Characterization of a panel of monoclonal antibodies toward mouse PAI-1 that exert a significant profibrinolytic effect in vivo

Abstract Introduction PAI-1 is the main physiological inhibitor of t-PA and u-PA. Elevated PAI-1 levels have been implicated in the pathogenesis of several thrombotic and non-thrombotic diseases. The effect of PAI-1 inhibition can be studied in mouse models, when appropriate immunological tools are...

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Veröffentlicht in:	Thrombosis research 2011-07, Vol.128 (1), p.68-76
Hauptverfasser:	Van De Craen, Britt, Scroyen, Ilse, Abdelnabi, Rana, Brouwers, Els, Lijnen, H. Roger, Declerck, Paul J, Gils, Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Cross Reactions Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Epitope Mapping Fibrinolysis Glycosylation Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Inhibition Medical sciences Mice Models, Animal Monoclonal antibodies Mouse PAI-1 Pharmacology. Drug treatments Plasminogen Activator Inhibitor 1 - chemistry Plasminogen Activator Inhibitor 1 - immunology Plasminogen Activator Inhibitor 1 - metabolism Thromboembolism - drug therapy Thromboembolism - immunology Thromboembolism - metabolism Vasodilator agents. Cerebral vasodilators Vitronectin - pharmacology
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