siRNA nanocarriers based on methacrylic acid copolymers

Poly(ethylene glycol)- b-poly(propyl methacrylate- co-methacrylic acid) (PEG- b-P(PrMA- co-MAA) can be complexed with poly(amido amine) (PAMAM) dendrimers and nucleic acids to form pH-responsive nanosized core-shell type polyion complex micelles (PICMs). These PICMs have the ability to lose their sh...

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Veröffentlicht in:	Journal of controlled release 2011-05, Vol.152 (1), p.159-167
Hauptverfasser:	Felber, Arnaud E., Castagner, Bastien, Elsabahy, Mahmoud, Deleavey, Glen F., Damha, Masad J., Leroux, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	amines Antibodies Bcl-2 Bcl-2 protein Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects composite polymers Controlled release Copolymers Data processing Endocytosis Esters ethylene glycol Flow cytometry Gene Transfer Techniques General pharmacology Humans Male Medical sciences messenger RNA Methacrylic acid Methacrylic acid copolymers Micelles mRNA nanocarriers Nanoparticles - chemistry neoplasm cells nucleic acids oncogene proteins pH effects pH-sensitivity Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - chemistry Polyion complex micelles Polymethacrylic Acids - chemical synthesis Polymethacrylic Acids - chemistry Prostate cancer prostatic neoplasms RNA, Small Interfering - chemistry Shells siRNA small interfering RNA transferrin Transferrin receptors
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