Cold ischemia–reperfusion injury (IRI) is a major factor for early graft dysfunction and is associated with rejection episodes in heart transplantation. Clusterin (CLU) is a cytoprotective protein with chaperone activity. This study was designed to examine the impact of donor-expressing C...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2011-07, Vol.30 (7), p.819-826
Hauptverfasser:	Li, Shuyuan, MD, Guan, Qiunong, MPhil, Chen, Zhishui, MD, PhD, Gleave, Martin E., MD, PhD, Nguan, Christopher Y.C., MD, Du, Caigan, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Cell Death clusterin Clusterin - metabolism cold ischemia Cold Ischemia - adverse effects cold preservation Disease Models, Animal Graft Rejection Heart Transplantation ischemia–reperfusion injury Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocytes, Cardiac - metabolism Reperfusion Injury - prevention & control Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart
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